Catalog No.
YHF11101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala194-Asn293
Predicted molecular weight
13.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55212
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apoptotic protease Mch-2, Caspase-6, CASP-6, MCH2, CASP6
Targeting Caspases 3/6 and Cathepsins L/B May Decrease Laminopathy-Induced Apoptosis in Alzheimer's Disease., PMID:39121120
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death., PMID:39032719
Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice., PMID:38040383
Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections., PMID:34740613
Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment., PMID:34625662
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits., PMID:33649324
Remodeling hydrogen bond interactions results in relaxed specificity of Caspase-3., PMID:33448281
Anticancer active trifluoromethylated fused triazinones are safe for early-life stages of zebrafish (Danio rerio) and reveal a proapoptotic action., PMID:33390035
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury., PMID:32999158
Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity through netrin-1 in postoperative pain after orthopedic surgery for tibial fracture in mice., PMID:32701657
Compromised IGF signaling causes caspase-6 activation in Huntington disease., PMID:32622701
Kopetdaghinanes, pro-apoptotic hemiacetialic cyclomyrsinanes from Euphorbia kopetdaghi., PMID:32464255
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense., PMID:32298652
De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance., PMID:31952546
Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis., PMID:31736475
A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest., PMID:31693684
Identification of Allosteric Inhibitors against Active Caspase-6., PMID:30940883
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis., PMID:30420425
Nitrite Protects Neurons Against Hypoxic Damage Through S-nitrosylation of Caspase-6., PMID:30417658
Cell type-dependent effects of ellagic acid on cellular metabolism., PMID:29990828
Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity., PMID:29535332
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6., PMID:29352267
Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal Degeneration., PMID:29229552
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity., PMID:29193273
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions., PMID:28864531
Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency., PMID:28726391
Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death., PMID:28659495
Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes., PMID:28585113
MicroRNA-195 prevents dendritic degeneration and neuron death in rats following chronic brain hypoperfusion., PMID:28569780
Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo., PMID:28508578
Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells., PMID:28322794
Caspase 3, 6, 8, and 9 Gene Expression in Peripheral Blood Leukocytes and Plasma Concentrations of IL-6 and TNF-α in Carriers of Different Polymorphic Marker -174G>C Genotypes of IL6 Gene Associated with the Risk of Nonalcoholic Steatohepatitis., PMID:28091912
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment., PMID:27931265
HER2-targeted recombinant protein immuno-caspase-6 effectively induces apoptosis in HER2-overexpressing GBM cells in vitro and in vivo., PMID:27633091
Identification of cleavage of NS5A of C-strain classical swine fever virus., PMID:27766426
Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31., PMID:27669734
The level of cytokines and expression of caspase genes in rheumatoid arthritis., PMID:27417728
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages., PMID:27325699
Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells., PMID:27216028
Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling., PMID:27129147
Alpha-1 Antitrypsin and Lung Cell Apoptosis., PMID:27115949
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD., PMID:26908611
Molecular mechanism of apoptosis induction by Gaillardin, a sesquiterpene lactone, in breast cancer cell lines : Gaillardin-induced apoptosis in breast cancer cell lines., PMID:26843455
Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line., PMID:26774143
Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7., PMID:26704356
Apoptotic and nonapoptotic function of caspase 7 in spermatogenesis., PMID:26643564
Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice., PMID:26193298
A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus., PMID:25516752
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent., PMID:25470254
[Antioxidative and antiapoptotic effects of the Attractin gene on Sertoli cells in mice]., PMID:25306804
For research use only. Not for human or drug use.
