Catalog No.
YHE40301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala115-Met329
Predicted molecular weight
25.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43235
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cathepsin O, Cathepsin K, Cathepsin X, CTSO, Cathepsin O2, CTSK, CTSO2
Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction - PTHrP as a therapeutic target., PMID:40444046
An acid-responsive bone-targeting nanoplatform loaded with curcumin balances osteogenic and osteoclastic functions., PMID:40443874
β-Glucan modulates trained immunity to inhibit osteoclast differentiation via NOD2/RIPK2 signaling pathway., PMID:40424656
Polysaccharides from Psoralea corylifolia seeds suppress osteoclastogenesis and alleviate osteoporosis., PMID:40403806
NuanXin Formula inhibits bone resorption to combat osteoporosis by attenuating osteoclast oxidative phosphorylation., PMID:40398705
Myocyte-Specific Enhancer Factor 2A Potentiates Osteoclastic Differentiation in Osteoporosis by Inducing Endothelin Receptor Type A., PMID:40369222
Pycnodysostosis: a case series of eight Saudi patients with cathepsin K gene mutation and a literature review., PMID:40313484
Vertebral Osteoporosis in Systemic Lupus Erythematosus: A Possible Involvement of Inflammation-Related Osteoblast Ferroptosis., PMID:40303004
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis., PMID:40287031
Orthodontic treatment after occlusal intervention balances osteoblast and osteoclast differentiation via SIRT1 beta catenin signaling in rats with hypofunctional occlusion., PMID:40263606
Cathepsin K Inhibitors as Potential Drugs for the Treatment of Osteoarthritis., PMID:40243480
Sophoraflavanone G as an ectosteric inhibitor of cathepsin K attenuates ovariectomy-induced bone loss by suppressing bone resorption., PMID:40220429
Integrating thermal proteome profiling and virtual screening to reveal the mechanism of Bletilla striata against osteoclast-driven osteoporosis., PMID:40220420
The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins., PMID:40212812
Iguratimod modulates osteoclast differentiation in rheumatoid arthritis: Insights into AMPK/HIF-1α signaling pathway regulation., PMID:40203680
ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway., PMID:40197211
Targeted Dual Microdroplets for Modulating Osteoclast Differentiation and Function: A Novel Therapeutic Approach to Combat Osteoporosis., PMID:40181685
Norwogonin Attenuates Inflammatory Osteolysis and Collagen-Induced Arthritis via Modulating Redox Signalling and Calcium Oscillations., PMID:40099974
Arcyriaflavin A Alleviates Osteoporosis by Suppressing RANKL-Induced Osteoclastogenesis., PMID:40076762
Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway., PMID:40059399
[Effect and mechanism of acupotomy tendon-sparing and knot-dissolving technique in inhibiting bone destruction in rats with rheumatoid arthritis based on the PI3K/AKT/NFATc1 pathway]., PMID:40059046
Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis., PMID:40008134
Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork., PMID:39990379
"Betaone" barley water extract suppresses ovariectomy-induced osteoporosis in vivo and RANKL-induced osteoclast differentiation in vitro., PMID:39982961
Isonardosinone attenuates osteoclastogenesis and OVX-induced bone loss via the MAPK/NF-κB pathway., PMID:39956462
Casticin Inhibits Osteoclastogenesis via NF-κB/BCL-2 Signaling Pathway., PMID:39947684
The Sirt1/FOXO signal pathway involves in regulating osteomyelitis progression via modulating mitochondrial dysfunctions and osteogenic differentiation., PMID:39939446
Exacerbating effects of Western dietary habits on experimentally induced periodontitis in rats., PMID:39937328
Effect of Luteolin on cadmium-inhibited bone growth via suppressing osteoclastogenesis in laying chickens., PMID:39921628
Roles of B-cell lymphoma 6 in orthodontic tooth movement of rat molars., PMID:39917993
Sodium Danshensu alleviates bone cancer pain by inhibiting the osteoclast differentiation and CGRP expression., PMID:39900329
Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle., PMID:39878121
Molecular Profiling of Odontoclasts during Physiological Tooth Replacement., PMID:39876039
Chemerin mediates exercise-induced improvements of bone microstructure and bone mass in diabetes or high fat diet mice., PMID:39864488
[Effect of osteon-like concentric microgroove structures of different sizes on the osteoclastic differentiation of macrophages]., PMID:39848804
Gossypin Ameliorates Collagen-Induced Arthritic Rats by Inhibiting Angiogenesis, Inflammation and Oxidative Stress., PMID:39838839
Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification., PMID:39833160
[Mechanism of Colquhounia Root Tablets in inhibiting osteoclast differentiation based on HSP90 target modulation]., PMID:39805785
Conditional Deletion of Gremlin-1 in Cathepsin K-expressing Mature Osteoclasts Altered the Skeletal Response to Calcium Depletion in Sex-Dependent Manner., PMID:39789342
[MED15-TFE3 renal cell carcinoma: a clinicopathological and molecular analysis]., PMID:39762166
Alendronate partially rescues the periodontal defects in OIM mouse model of osteogenesis imperfecta., PMID:39747677
Modified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway., PMID:39741920
Suppression of Bone Formation and Resorption by the Deletion of Complex Gangliosides., PMID:39740874
Transcriptomic integration and ligand-receptor crosstalk reveal the underlying molecular mechanisms between hip cartilage and subchondral bone in osteonecrosis of femoral head., PMID:39708930
Case Report: A Novel Homozygous Variant of the CTSK Gene in Rare Pycnodysostosis., PMID:39684735
Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure., PMID:39616671
Development and characterization of an in vitro fluorescently tagged 3D bone-cartilage interface model., PMID:39600948
The diagnostic value investigation of programmed cell death genes in heart failure., PMID:39574022
A NOTCH2 pathogenic variant and HES1 regulate osteoclastogenesis in induced pluripotent stem cells., PMID:39571704
Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts., PMID:39569657
For research use only. Not for human or drug use.
