Catalog No.
YHE90201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys125-Leu212
Predicted molecular weight
12.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51955
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NLK1, NEK2, NimA-like protein kinase 1, HSPK 21, NEK2A, Serine/threonine-protein kinase Nek2, NimA-related protein kinase 2, Never in mitosis A-related kinase 2
NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis., PMID:40481479
Sphingolipid synthesis in tumor-associated macrophages confers immunotherapy resistance in hepatocellular carcinoma., PMID:40397754
NEK2 Contributes to the Protection Against Cryptorchidism Outcomes., PMID:40386949
Cancer-associated fibroblast-derived fibulin-5 promotes epithelial-mesenchymal transition in diffuse-type gastric cancer via cAMP response element-binding protein pathway, showing poor prognosis., PMID:40369121
Integrative bioinformatic analysis identifies differentially expressed gene targets as potential biomarkers for anaplastic thyroid cancer., PMID:40350533
NEK2 inhibition alleviates lipopolysaccharide-induced endothelial injury., PMID:40259950
NEK2 supports porcine embryonic development by modulating the AKT signaling pathway., PMID:40239862
FOXA1 Targets NEK2 to Mediate Cisplatin Resistance in Lung Adenocarcinoma Cells by Activating DNA Damage Repair., PMID:40233258
NUF2 and NEK2 promote malignant progression of gallbladder cancer by remodeling the extracellular matrix., PMID:40220284
KLF15 regulates macrophage polarization patterns in deep vein thrombosis., PMID:40215780
Application of bioinformatics analysis and molecular docking to study the mechanism of Qingying decoction in treating psoriasis., PMID:40197419
Decoding Colorectal Cancer: Key Genes and Pathways in the Chinese Population Revealed., PMID:40183269
Microcystin-LR and its health impacts: Chemistry, transmission routes, mechanisms of toxicity and target organs., PMID:40177604
Exploring the anticancer potential of Jerantinine A from Tabernaemontana coronaria against prostate, breast, and ovarian cancers: a computational approach., PMID:40147045
NEK2 promotes the progression of osteosarcoma through the AKT/p-AKT pathway and interacts with FoxM1., PMID:40106063
Targeting NEK Kinases in Gastrointestinal Cancers: Insights into Gene Expression, Function, and Inhibitors., PMID:40076620
NEK2 inhibition reverses vascular remodeling in pulmonary arterial hypertension associated with congenital heart disease., PMID:40064279
Development and validation of a kinase-related gene signature as a novel diagnostic and prognostic model for prostate cancer., PMID:39965532
NEK2 Control of Esophageal Squamous Cell Carcinoma Growth Based on Circadian Oscillation., PMID:39963019
Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets., PMID:39935706
Identification of Immune Infiltration-Associated CC Motif Chemokine Ligands as Biomarkers and Targets for Colorectal Cancer Prevention and Immunotherapy., PMID:39859340
Insights into NEK2 inhibitors as antitumor agents: From mechanisms to potential therapeutics., PMID:39832390
Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability., PMID:39826695
NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells., PMID:39768163
NEK2 promotes the progression of osteoarthritis by stabilizing ATF2 through phosphorylation at Ser-112 and inhibiting autophagy., PMID:39693952
Phosphoproteomics guides low dose drug combination of cisplatin and silmitasertib against concurrent chemoradiation resistant cervical cancer., PMID:39665434
Mesenchymal stem cell-derived exosomes carrying miR-486-5p inhibit glycolysis and cell stemness in colorectal cancer by targeting NEK2., PMID:39506654
NEK2 is a potential pan-cancer biomarker and immunotherapy target., PMID:39505744
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway., PMID:39503194
NEK2 promotes colorectal cancer progression by activating the TGF-β/Smad2 signaling pathway., PMID:39499996
Unveiling novel prognostic biomarkers and therapeutic targets for HBV-associated hepatocellular carcinoma through integrated bioinformatic analysis., PMID:39470543
Flavonoids from Camellia oleifera flower ameliorate type 2 diabetes mellitus by regulating the p53 pathway., PMID:39428078
METTL3 facilitates the progression of cervical cancer by m6A modification-mediated up-regulation of NEK2., PMID:39424828
Exploring common pathogenic association between Epstein Barr virus infection and long-COVID by integrating RNA-Seq and molecular dynamics simulations., PMID:39391317
Comprehensive proteomics analysis reveals novel Nek2-regulated pathways and therapeutic targets in cancer., PMID:39368370
Novel insights into the circadian modulation of lipid metabolism in chicken livers revealed by RNA sequencing and weighted gene co-expression network analysis., PMID:39361997
Dynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in Dictyostelium amoebae., PMID:39329697
Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin., PMID:39271794
Identification of Hub Genes in Comorbidity of Psoriasis and Vitiligo Using Bioinformatics Analysis., PMID:39258216
Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation., PMID:39255311
Role of NEK2 in tumorigenesis and tumor progression., PMID:39181803
Exploration of biomarkers for nursing physical examination early screening of multiple tumors., PMID:39151523
The combination of RNA-seq transcriptomics and data-independent acquisition proteomics reveal the mechanisms and function of different gooses testicular development at different stages of laying cycle., PMID:39106693
[Ca2+]cyt-ASSOCIATED PROTEIN KINASE 1 and NIMA-RELATED KINASE 2 interact during root hair cell morphogenesis., PMID:39054117
Comprehensive analysis of aberrantly methylated differentially expressed genes and validation of CDC6 in melanoma., PMID:39052109
Prognostic value and immune infiltration of the NEK family in clear cell renal cell carcinoma., PMID:39029088
Anlotinib destabilizes PAX3-FOXO1 to induce rhabdomyosarcoma cell death via upregulating NEK2., PMID:38996706
Investigation on the molecular mechanism of SPA interference with osteogenic differentiation of bone marrow mesenchymal stem cells., PMID:38971916
In silico analysis unveiling potential biomarkers in gallbladder carcinogenesis., PMID:38914609
NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1., PMID:38795132
For research use only. Not for human or drug use.
