Catalog No.
YHF14601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala24-Ala365
Predicted molecular weight
39.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55899
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway., PMID:40505347
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway., PMID:40124052
A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity., PMID:40020261
Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by Enteroviruses to Infect Cells., PMID:39940693
Population Pharmacokinetic Model of Intravenous Immunoglobulin in Patients Treated for Various Immune System Disorders., PMID:39366801
Neonatal Fc receptor is a functional receptor for classical human astrovirus., PMID:39266307
Rhesus Macaques: VNTR Polymorphism of the FCGRT Gene., PMID:39134810
Identifying the immunoglobulin G transporter in equine tissues: A look at the neonatal Fc receptor., PMID:38879095
Characterizing Common and Rare Variations in Nontraditional Glycemic Biomarkers Using Multivariate Approaches on Multiancestry ARIC Study., PMID:38869630
Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy., PMID:38205888
Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia., PMID:38145833
FcRn Expression in Endometrial Cancer and Its Association with Clinicopathologic Features., PMID:38132243
The endosomal system of primary human vascular endothelial cells and albumin-FcRn trafficking., PMID:37565427
Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels., PMID:37128921
Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas., PMID:37077920
Allele mining in gene encoding fc fragment of IgG receptor, transporter, alpha (FCGRT) and association of nucleotide variants with passive transfer of immunity in neonatal buffalo calves., PMID:36757548
Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant HLADQA1*05G>A Genotype., PMID:36112504
Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18., PMID:35862785
Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia., PMID:35841099
Next-Generation Sequencing analysis discloses genes implicated in equine endometrosis that may lead to tumorigenesis., PMID:35760027
Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids., PMID:35579465
Altered gene expression and PTSD symptom dimensions in World Trade Center responders., PMID:35177824
Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis)., PMID:35152368
An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript., PMID:34753797
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21)., PMID:34040082
Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33460483
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice., PMID:33025844
Megalin-mediated albumin endocytosis in cultured murine mesangial cells., PMID:32736701
The neonatal Fc receptor in cancer FcRn in cancer., PMID:32368865
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium., PMID:31209240
Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B., PMID:31104841
Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment., PMID:30323819
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex., PMID:29306331
Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181., PMID:29302759
Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species., PMID:29270774
Brain antibodies in the cortex and blood of people with schizophrenia and controls., PMID:28786974
Functional polymorphisms in rhesus macaque FCGRT and β2-m., PMID:28785825
Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer., PMID:28450240
Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs., PMID:27900359
Bevacizumab Pharmacokinetics Influence Overall and Progression-Free Survival in Metastatic Colorectal Cancer Patients., PMID:27312193
Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103+ Dendritic Cells Confers Transient Susceptibility to Tuberculosis., PMID:27481246
Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis., PMID:27384673
Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT)., PMID:26252948
DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs., PMID:26038943
Claudin-4 undergoes age-dependent change in cellular localization on pig jejunal villous epithelial cells, independent of bacterial colonization., PMID:25948883
Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration., PMID:25867392
FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors., PMID:25823782
Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs., PMID:25654695
Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques., PMID:24806819
For research use only. Not for human or drug use.
