Catalog No.
YHE37201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln45-Leu184
Predicted molecular weight
18.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42702
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LIFR, LIF-R, CD118, LIF receptor, Leukemia inhibitory factor receptor
Stüve-Wiedemann syndrome with a novel variant in the LIFR gene: A case report., PMID:39889153
Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome., PMID:39847438
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis., PMID:39636853
hsa_circ_0072309 Inhibits Oncogenesis in Hepatocellular Carcinoma by Epigenetic Activation of its Host Gene., PMID:39283585
Roles of leukemia inhibitory factor receptor in cancer., PMID:39279155
Super-Enhancer Driven LIF/LIFR-STAT3-SOX2 Regulatory Feedback Loop Promotes Cancer Stemness in Head and Neck Squamous Cell Carcinoma., PMID:39206755
Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification., PMID:39084258
Mutations in LIFR rewire the JAK/STAT signaling pathway: A study unveiling mechanistic details of Stüve-Wiedemann syndrome., PMID:38968765
Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis., PMID:38914806
COL5A2 drives regorafenib resistance-induced metastatic phenotype via reducing LIFR expression in hepatocellular carcinoma., PMID:38818582
Regulatory role of miR-125a expression with respect to its target genes LIFR, ERBB2 and STAT3 in the pathogenesis of recurrent pregnancy losses., PMID:38528801
Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis., PMID:38494064
PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR., PMID:38409028
Immunosuppressive role of BDNF in therapy-induced neuroendocrine prostate cancer., PMID:38381121
The LIFR Inhibitor EC359 Effectively Targets Type II Endometrial Cancer by Blocking LIF/LIFR Oncogenic Signaling., PMID:38139260
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer., PMID:37945798
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness., PMID:37927213
BMPRII+ neural precursor cells isolated and characterized from organotypic neurospheres: an in vitro model of human fetal spinal cord development., PMID:37488910
Role and mechanism of leukemia inhibitory factor receptor in cervical cancer invasion and metastasis., PMID:37357760
Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes., PMID:37061565
Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux., PMID:36417404
Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer., PMID:36316703
CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression., PMID:36104590
Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice., PMID:35950514
LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma., PMID:35778954
The Pleiotropic role, functions and targeted therapies of LIF/LIFR axis in cancer: Old spectacles with new insights., PMID:35680099
Altered expression of leukemia inhibitory factor (LIF), LIFR, gp130, and IL11 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome., PMID:35306361
The ILEI/LIFR complex induces EMT via the Akt and ERK pathways in renal interstitial fibrosis., PMID:35093095
Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers., PMID:35071590
Circ_0003159 upregulates LIFR expression through competitively binding to miR-221-3p/miR-222-3p to block gastric cancer development., PMID:35034206
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis., PMID:34921145
Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells., PMID:34803492
Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis., PMID:34781815
LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer., PMID:34716410
miR-221-3p regulates hepatocellular carcinoma cell proliferation, migration and invasion via targeting LIFR., PMID:34699986
M6A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling., PMID:34658294
HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer., PMID:34247191
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma., PMID:34087162
Lidocaine Suppresses Gastric Cancer Development Through Circ_ANO5/miR-21-5p/LIFR Axis., PMID:34050852
Association of novel stop-gained leukaemia inhibitory factor receptor gene (rs121912501) variant, leukaemia inhibitory factor and ovarian steroids with unexplained infertility among Pakistani women., PMID:33914392
An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy., PMID:33846527
Cross-reactivity of two human IL-6 family cytokines OSM and LIF explored by protein-protein docking and molecular dynamics simulation., PMID:33845142
Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression., PMID:33475233
Delineation of the clinical and radiological features of Stuve-Wiedemann syndrome childhood survivors, four new cases and review of the literature., PMID:33305909
STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis., PMID:33262462
Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-κB pathway in glioma., PMID:33070767
EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer., PMID:32963351
Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway., PMID:32827446
Novel Long Non-coding RNA lncAMPC Promotes Metastasis and Immunosuppression in Prostate Cancer by Stimulating LIF/LIFR Expression., PMID:32592689
Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand., PMID:32522868
For research use only. Not for human or drug use.
