Catalog No.
YHE32601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu455-Gln591
Predicted molecular weight
16.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P41440
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Intestinal folate carrier 1, FOLT, Solute carrier family 19 member 1, RFC1, hSLC19A1, IFC-1, SLC19A1, RFT-1, FLOT1, RFC, Placental folate transporter, Reduced folate transporter 1, Reduced folate transporter, Reduced folate carrier protein, hRFC
Folate transfer in placental choriocarcinoma cells treated with valproic acid: Insights gained through comparisons with the amide derivative sec-butylpropylacetamide and its individual stereoisomers., PMID:40464080
Low Dose Methotrexate Has Divergent Effects on Cycling and Resting Human Hematopoietic Stem and Progenitor Cells., PMID:40289289
Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport., PMID:40175380
Analysis of the Association Between the SLC19A1 Genetic Variant (rs1051266) and Autism Spectrum Disorders, Cerebral Folate Deficiency, and Clinical and Laboratory Parameters., PMID:40156756
Development and Characterization of Curcumin Loaded PEGylated Niosomal Nanoparticles: Potential Anti-Cancer Effect on Breast Cancer Cells through RFC Gene Expression., PMID:40156420
SLC19A1 Gene Polymorphism; Risk Factor for Preeclampsia., PMID:40055164
Effects of SCT genetic polymorphisms on methotrexate concentrations and toxicities in Chinese children with acute lymphoblastic leukemia., PMID:39798147
Association of Reduced Folate Carrier G80A Polymorphism With Lung Cancer Susceptibility in a Hypertensive Population: A Nested Case-Control Study., PMID:39740751
Herpes simplex virus-1 targets the 2'-3'cGAMP importer SLC19A1 as an antiviral countermeasure., PMID:39637474
Rapamycin-loaded nanostructured lipid carrier modified with folic acid intended for breast cancer therapy., PMID:39542123
Frequency of pharmacogenomic variants affecting safety and efficacy of immunomodulators and biologics in a South Asian population from Sri Lanka., PMID:39334333
Functional Characterization of Reduced Folate Carrier and Protein-Coupled Folate Transporter for Antifolates Accumulation in Non-Small Cell Lung Cancer Cells., PMID:39261014
Alteration in folate carrier expression via histone deacetylase inhibition in BeWo human placental choriocarcinoma cells., PMID:39237058
A Homozygous Variant in NAA60 Is Associated with Primary Familial Brain Calcification., PMID:39229657
Regulation of folate transport at the mouse arachnoid barrier., PMID:39192328
Import of extracellular 2'-3'cGAMP by the folate transporter, SLC19A1, establishes an antiviral response that limits herpes simplex virus-1., PMID:39154753
Transcriptome Analysis of Hypothalamic-Pituitary-Ovarian Axis Reveals circRNAs Related to Egg Production of Bian Chicken., PMID:39123779
Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles., PMID:39062651
Antiretroviral drug dolutegravir induces inflammation at the mouse brain barriers., PMID:38982638
Evaluation of transport mechanisms of methotrexate in human choriocarcinoma cell lines by LC-MS/MS., PMID:38823222
Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC., PMID:38669181
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels., PMID:38652659
Enhancing the anticancer effect of androgen deprivation therapy by monocarboxylate transporter 1 inhibitor in prostate cancer cells., PMID:38558458
Altered placental immune cell composition and gene expression with isolated fetal spina bifida., PMID:38528656
Increased susceptibility for nonsyndromic cleft lip with or without cleft palate by SLC19A1 80G>A genetic variation., PMID:38395727
GENETIC PREDICTORS OF TOXIC EFFECTS OF METHOTREXATE IN CANCER PATIENTS., PMID:38328850
Vitamin D promotes the folate transport and metabolism in zebrafish (Danio rerio)., PMID:38324257
Low-dose daily folic acid (400 μg) supplementation does not affect regulation of folate transporters found present throughout the terminal ileum and colon of humans: a randomized clinical trial., PMID:38157986
Efficient delivery of methotrexate to MDA-MB-231 breast cancer cells by a pH-responsive ZnO nanocarrier., PMID:38081993
Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines., PMID:38074116
Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele., PMID:37883728
Effects of folate deficiency and sex on carcinogenesis in a mouse model of oral cancer., PMID:37731277
Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide polymorphisms: a prospective observational study., PMID:37633908
How Cryo-EM Has Expanded Our Understanding of Membrane Transporters., PMID:37438132
Genomic Landscape of Copy Number Variations and Their Associations with Climatic Variables in the World's Sheep., PMID:37372436
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity., PMID:37328777
Gender-specific association of SLC19A1 and MTHFR genetic polymorphism with oxidative stress biomarkers and plasma folate levels in older adults., PMID:37201763
Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS-STING immune pathway., PMID:37147228
Correlation between methylation level of the SLC19A1 promoter region and methotrexate metabolism in adult acute lymphoblastic leukemia., PMID:36999405
Pharmacogenetics of the Primary and Metastatic Osteosarcoma: Gene Expression Profile Associated with Outcome., PMID:36982681
Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia., PMID:36764694
Novel immunodeficiency caused by homozygous mutation in solute carrier family 19 member 1, which encodes the reduced folate carrier., PMID:36745868
Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment., PMID:36517554
Testicular Hypoplasia with Normal Fertility in Neudesin-Knockout Mice., PMID:36450531
Novel localization of folate transport systems in the murine central nervous system., PMID:36419095
Recognition of cyclic dinucleotides and folates by human SLC19A1., PMID:36265513
Methotrexate recognition by the human reduced folate carrier SLC19A1., PMID:36071163
Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas., PMID:36056753
Hypoxia-Immune-Related Gene SLC19A1 Serves as a Potential Biomarker for Prognosis in Multiple Myeloma., PMID:35958555
SLC19A1 Genetic Variation Leads to Altered Thiamine Diphosphate Transport: Implications for the Risk of Developing Wernicke-Korsakoff's Syndrome., PMID:35952336
For research use only. Not for human or drug use.
