Catalog No.
YHE91801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly46-Thr209
Predicted molecular weight
20.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P52333
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
L-JAK, Janus kinase 3, Leukocyte janus kinase, JAK-3, Tyrosine-protein kinase JAK3, JAK3
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance., PMID:40512406
Establishment and characterization of TK-DDCS1: a novel IDH1 mutated dedifferentiated chondrosarcoma cell line., PMID:40459681
Single-cell sequencing reveals shared clonal signatures in nonmalignant B and tumor cells in T-prolymphocytic leukemia., PMID:40453149
Orally effective FDA-approved protein kinase targeted covalent inhibitors (TCIs): A 2025 update., PMID:40451403
Pharmacophore Modeling of Janus Kinase Inhibitors: Tools for Drug Discovery and Exposition Prediction., PMID:40430355
Mucosal implications of oral Jak3-targeted drugs in COVID patients., PMID:40410684
Pentagalloyl glucose targets the JAK1/JAK3-STAT3 pathway to inhibit cancer stem cells and epithelial-mesenchymal transition in 5-fluorouracil-resistant colorectal cancer., PMID:40378534
A Multi-Level Study on the Anti-Lung Cancer Mechanism of Peiminine, a Key Component of Fritillaria ussuriensis Maxim.: Integrating Quality Analysis, Network Pharmacology, Bioinformatics Analysis, and Experimental Validation., PMID:40331978
Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism., PMID:40320905
Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancer., PMID:40298145
Identifying potent Janus kinase 3 inhibitors using structure-guided virtual screening for inflammatory and neoplastic disease therapy., PMID:40293172
Molecular characterization, expression, evolutionary analysis and molecular docking of the Janus activated kinase family members of largemouth bass (Micropterus salmoides)., PMID:40288622
Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia., PMID:40260377
Synergistic Anti-Cancer Activity of Melittin and Erlotinib in Non-Small Cell Lung Cancer., PMID:40243485
Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia., PMID:40234614
Efficacy and Safety of Zimlovisertib, Ritlecitinib, and Tofacitinib, Alone and in Combination, in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate., PMID:40223599
Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis., PMID:40216205
Computational insights of deucravacitinib's selectivity for TYK2 pseudokinase vs. JAK kinase domain via molecular modeling studies., PMID:40200906
JAK3 A573V and JAK3 M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway., PMID:40199606
Activity Regulation and Conformation Response of Janus Kinase 3 Mediated by Phosphorylation: Exploration from Correlation Network Analysis and Markov Model., PMID:40199555
[Identification of genes regulating human CAR-T cell proliferation by genome-wide CRISPR screening]., PMID:40175136
Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway., PMID:40170058
Malignant JAK-signaling: at the interface of inflammation and malignant transformation., PMID:40140631
Efficacy and safety of ritlecitinib in Asian patients with alopecia areata: A subgroup analysis of the ALLEGRO phase 2b/3 trial., PMID:40071721
IKZF1 and Ikaros Overexpression Results in Alopecia Areata-Like Phenotype in Mice., PMID:40066904
Synthesis and biological evaluation of thiourea-tethered benzodiazepinones as anti-proliferative agents targeting JAK-3 kinase., PMID:40029384
Characterization of the dual ITK/JAK3 small molecule covalent inhibitor ATI-2138., PMID:40023606
The role of LNK in mitigating hypertension: inhibition of vascular smooth muscle proliferation and JAK-STAT pathway., PMID:40014199
Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies., PMID:39975544
Patterns of clinical response in patients with alopecia areata treated with ritlecitinib in the ALLEGRO clinical development programme., PMID:39962358
Gender difference and BMDL exploration of developmental immunotoxicity induced by early-life low-dose exposure to 4-nonylphenol in Wistar rats., PMID:39961504
Protein tyrosine phosphatase nonreceptor 2: A New biomarker for digestive tract cancers., PMID:39958541
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway., PMID:39957706
Tofacitinib in alopecia areata and HIV: A curious intersection of immunomodulation, hair regrowth, and hypertrichosis., PMID:39901443
Identification of Thieno[3,2-d]pyrimidine derivatives as potent and selective Janus Kinase 1 inhibitors., PMID:39892337
Adipose Tissue-Derived Mesenchymal Stem Cells Regulate Th17/Treg Cells in a Rat Model of Allergic Rhinitis by Activating IL-2/JAK-3/STAT-5 Signaling Pathway., PMID:39864418
Ritlecitinib, a JAK3 /TEC inhibitor, modulates the markers of celiac autoimmunity in alopecia areata and vitiligo patients., PMID:39825945
JAK3 Inhibitors: Covalent and Noncovalent Interactions of a Cyanamide Group Investigated by Multiscale Free-Energy Simulations., PMID:39818786
Using patient preference to inform ritlecitinib dose selection for alopecia areata treatment., PMID:39812238
Epstein-Barr Virus BRRF1 Induces Butyrophilin 2A1 in Nasopharyngeal Carcinoma NPC43 Cells via the IL-22/JAK3-STAT3 Pathway., PMID:39769218
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy., PMID:39765290
Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target., PMID:39755448
CXCR2 Activated JAK3/STAT3 Signaling Pathway Exacerbating Hepatotoxicity Associated with Tacrolimus., PMID:39749191
Interaction between interleukin-12 (IL-12) and its receptor (IL-12Rβ2) mediates CD4+ T cell subsets activation in flounder (Paralichthys olivaceus)., PMID:39743087
Repositioning of drugs for the treatment of major depressive disorder based on prediction of drug-induced gene expression changes., PMID:39718103
Selective JAK1 inhibitors and the therapeutic applications thereof: a patent review (2016-2023)., PMID:39716925
Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway., PMID:39658572
Somatic genetic alterations of oncogenes and tumor suppressor genes in cholesteatoma., PMID:39648208
Proteomic profiling identifies classic Hodgkin lymphoma patients at risk of bleomycin pulmonary toxicity., PMID:39625996
A novel in silico approach for identifying multi-target JAK/STAT inhibitors as anticancer agents., PMID:39615248
For research use only. Not for human or drug use.
