Catalog No.
YHE88101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu287-Gly523
Predicted molecular weight
29.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51813
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BMX, Epithelial and endothelial tyrosine kinase, Cytoplasmic tyrosine-protein kinase BMX, ETK, Bone marrow tyrosine kinase gene in chromosome X protein, NTK38
Discovery of IHMT-15130 as a Highly Potent Irreversible BMX Inhibitor for the Treatment of Myocardial Hypertrophy and Remodeling., PMID:40388356
Unravelling the Role of Insulin-Like Peptide Genes in Bombyx mori: Potential Key Regulators of Insect Metabolism., PMID:40235296
Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis., PMID:40230692
Lactylation-driven USP4-mediated ANXA2 stabilization and activation promotes maintenance and radioresistance of glioblastoma stem cells., PMID:40185997
Understanding the Role of Rho GTPase Activating Protein and Bone Marrow Kinase X: A Novel Target in Gastric Cancer Treatment., PMID:40156387
The Super Enhancer-Driven Long Noncoding RNA PRKCQ-AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds., PMID:40103284
Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer., PMID:40085024
Design, Synthesis, and Mechanism Study of Novel BMX Inhibitors Based on the Core of 1,3,5-Triazin-2-Amine for the Treatment of Gastric Carcinoma., PMID:39953991
Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8., PMID:39461476
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma., PMID:39133652
Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis., PMID:38442328
BMX deletion mitigates neuroinflammation induced by retinal ischemia/reperfusion through modulation of the AKT/ERK/STAT3 signaling cascade., PMID:38434304
Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design., PMID:38275417
Target Occupancy and Functional Inhibition of JAK3 and TEC Family Kinases by Ritlecitinib in Healthy Adults: An Open-Label, Phase 1 Study., PMID:37691236
Vamorolone improves Becker muscular dystrophy and increases dystrophin protein in bmx model mice., PMID:37534133
BMX-A and BMX-S: Accessible cell-free methods to estimate peptide-MHC-I affinity and stability., PMID:37478775
2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling., PMID:37437350
Transcriptomic analysis of neutrophil apoptosis induced by diffuse large B-cell lymphoma unveils a potential role in neutropenia., PMID:37266765
Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis., PMID:37180171
Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress., PMID:37047131
A phosphorylation switch controls androgen biosynthesis in prostate cancer., PMID:36647834
BMX controls 3βHSD1 and sex steroid biosynthesis in cancer., PMID:36647826
The X-linked Becker muscular dystrophy (bmx) mouse models Becker muscular dystrophy via deletion of murine dystrophin exons 45-47., PMID:36628607
BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death., PMID:36575468
Predicting BMX Performance with Laboratory Measurements in Elite Riders., PMID:36573934
Feeding injury of major lepidopteran soybean pests in South America., PMID:36520803
BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors., PMID:35797240
Rotenone-Induced 4-HNE Aggresome Formation and Degradation in HL-1 Cardiomyocytes: Role of Autophagy Flux., PMID:35563066
Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease., PMID:35296647
Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis., PMID:35221332
Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts., PMID:35000411
Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia., PMID:34962102
CHMFL-BMX-078, a BMX inhibitor, overcomes the resistance of melanoma to vemurafenib via inhibiting AKT pathway., PMID:34813779
Reactivities of the Front Pocket N-Terminal Cap Cysteines in Human Kinases., PMID:34647463
Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx., PMID:34536556
Efficacy and safety of palbociclib in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with preexisting conditions: A post hoc analysis of PALOMA-2., PMID:34388698
Designing a novel photoinduced electron transfer-based small-molecule fluorescent probe specific for CYP3A isozymes., PMID:34119614
NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition., PMID:34072831
Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma., PMID:33863808
H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways., PMID:33815656
Inhibitory efficacy of RNA virus drugs against SARS-CoV-2 proteins: An extensive study., PMID:33678903
Tumor-Derived Pericytes Driven by EGFR Mutations Govern the Vascular and Immune Microenvironment of Gliomas., PMID:33593822
Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK., PMID:33291717
Muscle Typology of World-Class Cyclists across Various Disciplines and Events., PMID:33105386
A scalable insect cell-based production process of the human recombinant BMX for in-vitro covalent ligand high-throughput screening., PMID:32816073
Biochemical Profile of the Soybean Seed Embryonic Axis and Its Changes during Accelerated Aging., PMID:32717802
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors., PMID:32613545
The use of accelerometry to evaluate the BMX cycling starting hill. Effect of the Q-Ring™ on the acceleration profile., PMID:32567482
Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo., PMID:32479589
Multi-Targeting Bioactive Compounds Extracted from Essential Oils as Kinase Inhibitors., PMID:32384767
For research use only. Not for human or drug use.
