Catalog No.
YHE69701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu376-Phe482
Predicted molecular weight
13.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49757
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein S171, Protein numb homolog, NUMB, C14orf41, h-Numb
The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels., PMID:40411418
PP2A Promotes the Symmetric Division of MUC1-Dominant Cancer Stem-Like Cells in Small Cell Lung Cancer., PMID:40349179
Expression of NUMB Protein and Its Prognostic Significance in Endometrial Cancer: A Retrospective Cohort Study., PMID:40296944
Differential neuronal functions of LNX1 and LNX2 revealed by behavioural analysis in single and double knockout mice., PMID:40269869
Curcumin prevents dexamethasone-induced activation of the pseudorabies virus in rat pheochromocytoma cells through the miR-155-5p-Aak1-Numb/Notch2 signalling axis., PMID:40259414
Latest News from the "Guardian": p53 Directly Activates Asymmetric Stem Cell Division Regulators., PMID:40243948
Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading., PMID:40241749
Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut., PMID:40202131
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)., PMID:40122662
NUMB alternative splicing and isoform-specific functions in development and disease., PMID:39863103
VISTA-induced tumor suppression by a four amino acid intracellular motif., PMID:39803490
Expression and clinical significance of Numb and Notch-1 proteins between tissue of colon cancer and regional lymph node metastases., PMID:39691600
Numb family proteins play roles in Desmin and Vimentin localization at the Z-disc., PMID:39674848
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis., PMID:39627202
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis., PMID:39609404
Numb and NumbL inhibit melanoma tumor growth by influencing the immune microenvironment., PMID:39558287
Pancancer analysis of the interactions between CTNNB1 and infiltrating immune cell populations., PMID:39495984
RAB4A is a master regulator of cancer cell stemness upstream of NUMB-NOTCH signaling., PMID:39463384
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout., PMID:39433541
Maternal serum Numb in the first trimester of pregnancy as a biomarker for early prediction of pre-eclampsia: A prospective cohort study., PMID:39425599
Numb Suppresses Notch-Dependent Activation of Enhancer of split during Lateral Inhibition in the Drosophila Embryonic Nervous System., PMID:39334829
NUMB attenuates posttraumatic osteoarthritis by inhibiting BTRC and inactivating the NF-κB pathway., PMID:39175086
The impact of NUMB on chicken abdominal adipogenesis: A comprehensive analysis., PMID:39168214
[Pricking-cupping combined with auricular thumbtack needle for postherpetic neuralgia of qi stagnation and blood stasis on chest and waist: a randomized controlled trial]., PMID:39111788
MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progression., PMID:39097735
Numb-associated kinases regulate sandfly-borne Toscana virus entry., PMID:39017647
Rhodojaponin VI ameliorates podocyte injury related with MDM2/Notch1 pathway in rat experimental membranous nephropathy., PMID:39011853
Stem Cell Division and Its Critical Role in Mammary Gland Development and Tumorigenesis: Current Progress and Remaining Challenges., PMID:38943275
Transcription factor FOXF2 promotes the development and progression of pancreatic cancer by targeting MSI2., PMID:38847273
Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function., PMID:38695862
Numb positively regulates Hedgehog signaling at the ciliary pocket., PMID:38664376
Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway., PMID:38532427
Development of a novel AAK1 inhibitor via Kinobeads-based screening., PMID:38509168
Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1., PMID:38437016
NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells., PMID:38409448
NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition., PMID:38396553
Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome with dilated cardiomyopathy: A case report., PMID:38322456
The PTB and PRR domains of numb regulate neurite outgrowth by influencing voltage-gated calcium channel expression and kinetics., PMID:38215950
Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma., PMID:38184733
Botulinum toxin type A improves pain in numb chin syndrome., PMID:38159684
SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling., PMID:37843276
Noncanonical regulation of HOIL-1 on cancer stemness and sorafenib resistance identifies pixantrone as a novel therapeutic agent for HCC., PMID:37820061
Reversing Uteropathies Including Cancer-Like Changes in Mice by Transplanting Mesenchymal Stromal Cells or XAR Treatment., PMID:37779174
ZFP64 Promotes Gallbladder Cancer Progression through Recruiting HDAC1 to Activate NOTCH1 Signaling Pathway., PMID:37760477
Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes., PMID:37759347
Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway., PMID:37702916
Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors., PMID:37657045
Palmitic acid promotes human retinal pigment epithelial cells migration by upregulating miR-222 expression and inhibiting NUMB., PMID:37566749
Hypereosinophilic Syndrome with Endomyocarditis: Identification by Next-Generation Sequencing of the JAK2-V617F Mutation., PMID:37470384
SEPTIN 7 INTERACTS WITH NUMB TO PRESERVE SARCOMERE STRUCTURAL ORGANIZATION AND MUSCLE CONTRACTILE FUNCTION., PMID:37461567
For research use only. Not for human or drug use.
