Catalog No.
YHE94901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Trp619-Arg917
Predicted molecular weight
35.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52789
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HK II, Hexokinase type II, Hexokinase-2, Hexokinase-B, HK2, Muscle form hexokinase
HOTAIR Knockdown Increases the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib by Disrupting miR-145-5p/HK2 Axis-Mediated Mitochondrial Function and Glycolysis., PMID:40464518
Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy., PMID:40417885
SPARC Promotes Aerobic Glycolysis and 5-Fluorouracil Resistance in Colorectal Cancer Through the STAT3/HK2 Axis., PMID:40415238
Compromised adenosine-A2AR axis contributes to recurrent spontaneous abortion by promoting proinflammatory macrophage polarization., PMID:40373597
Glucose transporter 2‑transported glucosamine inhibits glycolysis in cancer cell lines through competition with glucose for hexokinase II., PMID:40314081
DPP8/9 processing of human AK2 unmasks an IAP binding motif., PMID:40312560
Hexokinase 2-driven aerobic glycolysis modulates YAP1 in placental trophoblast development., PMID:40286881
The relevance of resveratrol in ameliorating carotid atherosclerosis through glycolysis., PMID:40259219
Inhibiting Glycolysis and Disrupting the Mitochondrial HK2-VDAC1 Protein-Protein Interaction Using a Bifunctional Lonidamine-Conjugated Metal Probe for Combating Triple-Negative Breast Cancer., PMID:40251733
Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation., PMID:40250775
Paeonol inhibits the Glycolysis in oral squamous cell carcinoma though suppressing NAT10-mediated ac4C modification., PMID:40197308
Hexokinase2-engineered T cells display increased anti-tumor function., PMID:40181966
[High expression of hexokinase 2 promotes proliferation, migration and invasion of colorectal cancer cells by activating the JAK/STAT pathway and regulating tumor immune microenvironment]., PMID:40159969
An in- vitro measurement for the toxicity of peptides inhibit hexokinase II in breast cancer cell lines., PMID:40148397
CircRUNX1 enhances the Warburg effect and immune evasion in non-small cell lung cancer through the miR-145/HK2 pathway., PMID:40090573
Inflammatory stimuli and hypoxia on atherosclerotic plaque thrombogenicity: Linking macrophage tissue factor and glycolysis., PMID:40036261
Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation., PMID:40019223
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD., PMID:40014451
The Role of HK2 in Tumorigenesis and Development: Potential for Targeted Therapy with Natural Products., PMID:39991762
Glucose homeostasis controls N-acetyltransferase 10-mediated ac4C modification of HK2 to drive gastric tumorigenesis., PMID:39990211
Neurturin-induced activation of GFRA2-RET axis potentiates pancreatic cancer glycolysis via phosphorylated hexokinase 2., PMID:39988080
VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis., PMID:39880844
Antibiotic-derived approaches in cancer therapy: effectiveness of ikarugamycin in hexokinase-2 inhibition, tissue factor modulation, and metabolic regulation in breast cancer., PMID:39879102
Soy Isoflavone Genistein Enhances Tamoxifen Sensitivity in Breast Cancer via microRNA and Glucose Metabolism Modulation., PMID:39859445
SOX2 promotes the glycolysis process to accelerate cervical cancer progression by regulating the expression of HK2., PMID:39823909
Activation of mTOR/HK2 signaling mitigates effects of PYCR2 depletion in colorectal cells., PMID:39808866
SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway., PMID:39794543
Curcumin and Its Potential to Target the Glycolytic Behavior of Lactate-Acclimated Prostate Carcinoma Cells with Docetaxel., PMID:39770959
Dual-template epitope imprinted nanoparticles for anti-glycolytic tumor-targeted treatment., PMID:39755015
[Mechanism of WAVE1 regulation of lipopolysaccharide-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages]., PMID:39725399
Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis., PMID:39699276
USP22 Promotes Osteosarcoma Progression by Stabilising β-Catenin and Upregulating HK2 and Glycolysis., PMID:39661501
Rocaglamide reprograms glucose metabolism in erythroleukemic cells via c-MYC transcriptional regulation of TXNIP and HK2., PMID:39580129
Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2., PMID:39571460
FKBP4 promotes glycolysis and hepatocellular carcinoma progression via p53/HK2 axis., PMID:39505995
O-GlcNAcylation of hexokinase 2 modulates mitochondrial dynamics and enhances the progression of lung cancer., PMID:39496915
NEDD4L Inhibits the Proliferation and Migration of Keloid Fibroblasts by Regulating YY1 Ubiquitination-Mediated Glycolytic Metabolic Reprogramming., PMID:39494931
Notch signaling pathway suppresses mRNA expression of hexokinase 2 under nutrient-poor conditions in U87-MG glioma cells., PMID:39462157
Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease., PMID:39444028
Novel bibenzyl compound 8Ae induces apoptosis and inhibits glycolysis by detaching hexokinase 2 from mitochondria in A549 cells., PMID:39427530
Downregulation of hsa_circ_0006620 inhibits the malignant progression of prostate cancer by regulation of the miR-502-3p/HK2 axis mediated by aerobic glycolysis., PMID:39417968
Metabolic Reprogramming of CD4+ T Cells by Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuates Autoimmune Hepatitis Through Mitochondrial Protein Transfer., PMID:39345912
Paclitaxel-resistance facilitates glycolytic metabolism via Hexokinase-2-regulated ABC and SLC transporter genes in ovarian clear cell carcinoma., PMID:39341074
STING regulates aging-related osteoporosis by mediating the Hk2-Vdac1 mitochondrial axis., PMID:39326680
Neutrophil extracellular traps promote M1 macrophage polarization in gouty inflammation via targeting hexokinase-2., PMID:39277122
[Role of Notch 1 signaling and glycolysis in the pathogenic mechanism of adenomyosis]., PMID:39276056
Anti-Warburg Mechanism of Ginsenoside F2 in Human Cervical Cancer Cells via Activation of miR193a-5p and Inhibition of β-Catenin/c-Myc/Hexokinase 2 Signaling Axis., PMID:39273365
ETS1 drives EGF-induced glycolytic shift and metastasis of epithelial ovarian cancer cells., PMID:39159682
Resistant starch reduces glycolysis by HK2 and suppresses high-fructose corn syrup-induced colon tumorigenesis., PMID:39141107
CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension., PMID:39102213
For research use only. Not for human or drug use.
