Catalog No.
YHF00901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met56-Ser252
Predicted molecular weight
24.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P53805
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Down syndrome critical region protein 1, RCAN1, Calcipressin-1, DSC1, ADAPT78, CSP1, Adapt78, Regulator of calcineurin 1, MCIP1, DSCR1, Myocyte-enriched calcineurin-interacting protein 1
Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism., PMID:40495950
Utilizing Multi-omics analysis to elucidate the role of mitochondrial gene defects in Gastric cancer progression., PMID:40489463
Trametinib ameliorated Adriamycin-induced podocyte injury by inhibiting METTL3 modified m6A RCAN1 RNA methylation., PMID:40287046
Exploring the Interconnections Between Mitochondrial Dysfunction and Polycystic Ovary Syndrome: A Comprehensive Integrated Analysis., PMID:40259200
Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome., PMID:40042516
A nomogram for predicting overall survival in patients with gastric cancer based on tumor suppressor RCAN1.4 expression and clinical risk factors., PMID:39809174
RCAN1.4 regulates tumor cell engraftment and invasion in a thyroid cancer to lung metastasis-on-a-chip microphysiological system., PMID:39361514
Causal inference of the effect of plasma proteins on the incidence of oral cancer: two-sample Mendelian randomization., PMID:39245738
Biochemical analyses reveal new insights into RCAN1/Rcn1 inhibition of calcineurin., PMID:39241105
Identification of RCAN1's role in hepatocellular carcinoma using single-cell analysis., PMID:39192218
Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy., PMID:39053690
Rcn1, the fission yeast homolog of human DSCR1, regulates arsenite tolerance independently from calcineurin., PMID:38715219
Identification and functional analysis of lactic acid metabolism-related differentially expressed genes in hepatocellular carcinoma., PMID:38689649
The role of basic leucine zipper transcription factor E4BP4 in cancer: a review and update., PMID:38193973
Oxidative stress in Alzheimer's disease: current knowledge of signaling pathways and therapeutics., PMID:38165499
ATP5PO levels regulate enteric nervous system development in zebrafish, linking Hirschsprung disease to Down Syndrome., PMID:38128843
Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration., PMID:38066314
CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma., PMID:37918583
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles., PMID:37469132
Longitudinal modeling of human neuronal aging identifies RCAN1-TFEB pathway contributing to neurodegeneration of Huntington's disease., PMID:37214956
Identification of Key Functional Genes and LncRNAs Influencing Muscle Growth and Development in Leizhou Black Goats., PMID:37107639
Inverse Comorbidity between Down Syndrome and Solid Tumors: Insights from In Silico Analyses of Down Syndrome Critical Region Genes., PMID:37107558
MicroRNA-21-3p/Rcan1 signaling axis affects apoptosis of cardiomyocytes of sepsis rats., PMID:37098739
Hawthorn leaves flavonoids attenuate cardiac remodeling induced by simulated microgravity., PMID:37096968
The RCAN1.4 Metastasis Suppressor Is Hypermethylated at Intron 1 in Thyroid Cancer., PMID:37051697
Mice with double knockout of Egr-1 and RCAN1 exhibit reduced inflammation during Pseudomonas aeruginosa lung infection., PMID:36933529
Overexpression of RCAN1, a Gene on Human Chromosome 21, Alters Cell Redox and Mitochondrial Function in Enamel Cells., PMID:36429004
RCAN1 deficiency aggravates sepsis-induced cardiac remodeling and dysfunction by accelerating mitochondrial pathological fission., PMID:36305917
Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement., PMID:39086965
N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca2+ Pathway., PMID:36139036
Regulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through JNK/Mff signaling pathway., PMID:36071051
Assessment of expression of oxytocin-related lncRNAs in schizophrenia., PMID:35987251
Targeting upregulated RNA binding protein RCAN1.1: a promising strategy for neuroprotection in acute ischemic stroke., PMID:35900849
Upregulation of RCAN1.4 by HIF1α alleviates OGD-induced inflammatory response in astrocytes., PMID:35836352
Modulation of calcineurin signaling during development., PMID:35785416
RCAN1-mediated calcineurin inhibition as a target for cancer therapy., PMID:35717152
The PxIxIT motif of the RCAN3 inhibits angiogenesis and tumor progression in Triple Negative breast cancer in immunocompetent mice., PMID:35640493
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging., PMID:35610565
Microscale thermophoresis and fluorescence polarization assays of calcineurin-peptide interactions., PMID:35218735
APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons., PMID:35194165
Upregulation of RCAN1.4 in spinal dorsal horn is involved in inflammatory pain hypersensitivity., PMID:35189316
STAT3-regulated LncRNA LINC00160 mediates cell proliferation and cell metabolism of prostate cancer cells by repressing RCAN1 expression., PMID:35067783
Down Syndrome Candidate Region 1 Isoform 1L regulated tumor growth by targeting both angiogenesis and tumor cells., PMID:34958805
Common genetic signatures of Alzheimer's disease in Down Syndrome., PMID:33633844
GAP-43 ameliorates Podocyte injury by decreasing nuclear NFATc1 expression., PMID:34746448
RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2., PMID:34707090
Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q., PMID:34680233
MAP kinase/ERK kinase 1 (MEK1) phosphorylates regulator of calcineurin 1 (RCAN1) to regulate neuronal differentiation., PMID:34647615
Establishment of Down's syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT., PMID:34590290
Effect of umbilical cord blood stem cell transplantation on restenosis after endovascular interventional therapy for diabetic hindlimb vascular disease., PMID:34379650
For research use only. Not for human or drug use.
