Catalog No.
DHJ63104
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG2-lambda
Clonality
Monoclonal
Target
SGRF, IL-23-A, IL-23 subunit alpha, Interleukin-23 subunit p19, IL23A, Interleukin-23 subunit alpha, IL-23p19
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NPF7
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
AMG-139, MEDI2070, CAS: 1610353-18-8
Clone ID
Brazikumab
A Noninvasive Method to Assess Mucosal Healing in Patients* With Crohn's Disease, PMID: 29991933
Anti-interleukin-12 and anti-interleukin-23 agents in Crohn's disease, PMID: 30571147
Anti-interleukin-23 agents for the treatment of ulcerative colitis, PMID: 31760827
Emerging Treatment Options in Inflammatory Bowel Disease: Janus Kinases, Stem Cells, and More, PMID: 32570252
Expert opinion on interleukin-12/23 and interleukin-23 antagonists as potential therapeutic options for the treatment of inflammatory bowel disease, PMID: 30884245
IL12/23 or selective IL23 inhibition for the management of moderate-to-severe Crohn's disease?, PMID: 31327402
Investigational drugs in phase I and phase II clinical trials targeting interleukin 23 (IL23) for the treatment of Crohn's disease, PMID: 30056776
Mini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis, PMID: 31447673
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?, PMID: 28765121
The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges, PMID: 34079536
Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease, PMID: 28838418
[Old and New Biologics and Small Molecules in Inflammatory Bowel Disease: Anti-interleukins]., PMID:39176462
The Role of IL-23 Inhibitors in Crohn's Disease., PMID:38202231
Long-term safety of brazikumab in the open-label period of a randomized phase 2a study of patients with Crohn's disease., PMID:38124112
Combining pharmacometric models with predictive and prognostic biomarkers for precision therapy in Crohn's disease: A case study of brazikumab., PMID:37691451
Promising phase II biologics for future Crohn's disease therapy., PMID:37249522
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease., PMID:37069321
Blockade of IL-23: What is in the Pipeline?, PMID:35553666
Personalised Medicine with IL-23 Blockers: Myth or Reality?, PMID:35553661
The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges., PMID:34079536
Emerging Treatment Options in Inflammatory Bowel Disease: Janus Kinases, Stem Cells, and More., PMID:32570252
Anti-interleukin-23 agents for the treatment of ulcerative colitis., PMID:31760827
Mini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis., PMID:31447673
IL12/23 or selective IL23 inhibition for the management of moderate-to-severe Crohn's disease?, PMID:31327402
Expert opinion on interleukin-12/23 and interleukin-23 antagonists as potential therapeutic options for the treatment of inflammatory bowel disease., PMID:30884245
Anti-interleukin-12 and anti-interleukin-23 agents in Crohn's disease., PMID:30571147
Investigational drugs in phase I and phase II clinical trials targeting interleukin 23 (IL23) for the treatment of Crohn's disease., PMID:30056776
A Noninvasive Method to Assess Mucosal Healing in Patients* With Crohn's Disease., PMID:29991933
Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease., PMID:28838418
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?, PMID:28765121
For research use only. Not for human or drug use.
