Catalog No.
YHE25401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln17-Pro242
Predicted molecular weight
27.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P40197
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Platelet glycoprotein V, CD42d, GP5, GPV, Glycoprotein 5
Dynamics of a von Willebrand Factor A1 Autoinhibitory Module with O-Linked Glycans and Its Roles in Regulation of GPIbα Binding., PMID:40183925
CD19 chimeric antigen receptor-T cell therapy in murine immune thrombocytopenia., PMID:40139759
Association of glycoprotein 1b and miR-26a-5p levels with platelet function in Alzheimer's disease., PMID:40112326
Preventative and therapeutic effects of a novel humanized anti-glycoprotein Ibα fragment of antigen-binding region in a murine model of thrombotic thrombocytopenic purpura., PMID:39956431
A novel antibody against GPIbα inhibits platelet function and thrombosis without increasing bleeding., PMID:39924011
Structure-resolved dynamics of type 2M von Willebrand disease., PMID:39756657
Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation., PMID:39738271
Like Father, Like Daughter: A Family With a Constitutional Thrombocytopenia Variant Due to a Novel Heterozygous Missense Mutation in GP1BA., PMID:39737636
The role of protein kinase C and the glycoprotein Ibα cytoplasmic tail in anti-glycoprotein Ibα antibody-induced platelet apoptosis and thrombocytopenia., PMID:39541612
Platelet Glycoprotein Ibα Cytoplasmic Tail Exacerbates Thrombosis During Bacterial Sepsis., PMID:39519103
Platelet collagen receptors and their role in modulating platelet adhesion patterns and activation on alternatively processed collagen substrates., PMID:39499978
Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging., PMID:39433750
The effects of complement-independent, autoantibody-induced apoptosis of platelets in immune thrombocytopenia (ITP)., PMID:39271523
Platelet changes and bleeding symptoms in children, adolescents, and adults with 22q11.2 deletion syndrome., PMID:39228058
Bernard-Soulier Syndrome: A Review of Epidemiology, Molecular Pathology, Clinical Features, Laboratory Diagnosis, and Therapeutic Management., PMID:39191409
Platelet-Type von Willebrand Disease: Complex Pathophysiology and Insights on Novel Therapeutic and Diagnostic Strategies., PMID:39191406
Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy., PMID:39147240
[Rare VPS33B gene mutation combined with GP1BA mutation causes severe decrease in plasma VWF levels: a case report and literature review]., PMID:39134495
Western Diet Modifies Platelet Activation Profiles in Male Mice., PMID:39125586
Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets., PMID:39088777
Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα., PMID:39072582
New insights of glycoprotein Ib-IX-V complex organization and glycoprotein Ibα in platelet biogenesis., PMID:39046849
How unique structural adaptations support and coordinate the complex function of von Willebrand factor., PMID:38968155
High Levels of Triggering Receptor Expressed in Myeloid Cells-Like Transcript-1 Positive, but Not Glycoprotein 1b+, Microparticles Are Associated With Poor Outcomes in Acute Respiratory Distress Syndrome., PMID:38935146
A new platelet alloantigen (Efs2a) on glycoprotein GPIIIa leading to neonatal alloimmune thrombocytopenia., PMID:38924565
The compound pathogenic effects of a homozygous frameshift variant in the transmembrane region of GP9, causing Bernard-Soulier syndrome, with a missense variant in GP1BB., PMID:38923496
Reduction of ristocetin-induced platelet aggregation (RIPA) during storage despite plasma renewal: evidence for hemostatic importance of GPIbα shedding., PMID:38889268
Exploring ligands that target von Willebrand factor selectively under oxidizing conditions through docking and molecular dynamics simulations., PMID:38829206
Linking Computational Fluid Dynamics Modeling to Device-Induced Platelet Defects in Mechanically Assisted Circulation., PMID:38768482
Extracorporeal membrane oxygenation aggravates platelet glycoprotein V shedding and δ-granule deficiency in COVID-19-associated acute respiratory distress syndrome., PMID:38763215
Membrane Tilt Drives Phase Separation of Adhesion Receptors., PMID:38759206
Binding Mechanism between Platelet Glycoprotein and Cyclic Peptide Elucidated by McMD-Based Dynamic Docking., PMID:38751042
Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome., PMID:38750089
Shedding light on GPIbα shedding., PMID:38728102
Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size., PMID:38704122
Essential role of glycoprotein Ibα in platelet activation., PMID:38701351
WY-14643, a novel antiplatelet and antithrombotic agent targeting the GPIbα receptor., PMID:38669962
Differential Impact In Vivo of Pf4-ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice., PMID:38660804
Bernard-Soulier syndrome caused by a novel GP1BB variant and 22q11.2 deletion., PMID:38625506
Inflammasome-Independent Mechanism of NLRP3 is Critical for Platelet GPIb-IX Function and Thrombosis., PMID:38325399
GPIbα CAAR T cells function like a Trojan horse to eliminate autoreactive B cells to treat immune thrombocytopenia., PMID:38299614
Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases., PMID:38299390
Conformational transitions and activation of the adhesion receptor CD97., PMID:38215752
Recombinantly Expressed Tagged SUrface Protein (RETSUP) assay: a new diagnostic system for the detection of antibodies to platelets., PMID:38184205
Antiplatelet Agents Inhibit Platelet Adhesion and Aggregation on Glass Surface Under Physiological Flow Conditions: Toward a Microfluidic Platelet Functional Assay Without Additional Adhesion Protein Modification., PMID:38032897
In vitro field study and worldwide survey assessing how clinical haemostasis laboratories analyse recombinant and plasma-derived von Willebrand factor products., PMID:37926687
GPIbα-filamin A interaction regulates megakaryocyte localization and budding during platelet biogenesis., PMID:37922495
[Molecular dynamics simulation of force-regulated interaction between glycoprotein Ib α and filamin]., PMID:37879916
Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients., PMID:37722393
Wedging the door open on platelet-type von Willebrand disease., PMID:37666663
For research use only. Not for human or drug use.
