Catalog No.
YHE67601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn78-Glu265
Predicted molecular weight
23.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49662
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mih1, ICH2, CASP-4, ICE and Ced-3 homolog 2, CASP4, Protease TX, Caspase-4, ICE(rel)-II, ICH-2
Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer's Disease Pathologies., PMID:40497980
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease., PMID:40393978
Qilian Jiechang Ning Alleviates TNBS-Induced Ulcerative Colitis in Mice and Segatella copri Outer Membrane Vesicle-Triggered Inflammation in Colon Epithelial Cells via the Caspase-1/11-GSDMD Pathways., PMID:40367931
Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium., PMID:40355718
NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria., PMID:40272180
Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages., PMID:40162563
LXR agonists induces GSDME-mediated pyroptosis in tumors through alters the integrity of the MOM to activates Caspase-4/APAF-1 pyroptosome., PMID:40154703
The Role of Caspase-1 and Caspase-4 in Modulating Gingival Epithelial Cell Responses to Aggregatibacter actinomycetemcomitans Infection., PMID:40137780
A Site-Specific Photo-Crosslinking Proteomics Approach Provides Insights into Noncanonical Pyroptotic Caspase-4 Substrates., PMID:40070324
Cross-kingdom-mediated detection of intestinal protozoa through NLRP6., PMID:40043701
Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing mitochondrial ROS production., PMID:40034692
A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome., PMID:39998486
Overexpression of inflammatory human caspase-4 in relation to clinical severity of oral lichen planus., PMID:39979138
IL-27 aggravates acute hepatic injury by promoting macrophage M1 polarization to induce Caspase-11 mediated Pyroptosis in vitro and in vivo., PMID:39913960
Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection., PMID:39823227
Inhibition of RIPK1-driven necroptosis ameliorates inflammatory hyperalgesia caused by lipopolysaccharide: involvement of TLR-, NLRP3-, and caspase-11-mediated signaling pathways., PMID:39799497
Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages., PMID:39769989
Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury., PMID:39744431
Dexmedetomidine Mitigates Acute Lung Injury by Enhancing M2 Macrophage Polarization and Inhibiting RAGE/Caspase-11-Mediated Pyroptosis., PMID:39735987
A complex of NLRP3 with caspase-4 is essential for inflammasome activation by Tannerella forsythia infection., PMID:39673522
SENP1 Promotes Caspase-11 Inflammasome Activation and Aggravates Inflammatory Response in Murine Acute Lung Injury Induced by Lipopolysaccharide., PMID:39614435
Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii., PMID:39533032
A type VI secretion system in Burkholderia species cenocepacia and orbicola triggers distinct macrophage death pathways independent of the pyrin inflammasome., PMID:39480100
Long-Lasting, Fine-Tuned Anti-Tumor Activity of Recombinant Listeria monocytogenes Vaccine Is Controlled by Pyroptosis and Necroptosis Regulatory and Effector Molecules., PMID:39452700
Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release., PMID:39428744
Neisseria meningitidis activates pyroptotic pathways in a mouse model of meningitis: role of a two-partner secretion system., PMID:39376663
Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury., PMID:39333859
ROLE OF CASPASE-1/CASPASE-11-HMGB1-RAGE/TLR4 SIGNALING IN THE EXACERBATION OF EXTRAPULMONARY SEPSIS-INDUCED LUNG INJURY BY MECHANICAL VENTILATION., PMID:39228020
Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection., PMID:39179968
Plexin C1 influences immune response to intracellular LPS and survival in murine sepsis., PMID:39169397
Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis., PMID:39143049
Caspase-4 in glioma indicates deterioration and unfavorable prognosis by affecting tumor cell proliferation and immune cell recruitment., PMID:39075190
TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1., PMID:39059206
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis., PMID:39029644
Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity., PMID:39024553
Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection., PMID:38936554
Inhibition of caspase-11 under inflammatory conditions suppresses chondrogenic differentiation., PMID:38875922
Microglia Caspase11 non-canonical inflammasome drives fever., PMID:38864370
Caspase-4 promotes metastasis and interferon-γ-induced pyroptosis in lung adenocarcinoma., PMID:38849594
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown., PMID:38632402
Adipose tissue IL-18 production is independent of caspase-1 and caspase-11., PMID:38629728
Fluoride induces pyroptosis via IL-17A-mediated caspase-1/11-dependent pathways and Bifidobacterium intervention in testis., PMID:38554964
Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis., PMID:38532152
Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis., PMID:38493291
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis., PMID:38484431
Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma., PMID:38459541
Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection., PMID:38422126
Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS., PMID:38413746
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease., PMID:38326859
Role of Histiocyte-Derived frHMGB1 as a Facilitator in Noncanonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis., PMID:38243905
For research use only. Not for human or drug use.
