Catalog No.
YHE26401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg258
Predicted molecular weight
31.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P40261
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nicotinamide N-methyltransferase, NNMT
Nicotinamide N-Methyltransferase (NNMT) and Liver Cancer: From Metabolic Networks to Therapeutic Targets., PMID:40427612
NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis., PMID:40404636
Preliminary investigation of nicotinamide N-methyltransferase as an HBV-specific biomarker for hepatocellular carcinoma diagnosis., PMID:40329575
Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves' Orbitopathy., PMID:40310625
1,4-Dioxane Induces Epithelial-Mesenchymal Transition and Carcinogenesis in an Nrf2-Dependent Manner., PMID:40304624
Downregulation of NNMT affects trophoblast function via inhibiting COMP/CD36/ERK1/2 axis in recurrent spontaneous abortion., PMID:40274084
Nicotinamide N-methyltransferase as a potential therapeutic target for neurodegenerative disorders: Mechanisms, challenges, and future directions., PMID:40221009
Mechanism and kinetics of turnover inhibitors of nicotinamide N-methyl transferase in vitro and in vivo., PMID:40209950
Increased Sirtuin 6 Activity in Tumor Cells Can Prompt CD4-Positive T-Cell Differentiation Into Regulatory T Cells and Impede Immune Surveillance in the Microenvironment., PMID:40162112
Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells., PMID:40116940
NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer., PMID:40089784
The complex role of glycine N-methyltransferase in metabolism-a review., PMID:40025311
NNMT is involved in deoxynivalenol-induced hepatocyte toxicity via promoting ferroptosis., PMID:39983889
N 1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1., PMID:39959464
Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer., PMID:39939075
PRDX6 Prevents NNMT Ubiquitination and Degradation as a Nonenzymatic Mechanism to Promote Ovarian Cancer Progression., PMID:39887931
Increasing cellular NAD+ protects hepatocytes against palmitate-induced lipotoxicity by preventing PARP-1 inhibition and the mTORC1-p300 pathway activation., PMID:39871470
Nicotinamide n-methyltransferase inhibitor synergizes with sodium-glucose cotransporter 2 inhibitor to protect renal tubular epithelium in experimental models of type 2 diabetes mellitus., PMID:39848127
Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis., PMID:39807704
NNMT suppresses H3K9me3 to facilitate malignant progression and drug resistance in gastric cancer., PMID:39757078
m6A demethylation of NNMT in CAFs promotes gastric cancer progression by enhancing macrophage M2 polarization., PMID:39725153
PI(4,5)P2 alleviates colitis by inhibiting intestinal epithelial cell pyroptosis through NNMT-mediated RBP4 m6A modification., PMID:39706833
Genetic inhibition of nicotinamide N-methyltransferase and prevention of alcohol-associated fatty liver in humans., PMID:39695269
Nicotinamide N-methyltransferase negatively regulates metastasis-promoting property of cancer-associated fibroblasts in lung adenocarcinoma., PMID:39623600
Exploring NNMT: from metabolic pathways to therapeutic targets., PMID:39604638
Overexpressed nicotinamide N‑methyltransferase in endometrial stromal cells induced by macrophages and estradiol contributes to cell proliferation in endometriosis., PMID:39489776
Downregulation of ferroptosis-related ATF3 alleviates lupus nephritis progression., PMID:39427833
Nicotinamide N-methyltransferase (NNMT): A key enzyme in cancer metabolism and therapeutic target., PMID:39312861
NNMT overexpression is an adverse prognostic factor in uterine leiomyosarcoma., PMID:39295619
Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia-reperfusion injury and remodels sphingosine metabolism., PMID:39168882
Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction., PMID:39161060
Identifying polyamine related biomarkers in diagnosis and treatment of ulcerative colitis by integrating bulk and single-cell sequencing data., PMID:39103474
NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis., PMID:39069579
NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer., PMID:39067875
Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy., PMID:39035994
Circadian Rhythm Disruption in Hepatocellular Carcinoma Investigated by Integrated Analysis of Bulk and Single-Cell RNA Sequencing Data., PMID:38891936
Nicotinamide N-Methyltransferase (NNMT) is Involved in Gastric Adenocarcinoma Immune Infiltration by Driving Amino Acid Metabolism., PMID:38855943
Fibroblast regulates angiogenesis in assembled oral cancer organoid: A possible role of NNMT., PMID:38566601
The dual GCGR/GLP-1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selection., PMID:38560764
Gastric Cancer in the Era of Epigenetics., PMID:38542354
Gastric Cancer With the Increased Nicotinamide N-methyltransferase-positive Stromal Cells Includes Unfavorable Prognosis-related Cancer-associated Fibroblasts., PMID:38537979
Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis., PMID:38412094
Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction., PMID:38264909
Effects of nano freezing-thawing on myofibrillar protein of Atlantic salmon fillets: Protein structure and label-free proteomics., PMID:38232615
Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis., PMID:38218787
Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function., PMID:38212381
Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity., PMID:38181447
NNMT/1-MNA Promote Cell-Cycle Progression of Breast Cancer by Targeting UBC12/Cullin-1-Mediated Degradation of P27 Proteins., PMID:38126621
Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease., PMID:37953778
Beyond the Rhythm: In Silico Identification of Key Genes and Therapeutic Targets in Atrial Fibrillation., PMID:37893006
For research use only. Not for human or drug use.
