Catalog No.
YHE60801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala40-Gln452
Predicted molecular weight
48.92 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P48735
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Isocitrate dehydrogenase [NADP], mitochondrial, IDH2, IDH, ICD-M, NADP(+)-specific ICDH, IDP, Oxalosuccinate decarboxylase
ATRX loss in adult gliomas lacking H3 alterations or IDH mutations, an exceptional situation for exceptional diagnoses: the experience of Sainte-Anne hospital., PMID:40514723
[Update of molecular pathology in cartilage tumors]., PMID:40494758
Succinate Accumulation Accelerates Oxidative Stress to Promote Pulmonary Epithelial Cell Apoptosis During Lung Ischemia-Reperfusion Injury., PMID:40484976
Multiomics analysis uncovers host-microbiota interactions regulate hybrid vigor traits in geese., PMID:40393267
Affinity-Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor-Independent Neuroprotection., PMID:40388656
HMGA2 is an independent prognostic indicator and a potential therapeutic target for IDH-mutant astrocytoma., PMID:40379848
Genetic re-classification of combined hepatocellular-cholangiocarcinoma and small duct type intrahepatic cholangiocarcinoma., PMID:40349569
[Metabolism and therapy in acute myeloid leukemia with isocitrate dehydrogenase 1/2 mutations]., PMID:40294295
Clinical insights into circulating free-DNA in patients with bone sarcomas and ewing sarcoma., PMID:40288045
ATRX, OLIG2, MGMT, and IDH2 in Glioblastoma: Essential Molecular Mechanisms and Therapeutic Significance., PMID:40282990
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer., PMID:40274961
Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3., PMID:40256914
Protein Phosphatase 1 Regulatory Subunit 3C integrates cholesterol metabolism and isocitrate dehydrogenase in chondrocytes and neoplasia., PMID:40232792
Recent Developments in Differentiation Therapy of Acute Myeloid Leukemia., PMID:40227641
Gene Mutation Characteristics and Prognostic Significance in Acute Myeloid Leukemia Patients From Northeast China., PMID:40226311
Investigation of NPM1 mutation frequency in cutaneous blastic plasmacytoid dendritic cell neoplasms., PMID:40216030
LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke., PMID:40211238
Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated macrophage metabolism., PMID:40203081
SIRT5 alleviates oxidative stress of boar sperm induced by cryopreservation through IDH2 and SOD2 pathway., PMID:40198939
Isocitrate dehydrogenase 1 gene mutations: a case review unveiling its biological impact on disease progression, prognosis and treatment in Chilean patients., PMID:40182999
Genomic Characterization of Chondrosarcoma Reveals Potential Therapeutic Targets., PMID:40117529
Effect of NPM1 Mutation Subtype and Co-Mutation Patterns on the Outcomes of Acute Myeloid Leukemia., PMID:40103515
A retrospective study of outcomes across time and treatment regimens in newly diagnosed, FMS-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia., PMID:40097915
A genetically encoded fluorescent sensor enables sensitive and specific detection of IDH mutant associated oncometabolite D-2-hydroxyglutarate., PMID:40087637
GPR30-driven fatty acid oxidation targeted by ginsenoside Rd maintains mitochondrial redox homeostasis to restore vascular barrier in diabetic retinopathy., PMID:40087616
Multihit TP53 Mutations in Myeloproliferative Neoplasms and Acute Myeloid Leukemia: Comparative Analysis of Survival and Risk Factors in 142 Informative Cases., PMID:40079250
Outcome of Patients With IDH-Mutated AML Following Allogeneic Stem Cell Transplantation-A Retrospective Analysis on Behalf of the German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy, DRST., PMID:40058648
IGF2BP3 prefers to regulate alternative splicing of genes associated with the progression of gastric cancer in AGS cells., PMID:39998701
Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG., PMID:39975355
Chemical Proteomics Reveals Human Off-Targets of Fluoroquinolone Induced Mitochondrial Toxicity., PMID:39964703
Metabolism and therapeutic response in acute myeloid leukemia with IDH1/2 mutations., PMID:39955197
Higher mitochondrial protein-Succinylation detected in lung tissues of idiopathic pulmonary fibrosis patients., PMID:39938635
Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial., PMID:39917990
IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread., PMID:39899075
Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma., PMID:39880824
Infectious Spleen and Kidney Necrosis Virus ORF093R and ORF102R Regulate Glutamate Metabolic Reprogramming to Support Virus Proliferation by Interacting with c-Myc., PMID:39859431
Necroptosis-Related Gene Signature Predicts Prognosis in Patients with Advanced Ovarian Cancer., PMID:39858052
The roles of IDH2 and glutathione metabolism in cetuximab resistance in head and neck squamous cell carcinoma investigated by metabolomics and transcriptomics., PMID:39842530
Frank Invasion in Tall Cell Carcinoma With Reversed Polarity of the Breast: Report of Two Cases., PMID:39828059
Acute Myeloid Leukemia with Eosinophilia (FAB AML-M4Eo) having NPM1/DNMT3A/IDH2 Gene Mutations and t(5;12)(q31;p13)., PMID:39808159
Single-cell mapping of regulatory DNA:Protein interactions., PMID:39803441
The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome., PMID:39790063
SIRT5 desuccinylating IDH2 to alleviate oxidative stress in bovine mammary epithelial cells induced by ammonia., PMID:39788270
Follicular Helper T-cell Lymphoma With Hodgkin/Reed-Sternberg-Like Cells Versus Classic Hodgkin Lymphoma: A Comparative Study., PMID:39758028
The clinical features and outcomes of elderly patients with acute myeloid leukemia: a real word research., PMID:39751973
Safety profile of isocitrate dehydrogenase inhibitors in cancer therapy: a pharmacovigilance study of the FDA Adverse Event Reporting System., PMID:39727294
SENP1 promotes deacetylation of isocitrate dehydrogenase 2 to inhibit ferroptosis of breast cancer via enhancing SIRT3 stability., PMID:39690748
Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2., PMID:39689747
Non-Susceptibility Gene Variants in Head and Neck Paragangliomas., PMID:39684472
Acute myeloid leukemia treatment outcomes with isocitrate dehydrogenase mutations: A systematic review and meta-analysis., PMID:39654207
For research use only. Not for human or drug use.
