Catalog No.
YHE77701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu533-Glu731
Predicted molecular weight
25.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P50570
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNM2, Dynamin-2, DYN2
Endophilin A1 and synaptojanin 1-dependent endocytosis of synaptic vesicles in nociceptive spinal circuits maintains postoperative and cancer pain., PMID:40488273
Combining dynamin 2 myopathy and neuropathy mutations rescues both phenotypes., PMID:40393994
Inhibiting mitochondrial excessive fission alleviates the neuronal damage in Parkinson's disease via regulating PGC-1α mediated mitochondrial biogenesis., PMID:40320116
BIN1 gene replacement reverses BIN1-related centronuclear myopathy., PMID:40308061
Liver function in X-linked myotubular myopathy and autosomal dominant centronuclear myopathy: Data of the unite-CNM study., PMID:40275672
Evaluation of dynamin 2 knockdown as a therapeutic strategy for RYR1 related myopathy., PMID:40273816
A novel DNM2 variant associated with centronuclear myopathy: a case report., PMID:40259930
Heat shock protein 60 manipulates Foot-and-Mouth disease virus replication by regulating mitophagy., PMID:40192762
The synaptic availability of GluA1 is reduced in hippocampal neurons of a murine model of dynamin-2 linked autosomal dominant centronuclear myopathy., PMID:40170502
Disease Trajectories of a Large French Cohort of 142 Congenital Myopathy Patients in Adult Age., PMID:40159620
Danqi soft caspule alleviates myocardial ischemia-reperfusion injury induced cardiomyocyte apoptosis by attenuating mitochondrial fission., PMID:40144667
Glucagon-like peptide-1 receptor signaling activation in alveolar type II cells enhances lung development in neonatal rats exposed to hyperoxia., PMID:40080965
SH3KBP1 promotes skeletal myofiber formation and functionality through ER/SR architecture integrity., PMID:40065183
BIN1 reduction ameliorates DNM2-related Charcot-Marie-Tooth neuropathy., PMID:40042903
Restoring Vascular Smooth Muscle Cell Mitochondrial Function Attenuates Abdominal Aortic Aneurysm in Mice., PMID:39945066
Astragali Radix-Notoginseng Radix et Rhizoma medicine pair prevents cardiac remodeling by improving mitochondrial dynamic balance., PMID:39855831
Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner., PMID:39825424
Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy., PMID:39795939
Potential compensatory mechanisms preserving cardiac function in myotubular myopathy., PMID:39625536
Nuclear Expression of Dynamin 2 Is Associated With Tumor Aggressiveness in Bladder Cancer Patients: A Bioinformatics and Experimental Approach., PMID:39610009
Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks., PMID:39580802
Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells., PMID:39533399
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation., PMID:39511597
Improving the Cellular Internalization of Zr(IV) Nanocages by Tuning Hydrophilicity and Lipophilicity., PMID:39482252
Mitochondrial mechanotransduction through MIEF1 coordinates the nuclear response to forces., PMID:39433949
ZIP4: a promising early diagnostic and therapeutic targets for pancreatic cancer., PMID:39417191
Effect of Pathogenic Mutations on the Formation of High-Order Dynamin 2 Assemblies in Living Cells., PMID:39390788
Effect of phosphatase and tensin homolog-induced putative kinase 1/ E3 ubiquitin ligase Parkin mediated mitochondrial autophagy on chronic kidney disease myocardial injury and the intervention mechanism of Shenshuai recipe., PMID:39380224
IDH1/MDH1 deacetylation promotes NETosis by regulating OPA1 and autophagy., PMID:39353390
Spatial and signaling overlap of growth factor receptor systems at clathrin-coated sites., PMID:39292879
Validation of Active Compound of Terminalia catappa L. Extract and Its Anti-Inflammatory and Antioxidant Properties by Regulating Mitochondrial Dysfunction and Cellular Signaling Pathways., PMID:39252640
Dynamin 2-mediated endocytosis of BLT1 is required for IL-8 production in HMC-1 cells induced by Trichomonas vaginalis-derived secretory products., PMID:39218627
Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses., PMID:39169044
Candidate proteins interacting with cytoskeleton in cells from the basal airway epithelium in vitro., PMID:39139811
The host GTPase Dynamin 2 modulates apical junction structure to control cell-to-cell spread of Listeria monocytogenes., PMID:39133017
Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway., PMID:39127116
Dynamin-2 mutations linked to neonatal-onset centronuclear myopathy impair exocytosis and endocytosis in adrenal chromaffin cells., PMID:39126680
PKCα Induced the Generation of Extracellular Vesicles in Activated Platelets to Promote Breast Cancer Metastasis., PMID:39113702
PINK1 insufficiency can be exploited as a specific target for drug combinations inducing mitochondrial pathology-mediated cell death in gastric adenocarcinoma., PMID:39103009
Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy., PMID:38995680
Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis., PMID:38948095
Gangliosides in neural stem cell fate determination and nerve cell specification--preparation and administration., PMID:38915682
A clathrin mediated endocytosis scaffolding protein, Intersectin 1, changes in an isoform, brain region, and sex specific manner in Alzheimer's disease., PMID:38915309
Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry., PMID:38860570
Dynamin-dependent entry of Chlamydia trachomatis is sequentially regulated by the effectors TarP and TmeA., PMID:38858371
Ohwia caudata inhibits doxorubicin-induced cardiotoxicity by regulating mitochondrial dynamics via the IGF-IIR/p-Drp1/PARP signaling pathway., PMID:38837810
Discovery of Pathogenic Variants Associated with Idiopathic Recurrent Pregnancy Loss Using Whole-Exome Sequencing., PMID:38791485
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation., PMID:38724689