Catalog No.
YHE65101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp3-Thr246
Predicted molecular weight
30.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49407
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARRB1, Beta-arrestin-1, Non-visual arrestin-2, ARR1, Arrestin beta-1
β-suppressor protein 1 (ARRB1)-△exon13 modulates the progression of glioblastoma via combination with glycolysis-related proteins., PMID:40486495
A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE., PMID:40446798
P300-Mediated ARRB1 Lactylation Promotes Mitochondrial Dysfunction and Neuronal Apoptosis in Subarachnoid Hemorrhage Via Upregulating S100A9., PMID:40445496
Lipids modulate the dynamics of GPCR:β-arrestin interaction., PMID:40442125
LSM12 promotes the lung squamous cell carcinoma progression through mediating alternative splicing of ARRB1., PMID:40425760
β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and IFT machinery., PMID:40384633
Transcriptome-Wide Analysis and Experimental Validation from FFPE Tissue Identifies Stage-Specific Gene Expression Profiles Differentiating Adenoma, Carcinoma In-Situ and Adenocarcinoma in Colorectal Cancer Progression., PMID:40362431
A bioinformatics exploration of lung adenocarcinoma identifies hub genes with prognostic significance: from data to discovery., PMID:40320470
β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function., PMID:40236194
Decoding Proteomic cross-talk between hypobaric and normobaric hypoxia: Integrative analysis of oxidative stress, cytoskeleton remodeling, and inflammatory pathways., PMID:40187642
Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction., PMID:40151398
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator., PMID:40118988
MiR-326: Role and significance in brain cancers., PMID:40115178
cFos-mediated β-Arrestin1 in the RVLM alleviates sympathetic hyperactivity induced by ovariectomy., PMID:40096880
From metabolic regulation to kidney protection: β-arrestin 2 as a dual-function therapeutic target., PMID:40093274
The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts., PMID:39985042
Regulation of GLP-1 and Glucagon Receptor Function by β-Arrestins in Metabolically Important Cell Types., PMID:39983043
IGF1R/ARRB1 Mediated Regulation of ERK and cAMP Pathways in Response to Aβ Unfolds Novel Therapeutic Avenue in Alzheimer's Disease., PMID:39969678
β-arrestin 1 and integrin-linked kinase interact in epidermal keratinocytes and regulate cell motility., PMID:39945280
Novel role of GRK2 in isoprenaline-induced activation of Na+/H+ exchanger 3 independent of β2-adrenergic receptor signaling., PMID:39932653
N-homocysteinylation of β-arrestins biases GPCR signaling and promotes platelet activation., PMID:39928858
Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery., PMID:39755133
Differential effects of liraglutide naltrexone/bupropion, and caloric restriction on metabolic parameters and beta-cell regeneration in type 2 diabetic rat model: role of beta arrestin 1., PMID:39704859
Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement., PMID:39623381
Structural plasticity of arrestin-G protein coupled receptor complexes as a molecular determinant of signaling., PMID:39515728
Receptor Determinants for β-Arrestin Functional Specificity at C-X-C Chemokine Receptor 5., PMID:39472027
Location-biased β-arrestin conformations direct GPCR signaling., PMID:39386521
The stimulatory effect of HI 129, a novel indole derivative, on glucose-induced insulin secretion., PMID:39326678
Electroacupuncture alleviates neuropathic pain by regulating hippocampal SP/NK1R/ARRB1 pathway., PMID:39318312
Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence., PMID:39315447
Human and Mouse Nephrin and Their Interactions With 13 Proteins: An In Silico Study., PMID:39246878
β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 transcription to drive parkin-dependent mitophagy in colitis., PMID:39246845
A New Piece to the AMPK Puzzle in Heart Repair: Phosphorylation of β-Arrestin-1., PMID:39208127
Retraction: β-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase., PMID:39177107
Antagonism of β-arrestins in IL-4-driven microglia reactivity via the Samd4/mTOR/OXPHOS axis in Parkinson's disease., PMID:39167645
High throughput mRNA sequencing reveals potential therapeutic targets of Si-Ni-San in the pons for a stress-induced depression model., PMID:39135796
Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy., PMID:39131402
AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330., PMID:39082138
Conformational dynamics underlying atypical chemokine receptor 3 activation., PMID:39008676
GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress., PMID:39001944
Identification of exosomal microRNAs and related hub genes associated with imatinib resistance in chronic myeloid leukemia., PMID:38916832
Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction., PMID:38889722
Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons., PMID:38883814
[Screening and functional analysis of differentially expressed long non-coding RNA in the liver of mice infected with Schistosoma japonicum during the chronic pathogenic stage]., PMID:38857956
ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration., PMID:38838859
The β-arrestin1/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential., PMID:38777849
AlloViz: A tool for the calculation and visualisation of protein allosteric communication networks., PMID:38736696
Arrestin beta 1 Regulates Alveolar Progenitor Renewal and Lung Fibrosis., PMID:38736470
Differential contributions of G protein- or arrestin subtype-mediated signalling underlie urocortin 3-induced somatostatin secretion in pancreatic δ cells., PMID:38613153
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor., PMID:38600384
For research use only. Not for human or drug use.
