Catalog No.
YHF11401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn503-Val885
Predicted molecular weight
44.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55265
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Double-stranded RNA-specific adenosine deaminase, G1P1, IFI-4, ADAR, K88DSRBP, DRADA, ADAR1, IFI4, Interferon-inducible protein 4, p136, 136 kDa double-stranded RNA-binding protein, DSRAD
Treatment of human cells with the anti-cancer drug cisplatin results in the caspase-dependent release of adduct-containing cell-free DNA., PMID:40513340
Novel lncRNA UGGT1-AS1 Regulates UGGT1 Expression in Breast Cancer Cell Line., PMID:40507918
An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing., PMID:40419487
High-speed atomic force microscopy and 3D modeling reveal the structural dynamics of ADAR1 complexes., PMID:40419486
Emerging clinical applications of ADAR based RNA editing., PMID:40418634
RNA Editing-Mediated Correction of TP53 Nonsense Mutations via Lipid Nanoparticle-Delivered Circular ADAR-Recruiting RNAs., PMID:40397606
3'UTR RNA editing driven by ADAR1 modulates MDM2 expression in breast cancer cells., PMID:40381037
Paramutation-Like Behavior of Genic piRNA-Producing Loci in Drosophila virilis., PMID:40362480
GMP-like and MLP-like Subpopulations of Hematopoietic Stem and Progenitor Cells Harboring Mutated EZH2 and TP53 at Diagnosis Promote Acute Myeloid Leukemia Relapse: Data of Combined Molecular, Functional, and Genomic Single-Stem-Cell Analyses., PMID:40362463
Computer-Aided Discovery of Natural Compounds Targeting the ADAR2 dsRBD2-RNA Interface and Computational Modeling of Full-Length ADAR2 Protein Structure., PMID:40362314
A systematic evaluation of the therapeutic potential of endogenous-ADAR editors in cancer prevention and treatment., PMID:40330550
Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families., PMID:40302320
VIRMA promotes NSCLC progression by modifying ADAR m6A and increasing the activity of the TGF-β signaling pathway., PMID:40254620
ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer., PMID:40241135
Astrocytic RNA editing regulates the host immune response to alpha-synuclein., PMID:40215316
ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication., PMID:40198737
Harnessing RNA base editing for diverse applications in RNA biology and RNA therapeutics., PMID:40198443
Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA., PMID:40185749
A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC., PMID:40175891
Zα and Zβ Localize ADAR1 to Flipons That Modulate Innate Immunity, Alternative Splicing, and Nonsynonymous RNA Editing., PMID:40141064
Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma., PMID:40135601
C-Reactive Protein Is Associated with Severity in Hospitalized Children with Respiratory Syncytial Virus Bronchiolitis., PMID:40134169
Biochemical profiling and structural basis of ADAR1-mediated RNA editing., PMID:40101712
ADAR1-HNRNPL-Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease., PMID:40091520
Massive RNA Editing in Ascetosporean Mitochondria., PMID:40090735
A Simplified Guide RNA Synthesis Protocol for SNAP- and Halo-Tag-Based RNA Editing Tools., PMID:40076283
RNA editing applied to cystic fibrosis: RESTORE can target G542X CFTR mRNA and revert the nonsense mutation., PMID:40054708
Conformational reorganization and phase separation drive hyper-editing of ADR-2-ADBP-1 complex., PMID:40037706
Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR., PMID:39992915
Phylogenetic and structural analysis of Hydra ADAR., PMID:39986343
Evolutionary Origins and Adaptive Significance of A-to-I RNA Editing in Animals and Fungi., PMID:39981820
Unveiling the prognostic significance of RNA editing-related genes in colon cancer: evidence from bioinformatics and experiment., PMID:39940052
A molecular proximity sensor based on an engineered, dual-component guide RNA., PMID:39937081
The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency., PMID:39933696
Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in sorghum and sugarcane., PMID:39932987
[Aicardi-Goutieres syndrome type 6 associated with a compound heterozygous variant in ADAR: a first case report in the Russian population]., PMID:39930688
Targeting ADAR1 with a small molecule for the treatment of prostate cancer., PMID:39930013
Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration., PMID:39922978
Silencing LINC01547 induces hepatocellular carcinoma cell apoptosis and metastasis inhibition via the ADAR1/FAK and miR-146b-5p/RAC1 axes., PMID:39904859
Clinical Impact of Cellular Senescence and RNA Dysregulation in HCC Is Associated With MASLD and HCV-SVR., PMID:39890171
Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction., PMID:39885125
Editing specificity of ADAR isoforms., PMID:39870452
Aptazyme-directed A-to-I RNA editing., PMID:39870449
Restoration of G to A mutated transcripts using the MS2-ADAR1 system., PMID:39870447
CellREADR: An ADAR-based RNA sensor-actuator device., PMID:39870446
Structural analysis of human ADAR2-RNA complexes by X-ray crystallography., PMID:39870445
Mouse models for understanding physiological functions of ADARs., PMID:39870443
Leveraging Saccharomyces cerevisiae for ADAR research: From high-yield purification to high-throughput screening and therapeutic applications., PMID:39870441
ADAR Therapeutics as a New Tool for Personalized Medicine., PMID:39858624
For research use only. Not for human or drug use.
