Catalog No.
YHF10001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly28-Leu182
Predicted molecular weight
20.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55145
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET
Bridging systemic metabolic dysfunction and Alzheimer's disease: the liver interface., PMID:40437610
Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis., PMID:40371728
The impact of soft contact lenses on the corneal neuromediators and optical quality in high myopia., PMID:40350347
Secreted proteins in treating metabolic-dysfunction associated steatotic liver disease: from bench towards bedside., PMID:40243151
Associations of serum MANF with severity and prognosis in community-acquired pneumonia patients., PMID:40223005
Exosomal Manf originated from endothelium regulated osteoclast differentiation by down-regulating NF-κB signaling pathway., PMID:40197525
Biophysical Characterization and Preformulation Studies of Human Mesencephalic Astrocyte-Derived Neurotropic Factor., PMID:40168538
Oral pH- and inflammation-targeted delivery system with biodegradable multi-layer core-shell nanocapsules for the treatment of ulcerative colitis., PMID:40136045
Oral colon-targeted delivery of recombinant human MANF for alleviation of ulcerative colitis., PMID:40115964
Mesencephalic astrocyte-derived neurotrophic factor upregulates CHOP and ATF6 in the rat retina with retinitis pigmentosa., PMID:40113270
Myeloid-derived MANF ameliorates ethanol-induced liver injury by enhancing microRNA-223 expression., PMID:40111540
METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response., PMID:40103332
Paternal Obesity-Induced H3K27me3 Elevation Leads to MANF-Mediated Transgenerational Metabolic Dysfunction in Female Offspring., PMID:40041941
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma., PMID:39972058
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Restricts Inflammatory Progression through Limiting Macrophage Infiltration in DRG and Sciatic Nerve during Diabetic Peripheral Neuropathy., PMID:39970444
Mesencephalic astrocyte-derived neurotrophic factor (MANF): A novel therapeutic target for chemotherapy-induced peripheral neuropathy via regulation of integrated stress response and neuroinflammation., PMID:39909174
Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes., PMID:39865733
Involvement of PRDX6 in the protective role of MANF in acute lung injury in rats., PMID:39861940
Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies., PMID:39848413
Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway., PMID:39816847
Investigation of the mesencephalic astrocyte-derived neurotrophic factor-endoplasmic reticulum stress pathway in mood disorders., PMID:39803900
Mesencephalic astrocyte-derived neurotrophic factor inhibits neuroinflammation through autophagy-mediated α-synuclein degradation., PMID:39761611
MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression., PMID:39747250
Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammation., PMID:39666939
E3 Ubiquitin Ligase Ring Finger Protein 2 Alleviates Cerebral Ischemia-Reperfusion Injury by Stabilizing Mesencephalic Astrocyte-Derived Neurotrophic Factor Through Monoubiquitination., PMID:39614674
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Mitigates Neuroinflammation and Cognitive Impairment by Modulating Glial Activation in Sepsis-Associated Encephalopathy., PMID:39612058
Unlocking the promise of MANF in diseases: Mechanistic insights and therapeutic potentials., PMID:39549080
MANF inhibits NLRP3 inflammasome activation by competitively binding to DDX3X in paraquat-stimulated alveolar macrophages., PMID:39547060
Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF-HSF1-HSP70-1 pathway: An effective treatment for hepatocellular carcinoma., PMID:39525584
Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury., PMID:39462320
Molecular mechanisms of endoplasmic reticulum stress-mediated acute kidney injury in juvenile rats and the protective role of mesencephalic astrocyte-derived neurotrophic factor., PMID:39437337
Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease., PMID:39425207
The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans., PMID:39418305
Viral and nonviral approaches., PMID:39341664
MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling., PMID:39289348
Key subdomains of mesencephalic astrocyte-derived neurotrophic factor attenuate myocardial ischemia/reperfusion injury by JAK1/STAT1/NF-κB signaling pathway., PMID:39242993
Investigation of endoplasmic reticulum stress-regulated chaperones as biomarkers in idiopathic nonobstructive azoospermia., PMID:39237030
MANF facilitates breast cancer cell survival under glucose-starvation conditions via PRKN-mediated mitophagy regulation., PMID:39147386
Sex-specific effects of alcohol on neurobehavioral performance and endoplasmic reticulum stress: an analysis using neuron-specific MANF deficient mice., PMID:39130640
Machine learning and 4D-LFQ quantitative proteomic analysis explore the molecular mechanism of kidney stone formation., PMID:39114033
Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity., PMID:39075931
Stereocilia fusion pathology in the cochlear outer hair cells at the nanoscale level., PMID:39037943
Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha-synuclein levels in Lewy body disease., PMID:39036837
Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease., PMID:39019902
Identification of unique cell type responses in pancreatic islets to stress., PMID:38956087
Cerebrospinal fluid mesencephalic astrocyte-derived neurotrophic factor: A moderating effect on sleep time and cognitive function., PMID:38838432
Nitric oxide mediated kisspeptin regulation of steroidogenesis and gametogenesis in the catfish, Clarias batrachus., PMID:38829397
Identification of plasma protein markers of allergic disease risk: a mendelian randomization approach to proteomic analysis., PMID:38773393
Mesencephalic Astrocyte-derived Neurotrophic Factor Supports Hepatitis B Virus-induced Immunotolerance., PMID:38759839
Mesencephalic astrocyte-derived neurotrophic factor inhibits cervical cancer progression via regulating macrophage phenotype., PMID:38735002
For research use only. Not for human or drug use.
