Catalog No.
YHE90901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg35-Thr359
Predicted molecular weight
40.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51993
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fucosyltransferase 6, FUT6, Galactoside 3-L-fucosyltransferase, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6, FCT3A, FucT-VI, Fucosyltransferase VI, Fuc-TVI
Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis., PMID:39944529
N-glycan core tri-fucosylation requires Golgi α-mannosidase III activity that impacts nematode growth and behavior., PMID:39481603
Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank., PMID:39384777
FUT6 Suppresses the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Esophageal Carcinoma Cells via the Epidermal Growth Factor Receptor/Extracellular Signal-Regulated Kinase Signaling Pathway., PMID:39375968
Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori Infection., PMID:39108208
LncRNA PART1 promotes malignant biological behaviours associated with head and neck cancer cells via synergistic action with FUT6., PMID:38807207
Fucosyltransferases Regulated by Fusobacterium Nucleatum and Act as Novel Biomarkers in Colon Adenocarcinoma., PMID:36852302
Clinical relevance of vitamin B12 level and vitamin B12 metabolic gene variation in pulmonary tuberculosis., PMID:36275653
FUT6 inhibits the proliferation, migration, invasion, and EGF-induced EMT of head and neck squamous cell carcinoma (HNSCC) by regulating EGFR/ERK/STAT signaling pathway., PMID:36151332
A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma., PMID:35955933
Genetic regulation of post-translational modification of two distinct proteins., PMID:35332118
Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma., PMID:34703796
FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression., PMID:34215830
L1CAM as an E-selectin Ligand in Colon Cancer., PMID:33167483
The Sda Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition., PMID:32911675
Using Eukaryotic Expression Systems to Generate Human α1,3-Fucosyltransferases That Effectively Create Selectin-Binding Glycans on Stem Cells., PMID:32901486
Replication of 15 loci involved in human plasma protein N-glycosylation in 4802 samples from four cohorts., PMID:32521004
Detecting substrate glycans of fucosyltransferases with fluorophore-conjugated fucose and methods for glycan electrophoresis., PMID:32248235
Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis., PMID:32203219
Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis., PMID:31941930
Altered expression of fucosylation pathway genes is associated with poor prognosis and tumor metastasis in non‑small cell lung cancer., PMID:31894325
Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry., PMID:31860772
Carcinoembryonic antigen is a sialyl Lewis x/a carrier and an E‑selectin ligand in non‑small cell lung cancer., PMID:31793656
Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer., PMID:31676359
Defining the genetic control of human blood plasma N-glycome using genome-wide association study., PMID:31163085
Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis., PMID:30988423
Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines., PMID:30808544
HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway., PMID:30742932
Death receptor 5 is activated by fucosylation in colon cancer cells., PMID:30589515
Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans., PMID:30307499
α-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation., PMID:30226570
Production via good manufacturing practice of exofucosylated human mesenchymal stromal cells for clinical applications., PMID:30170815
The extended cytoplasmic tail of the human B4GALNT2 is critical for its Golgi targeting and post-Golgi sorting., PMID:30067891
Homing Genes Expression in Fucosyltransferase VI-Treated Umbilical Cord Blood CD133+ Cells which Expanded on Protein-Coated Nanoscaffolds., PMID:29730712
Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation., PMID:29215790
NFκB-mediated activation of the cellular FUT3, 5 and 6 gene cluster by herpes simplex virus type 1., PMID:28973293
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation., PMID:28878392
miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway., PMID:28771224
mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors., PMID:28481220
GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians., PMID:28334792
The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CAPN10, APM1 and FUT6 genes., PMID:27374856
MicroRNA-106b targets FUT6 to promote cell migration, invasion, and proliferation in human breast cancer., PMID:27519168
Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells., PMID:27335219
Comparisons of Caenorhabditis Fucosyltransferase Mutants Reveal a Multiplicity of Isomeric N-Glycan Structures., PMID:26538210
Bisecting Galactose as a Feature of N-Glycans of Wild-type and Mutant Caenorhabditis elegans., PMID:26002521
Transcriptional Downregulation by Nucleotide Substitution with the Minor Allele of rs3760776 Located in the Promoter of FUT6 Gene., PMID:25962326
Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines., PMID:25934648
A hybrid dynamic Bayesian network approach for modelling temporal associations of gene expressions for hypertension diagnosis., PMID:25570081
CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions., PMID:25339657
B4GALNT2 gene expression controls the biosynthesis of Sda and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract., PMID:24953560
For research use only. Not for human or drug use.
