Catalog No.
YHE96301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp109
Predicted molecular weight
14.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52926
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HMGA2, HMGIC, High mobility group protein HMGI-C, High mobility group AT-hook protein 2
Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation., PMID:40515848
HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis., PMID:40475780
Chromatin architecture protein HMGA2 promotes glioma malignancy via novel mechanism of IGFBP3 transcription inhibition., PMID:40450974
Investigating the Associations Between Hmga2 Overexpression, R-Loop Reduction, and Bone Loss in Aging Mice., PMID:40428778
HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity., PMID:40419509
EXPRESS: HMGA2-AS1 promotes the growth and cisplatin resistance in esophageal squamous cell carcinoma by enhancing HMGA2-dependent transcription of Snail2., PMID:40410936
[A Silver-Russell syndrome family with HMGA2 gene variant]., PMID:40393763
HMGA2 is an independent prognostic indicator and a potential therapeutic target for IDH-mutant astrocytoma., PMID:40379848
A systematic review of emerging RNA markers in thyroid fine needle aspiration cytology samples: advancements and challenges., PMID:40346322
Recurrent MDM2 Amplification in the Spectrum of HMGA2-Altered Pleomorphic Adenoma, Atypical Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma., PMID:40338436
circPOLA2 promotes proliferation, invasion, migration, and epithelial-mesenchymal transition in breast cancer via the miR-1224-5p/HMGA2 axis., PMID:40273496
The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation-Ubiquitylation Crosstalk of HMGA2., PMID:40265981
Uterine fibroids at single-cell resolution: unveiling cellular heterogeneity to improve understanding of pathogenesis and guide future therapies., PMID:40253076
UTERINE FIBROIDS., PMID:40214304
Investigating the role of HMGA2 plasma level as a diagnostic marker in bladder urothelial carcinoma patients., PMID:40204943
In silico screening system based on a transcription factors regulatory network only using transcriptomic data., PMID:40193394
Regulation of HSC development and function by Lin28b., PMID:40143971
Case Report and Literature Review: Overexpression of HMGA in Concomitant Plurihormonal Tumor and Papillary Thyroid Carcinoma., PMID:40114328
Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands., PMID:40033554
A novel mechanism in regulating drug sensitivity, growth, and apoptosis of bortezomib-resistant multiple myeloma cells: the USP4/KLF2/HMGA2 cascade., PMID:40022160
HMGA2 Overexpression in Papillary Thyroid Cancer Promotes Thyroid Cell Dedifferentiation and Invasion, and These Effects Are Counteracted by Suramin., PMID:40004107
Inhibition of ULK1 attenuates ferroptosis-mediated cardiac hypertrophy via HMGA2/METTL14/SLC7A11 axis in mice., PMID:39993699
Hexokinase 2 Suppression Alleviates the Catabolic Properties in Osteoarthritis via HMGA2 and Contributes to Pulsed Electromagnetic Field-mediated Cartilage Protection., PMID:39990654
Assessing the potential of high-mobility group AT-hook 2 immunohistochemical staining as a prognostic marker of metastatic recurrence in follicular thyroid cancer: a retrospective cohort study., PMID:39971318
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state., PMID:39930268
3' UTR-truncated HMGA2 promotes erythroblasts production from human embryonic stem cells., PMID:39912395
Inhibition of HMGA2 binding to AT-rich DNA by its negatively charged C-terminus., PMID:39873271
Balanced Translocation t(3;12) Disrupting HMGA2 and NAALADL2 Genes in Twins With Silver-Russell Syndrome and Intellectual Disability., PMID:39846526
The Transcriptomic and Gene Fusion Landscape of Pleomorphic Salivary Gland Adenomas., PMID:39812386
Dermal CIC-Rearranged Sarcoma With Neuroendocrine Differentiation Mimicking Merkel Cell Carcinoma., PMID:39737578
HMGA2 overexpression with specific chromosomal abnormalities predominate in CALR and ASXL1 mutated myelofibrosis., PMID:39715853
FOXF1 promotes ovarian cancer metastasis by facilitating HMGA2-mediated USP30-dependent S100A6 deubiquitination., PMID:39694080
HMGA2 Expression Predicts Subtype, Survival, and Treatment Outcome in Pancreatic Ductal Adenocarcinoma., PMID:39680021
The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis., PMID:39664573
Pleomorphic Adenoma With Disrupted Biphasic Ductal Structures Attributed to Lymphoid Infiltration: A Case Report., PMID:39618565
HMGA2 as a prognostic and immune biomarker in hepatocellular carcinoma: Comprehensive analysis of the HMG family and experiments validation., PMID:39591457
Rare Causes and Differential Diagnosis in Patients With Silver-Russell Syndrome., PMID:39586716
Regulation of the HMGA2-SNAI2/CXCR4 axis in atherosclerosis and retinal neovascularization: new therapeutic insights., PMID:39578310
Deciphering the toxicity of polyhexamethylene guanidine phosphate in lung carcinogenesis: Mutational profiles and molecular mechanisms., PMID:39577803
EIF4A3-induced circle RNA_ 0001860 promotes growth, invasion, and immune evasion of gastric cancer cells through the miR-618/HMGA2 axis., PMID:39556429
Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin-Positive Giant Cell Tumor., PMID:39552601
Exploring Testicular Descent: Recent Findings and Future Prospects in Canine Cryptorchidism., PMID:39504939
Myoid Hamartoma of the Breast With HMGA2 Rearrangement and Associated In-Situ and Invasive Carcinoma: Case Report and Review of Literature., PMID:39471995
HMGA2 regulates GPX4 expression and ferroptosis in prostate cancer cells., PMID:39447278
Distinguishing Genetic Alterations Versus (Epi)Mutations in Silver-Russell Syndrome and Focus on the IGF1R Gene., PMID:39412159
Distinct copy number signatures between residual benign and transformed areas of carcinoma ex pleomorphic adenoma., PMID:39384827
HMGA2-positive salivary gland neoplasms with prominent trabecular/canalicular morphology: a focus on carcinomas arising within this phenotype., PMID:39360582
Expanding the Molecular Spectrum of Carcinoma Ex Pleomorphic Adenoma: An Analysis of 84 Cases With a Novel HMGA2::LINC02389 Fusion., PMID:39324957
Insights into the molecular alterations of PLAG1 and HMGA2 associated with malignant phenotype acquisition in pleomorphic adenoma., PMID:39278426
For research use only. Not for human or drug use.
