Catalog No.
YRE34401
Expression system
E. coli
Species
Rattus norvegicus (Rat)
Protein length
Gly557-Trp841
Predicted molecular weight
33.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q1KQ07
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-4 Stat, STAT6, Signal transducer and activator of transcription 6
Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer., PMID:40514067
IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma., PMID:40500109
Eosinophil-derived neurotoxin and eosinophil cationic protein are key molecules for blister formation in bullous pemphigoid., PMID:40488683
FCGR2A contributes to M2 macrophages polarization in HCC through IL-4/JAK/STAT6 axis., PMID:40482466
Evaluation of T-cell Function after Blood Transfusion in Patients Undergoing Coronary Artery Bypass Grafting., PMID:40471640
Anti-tumor and immunomodulation activity of polysaccharide from Paris polyphylla Smith var. chinensis in S180 tumor-bearing mice., PMID:40457538
Single-cell sequencing reveals shared clonal signatures in nonmalignant B and tumor cells in T-prolymphocytic leukemia., PMID:40453149
Modulating the renin-angiotensin system by eprosartan or xanthenone drives microglial M2 polarization in a rat model of Parkinson's disease via regulating the interplay between MKP-1/ miR-155 /SOCS1 and PP2A signaling network., PMID:40440958
Dedifferentiated Solitary Fibrous Tumor: A Clinicopathologic, Immunohistochemical, and Molecular Characterization of 25 Cases., PMID:40420616
Relaxin-2 Ameliorates Spinal Cord Injury by Inhibiting Microglia Activation., PMID:40392018
Cannabinoid WIN55,212-2 restores bronchial epithelium by regulating oxidative stress and STAT6 phosphorylation., PMID:40383489
Association of STAT6 gene polymorphism with atopic asthma among Yemeni children in Sana'a city, Yemen., PMID:40375219
Malonate promotes CD8+ T cell memory formation via protein malonylation., PMID:40369188
[Experimental study on Jianpi Qutan Formula regulating M1/M2 macrophage polarization to improve atherosclerosis]., PMID:40350948
SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma., PMID:40349036
AXL promotes inflammatory breast cancer progression by regulating immunosuppressive macrophage polarization., PMID:40329335
CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD., PMID:40311344
Melittin Inhibits Ovarian Cancer Cell Growth by Downregulating MMP9 Expression via the JAK2-STAT3 Signaling Pathway., PMID:40304331
Functional Attributes of Synovial Fluid from Osteoarthritic Knee Exacerbate Cellular Inflammation and Metabolic Stress, and Fosters Monocyte to Macrophage Differentiation., PMID:40299511
Berberine Suppression of Human IgE but Not IgG Production via Inhibition of STAT6 Binding Activity at IgE Promoter by BCL6., PMID:40277916
Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasis., PMID:40276761
Vitamin D deficiency promotes intervertebral disc degeneration via p38/NCoR2-mediated extracellular matrix degradation., PMID:40274653
SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis., PMID:40250791
The transcription factor BMAL1 inhibits endothelial cell apoptosis by targeting STAT6 to repress its expression., PMID:40246133
IL-17 enhanced the susceptibility to fluoxetine resistance in depression via the JAK1-STAT6 signaling pathway., PMID:40233450
MiR-135a-5p/STAT6-mediated EMT regulates IL-4 secretion in non-small cell lung cancer to affect M2-like TAM polarization., PMID:40199139
Preadipocyte IL-13/IL-13Rα1 signaling regulates beige adipogenesis through modulation of PPARγ activity., PMID:40198135
Modulation of pulmonary immune functions by the Pseudomonas aeruginosa secondary metabolite pyocyanin., PMID:40196115
PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy., PMID:40187753
Cathepsin B promotes optic nerve axonal regeneration., PMID:40177832
[PRRX1-rearranged fibroblastic tumor: a clinicopathological and molecular analysis of four cases]., PMID:40159029
[miR-373 inhibits M2 polarization of tumor associated macrophages and affects rectal cancer cells by regulating JAK2/STAT6 signal pathway]., PMID:40145452
Alveolar epithelial type 2 cell specific loss of IGFBP2 activates inflammation in COVID-19., PMID:40121473
[Evolution of grading for solitary fibrous tumors of the central nervous system: a clinical pathological and prognostic analysis]., PMID:40113429
SIRPα modulates microglial efferocytosis and neuroinflammation following experimental subarachnoid hemorrhage via the SHP1/STAT6 axis., PMID:40108663
Tumor Cell-Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer., PMID:40105652
LKB1 activated by NaB inhibits the IL-4/STAT6 axis and ameliorates renal fibrosis through the suppression of M2 macrophage polarization., PMID:40097066
The RNA-binding protein KSRP reduces asthma-like characteristics in a murine model., PMID:40095032
IL-33-Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1-IGF2R Axis in Ankylosing Spondylitis., PMID:40091508
Dexmedetomidine modulates peritoneal macrophage to attenuate lipopolysaccharide-induced inflammation., PMID:40088848
Naoqing formula alleviates cerebral ischemia/reperfusion injury induced inflammatory injury by regulating Csf3 mediated JAK/STAT pathway and macrophage polarization., PMID:40088744
Macrophage-mediated activation of the IL4I1/AhR axis is a key player in allergic rhinitis., PMID:40080924
Myeloid-derived IL-33 drives γδ T cell-dependent resistance against cutaneous infection by Strongyloides ratti., PMID:40073150
DDR2 alleviates retinal vaso-obliteration and pathological neovascularization by modulating microglia M1/M2 phenotypic polarization in a mouse model of proliferative retinopathy., PMID:40064060
Spermidine Inhibits M1 Microglia Polarization in a Mouse Model of Parkinson's Disease and BV2 Cells via NF-κB/STAT-1 Pathway., PMID:40059454
RPS24 haploinsufficiency impairs erythropoiesis in the Diamond-Blackfan anemia zebrafish model via the STAT6-SATB1 pathway., PMID:40054062
Lingganwuweijiangxin Decoction suppresses allergic airway inflammation in Guinea pigs with cough variant asthma by regulating the treg/Th17 balance and the JAK1/STAT6 signaling pathway., PMID:40051262
Panax notoginseng saponins ameliorate LPS-induced acute lung injury by promoting STAT6-mediated M2-like macrophage polarization., PMID:40010033
Placental malaria infection is associated with downregulation of STAT-6 and ANG-1 in decidual macrophages., PMID:40007543
Sinonasal EWSR1::POU2AF3 sarcoma: a case report and literature review., PMID:39982522
For research use only. Not for human or drug use.
