Catalog No.
YHE29901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr408
Predicted molecular weight
47.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P41182
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BCL-5, BCL-6, Protein LAZ-3, ZNF51, BCL6, ZBTB27, Zinc finger protein 51, B-cell lymphoma 6 protein, Zinc finger and BTB domain-containing protein 27, B-cell lymphoma 5 protein, BCL5, LAZ3
Inhibitior of Bcl6 by FX1 protects DSS induced colitis mice through anti-inflammatory effects., PMID:40416976
BCL-6-Positive Cutaneous Mantle Zone Hyperplasia: A Novel Subtype of B-Cell Cutaneous Lymphoid Hyperplasia., PMID:40321030
Berberine Suppression of Human IgE but Not IgG Production via Inhibition of STAT6 Binding Activity at IgE Promoter by BCL6., PMID:40277916
Designed peptide binders and nanobodies as PROTAC starting points for targeted degradation of PCNA and BCL6., PMID:40164264
Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6/Blimp-1 pathway., PMID:40021065
TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R-BCL6 signaling nexus., PMID:39951546
Small molecule BCL6-inhibition suppresses follicular T helper cell differentiation and plasma blast formation., PMID:39903994
BCL6 (B-cell lymphoma 6) expression in adenomyosis, leiomyomas and normal myometrium., PMID:39903727
Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma., PMID:39885128
Detecting B-cell lymphoma-6 overexpression status in primary central nervous system lymphoma using multiparametric MRI-based machine learning., PMID:39853344
BCL6 coordinates muscle mass homeostasis with nutritional states., PMID:39841144
[Patient with diffuse large B-cell lymphoma: a good example of network in care]., PMID:39840882
Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth., PMID:39815148
Diffuse Large B-Cell Lymphoma/High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements: A Study of 60 Cases., PMID:39805522
BCL6 Alleviates Hepatic Ischemia/Reperfusion Injury Via Recruiting SIRT1 to Repress the NF-κB/NLRP3 Pathway., PMID:39800885
Exploration of Key Regulatory Factors in Mesenchymal Stem Cell Continuous Osteogenic Differentiation via Transcriptomic Analysis., PMID:39766835
Zanubrutinib plus R-CHOP for the treatment of newly diagnosed double-expressor lymphoma: A phase 2 clinical study., PMID:39748728
Aberrant bcl6 protein expression in patients with EMZL following recurrence or progression: case report of two cases., PMID:39726003
BCL6 Promotes Transcription of GPR61 to Suppress IL-1β-Induced Osteoarthritis Progression in C28/I2 Cells., PMID:39716366
How I diagnose high-grade B-cell lymphoma., PMID:39689165
MRI-based radiomics virtual biopsy for BCL6 in primary central nervous system lymphoma., PMID:39615185
High-grade B-cell lymphomas: Double hit and non-double hit., PMID:39603365
Mechanism of PD-1/PD-L1 in Regulating cTfr/cTfh Balance in Patients with Rheumatoid Arthritis., PMID:39586747
Type 1 Diabetes Depends on CD4-Driven Expression of the Transcriptional Repressor Bcl6., PMID:39556799
Comparative investigation among fluorescence in situ hybridization, DNA- and RNA-sequencing on detecting MYC, BCL2, and BCL6 rearrangements in high-grade B-cell lymphomas., PMID:39556426
Localized large B-cell lymphoma with MYC and BCL6 rearrangements as an unexpected finding in an appendectomy specimen., PMID:39500731
B Cell Lymphoma 6 (BCL6): A Conserved Regulator of Immunity and Beyond., PMID:39456751
The high-grade B-cell lymphomas: double hit and more., PMID:39427343
A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment., PMID:39419175
Limited stage high grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: BCL2 rearrangements drives the poor outcomes., PMID:39402034
Spatial microniches of IL-2 combine with IL-10 to drive lung migratory TH2 cells in response to inhaled allergen., PMID:39394532
A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma., PMID:39387112
Relocalizing transcriptional kinases to activate apoptosis., PMID:39361741
Double-hit primary central nervous system lymphoma with histogenetically proven bone marrow infiltration: a case report and a review of the literature., PMID:39215902
Discovery of novel BCL6-Targeting PROTACs with effective antitumor activities against DLBCL in vitro and in vivo., PMID:39208743
[A consistency comparison between next-generation sequencing and the FISH method for gene rearrangement detection in B-cell lymphomas]., PMID:39134487
BCL6 confers resistance to HDAC inhibitors in DLBCL., PMID:39102989
[Interim efficacy of a multicenter cohort study for China Net Childhood Lymphoma mature B-cell lymphoma 2017 regimen in the treatment of pediatric High-grade-B cell lymphoma]., PMID:39075995
The transcriptional repressor B cell lymphoma 6 regulates CXCR3 chemokine and human leukocyte antigen II expression in endothelial cells., PMID:39074669
Heterogeneity or change in cell of origin in diffuse large B-cell lymphomas determined using hans algorithm., PMID:39069202
Key Functions of the Transcription Factor BCL6 During T-Cell Differentiation., PMID:39017840
BCL6 overexpression in CD4+ T cells induces Tfh-like transdifferentiation and enhances antitumor efficiency of CAR-T therapy in pancreatic cancer., PMID:38986820
Comparison of serum levels of IL-10 and IL-11 and mRNA expression of IL-10, IL-11, COX-2, BCL6, and ZEB Family in peripheral blood mononuclear cells (PBMC) of women with polycystic ovary syndrome and healthy individuals., PMID:38941927
Characteristics and Clinical Value of MYC , BCL2, and BCL6 Rearrangement Detected by Next-generation Sequencing in DLBCL., PMID:38937822
Molecular characterization of a rare case of high-grade B-cell lymphoma with MYC, BCL2, BCL6, and CCND1 rearrangements., PMID:38914869
Expression and Clinical Significance of Ki-67, CD10, BCL6, MUM1, c-MYC, and EBV in Diffuse Large B Cell Lymphoma Patients., PMID:38872345
The F-box E3 ligase protein FBXO11 regulates EBNA3C-associated degradation of BCL6., PMID:38864622
[Diagnosis and differential diagnosis of large B-cell lymphoma with IRF4 rearrangement]., PMID:38825901
A new mode for the diagnosis of angioimmunoblastic T-cell lymphoma., PMID:38814221
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation., PMID:38761804
For research use only. Not for human or drug use.
