Catalog No.
YHE63701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro198-Cys475
Predicted molecular weight
34.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P49257
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LMAN1, Protein ERGIC-53, Lectin mannose-binding 1, ERGIC53, Intracellular mannose-specific lectin MR60, ER-Golgi intermediate compartment 53 kDa protein, Gp58, F5F8D
Combined deficiency of factor V and factor VIII in a pediatric patient: a case report., PMID:40296097
LMAN1 serves as a cargo receptor for thrombopoietin., PMID:39499573
RNAi targeting LMAN1-MCFD2 complex promotes anticoagulation in mice., PMID:39222205
Clinical, Laboratory, Molecular, and Reproductive Aspects of Combined Deficiency of Factors V and VIII., PMID:39209292
A Novel Variant of the LMAN1 Gene in Combined Factor V and Factor VIII Deficiency in a Saudi Female Child: A Case Report., PMID:38659545
Identification of LMAN1- and SURF4-Dependent Secretory Cargoes., PMID:37844105
Mammalian cargo receptors for endoplasmic reticulum-to-Golgi transport: mechanisms and interactions., PMID:37334845
Identification of LMAN1 and SURF4 dependent secretory cargoes., PMID:37066360
LMAN1 is a receptor for house dust mite allergens., PMID:36870056
Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases., PMID:36594468
Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII., PMID:36490287
Combined Factor V and VIII Deficiency with LMAN1 Mutation: A Report of 3 Saudi Siblings., PMID:36116005
Bioinformatics analysis of LMAN1 expression, clinical characteristics, and its effects on cell proliferation and invasion in glioma., PMID:35623391
Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors., PMID:35477478
LMAN1-MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin., PMID:35322856
GRP75 as a functional element of cholix transcytosis., PMID:35262466
A distinct common p.Gln317* mutation among causative LMAN1 genetic mutations of combined factor V and factor VIII deficiency in five Taiwanese families., PMID:34766420
[Combined deficiency of clotting factor V and factor VIII: about three siblings]., PMID:34422188
A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function., PMID:34350936
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers., PMID:34010647
Genome-wide association study of cardiac troponin I in the general population., PMID:33961016
Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis., PMID:33848642
Quantitative STAU2 measurement in lymphocytes for breast cancer risk assessment., PMID:33441653
[Comparative study of the human keratinocytes proteome of the HaCaT line: identification of proteins encoded by genes of 18 chromosomes under the influence of detergents]., PMID:33372905
Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression., PMID:33196840
Perinatal protein malnutrition results in genome-wide disruptions of 5-hydroxymethylcytosine at regions that can be restored to control levels by an enriched environment., PMID:33172347
Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score., PMID:32887899
Hepatitis B Virus Exploits ERGIC-53 in Conjunction with COPII to Exit Cells., PMID:32806600
The plasma peptides of sepsis., PMID:32636717
Crystallographic snapshots of the EF-hand protein MCFD2 complexed with the intracellular lectin ERGIC-53 involved in glycoprotein transport., PMID:32356523
Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor., PMID:32170195
Cholix protein domain I functions as a carrier element for efficient apical to basal epithelial transcytosis., PMID:31928299
Low factor V level ameliorates bleeding diathesis in patients with combined deficiency of factor V and factor VIII., PMID:31558466
Genetic Study on Small Insertions and Deletions in Psoriasis Reveals a Role in Complex Human Diseases., PMID:31078570
LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors., PMID:30791981
[Congenital factor V and factor VIII deficiency discovered in an elderly patient with abnormal bleeding after trauma]., PMID:29743396
Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo., PMID:29735583
Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer., PMID:29679592
Dimeric sorting code for concentrative cargo selection by the COPII coat., PMID:29555761
Proteomics reveals changes in hepatic proteins during chicken embryonic development: an alternative model to study human obesity., PMID:29310583
Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family., PMID:29082580
Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway., PMID:28157181
The T cell IFT20 interactome reveals new players in immune synapse assembly., PMID:28154159
Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma., PMID:27765924
A Human Lectin Microarray for Sperm Surface Glycosylation Analysis., PMID:27364157
Release of Vesicular Stomatitis Virus Spike Protein G-Pseudotyped Lentivirus from the Host Cell Is Impaired upon Low-Density Lipoprotein Receptor Overexpression., PMID:26339060
Successful abdominal operation without replacement therapy in a patient with combined factor V (FV) and FVIII deficiency due to novel homozygous mutation in LMAN1., PMID:26193913
LMAN1 (ERGIC-53) is a potential carrier protein for matrix metalloproteinase-9 glycoprotein secretion., PMID:26150355
Murine coagulation factor VIII is synthesized in endothelial cells., PMID:24719406
For research use only. Not for human or drug use.
