Catalog No.
YHE80201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Cys207
Predicted molecular weight
25.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51149
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RAB7A, RAB7, Ras-related protein Rab-7a
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia., PMID:40388337
[Inhibition of ISO-induced hypertrophy and damage in H9c2 cells by total saponins from Ginseng Radix et Rhizoma and Notoginseng Radix et Rhizoma via promoting autophagy]., PMID:40350876
[Transcriptomic analysis of suspended Vero cells and reduction of cellular autophagy by epidermal growth factor]., PMID:40328724
RabGAP1L modulates Rab7A and Rab10 to orchestrate cell-autonomous immunity., PMID:40244851
Methamphetamine and Methamphetamine-Induced Neuronal Exosomes Modulate the Activity of Rab7a via PTEN to Exert an Influence on the Disordered Autophagic Flux Induced in Neurons., PMID:40141286
Evidence for Rab7b and Its Splice Isoforms Having Distinct Biological Functions from Rab7a., PMID:40141252
Lactate accumulation drives hepatocellular carcinoma metastasis through facilitating tumor-derived exosome biogenesis by Rab7A lactylation., PMID:40120799
Identification of a novel FOXO3‑associated prognostic model in hepatocellular carcinoma., PMID:40114746
Artemetin targets the ABCG2/RAB7A axis to inhibit mitochondrial dysfunction in asthma., PMID:40088742
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma., PMID:40055185
Investigating the impact of Ras-related protein RAB7A on colon adenocarcinoma behavior and its clinical significance., PMID:39927685
Two-pore channel regulators - Who is in control?, PMID:39867224
The Type III Intermediate Filament Protein Peripherin Regulates Lysosomal Degradation Activity and Autophagy., PMID:39859265
TPC2 controls MITF expression and metastasis in melanoma., PMID:39740384
TPC2: From Blond Hair to Melanoma?, PMID:39682251
USP4 depletion-driven RAB7A ubiquitylation impairs autophagosome-lysosome fusion and aggravates periodontitis., PMID:39663592
A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance., PMID:39630893
Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway., PMID:39627812
Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment., PMID:39584231
Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis., PMID:39562548
Proteomics reveals that nanoplastics with different sizes induce hepatocyte apoptosis in mice through distinct mechanisms involving mitophagy dysregulation and cell cycle arrest., PMID:39539253
Histone deacetylase inhibition disrupts the molecular signature of the glioblastoma secretome related to extracellular vesicle-associated proteins and targets RAB7a and RAB14 in vitro., PMID:39454304
Standard chemotherapy impacts on in vitro cellular heterogeneity in spheroids enriched with cancer stem cells (CSCs) derived from triple-negative breast cancer cell line., PMID:39357337
Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer Cells., PMID:39313937
Comprehensive analysis of the mRNA and miRNA transcriptome implicated in the immune response of Procambarus clarkii to Spiroplasma eriocheiris., PMID:39270754
Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic., PMID:39181128
GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes., PMID:39056394
RAB22A sorts epithelial growth factor receptor (EGFR) from early endosomes to recycling endosomes for microvesicles release., PMID:39051763
Comprehensive knockout analysis of the RAB family small GTPases reveals an overlapping role of RAB2 and RAB14 in autophagosome maturation., PMID:38953305
Differential response of placental cells to high D-glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras-related protein RAB-7A., PMID:38938672
The Prognostic Biomarker RAB7A Promotes Growth and Metastasis of Liver Cancer Cells by Regulating Glycolysis and YAP1 Activation., PMID:38924128
SIRT5-Mediated Desuccinylation of RAB7A Protects Against Cadmium-Induced Alzheimer's Disease-Like Pathology by Restoring Autophagic Flux., PMID:38837686
Revealing potential Rab proteins participate in regulation of secretory autophagy machinery., PMID:38804615
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy., PMID:38728007
Deregulated expression of autophagy genes; PIK3C3 and RAB7A in COVID-19 patients., PMID:38609772
Collapse of late endosomal pH elicits a rapid Rab7 response via the V-ATPase and RILP., PMID:38578235
Reversible assembly and disassembly of V-ATPase during the lysosome regeneration cycle., PMID:38446621
Release of extracellular vesicles triggered by low-intensity pulsed ultrasound: immediate and delayed reactions., PMID:38410045
Phylogenomic, structural, and cell biological analyses reveal that Stenotrophomonas maltophilia replicates in acidified Rab7A-positive vacuoles of Acanthamoeba castellanii., PMID:38319117
Comparative proteomics reveals different protein expression in platelets in patients with alcoholic liver cirrhosis., PMID:38279183
A genome-wide CRISPR/Cas9 screen identifies a role for Rab5A and early endosomes in hepatitis E virus replication., PMID:38109552
AoRab7A interacts with AoVps35 and AoVps41 to regulate vacuole assembly, trap formation, conidiation, and functions of proteasomes and ribosomes in Arthrobotrys oligospora., PMID:38103468
Proteomics analysis of serum and urine identifies VCP and CTSA as potential biomarkers associated with multiple myeloma., PMID:38081446
[High expression of RAB7A is associated with poor prognosis of gastric cancer by promoting tumor invasion]., PMID:37933649
Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis., PMID:37820423
Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation., PMID:37794304
Rab7a activation promotes degradation of select tight junction proteins at the blood-brain barrier after ischemic stroke., PMID:37693406
Identification of differentially expressed proteins in heart of mouse death from smother based on label-free proteomics., PMID:37549592
The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)., PMID:37418591
For research use only. Not for human or drug use.
