Catalog No.
YHE19301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser24-Glu126
Predicted molecular weight
13.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36896
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Activin receptor-like kinase 4, SKR2, ACVRLK4, ACVR1B, ALK-4, Activin receptor type IB, Activin receptor type-1B, Serine/threonine-protein kinase receptor R2, ACTR-IB, ALK4
Production of platelets in vitro in functionalised 3-dimensional scaffolds mimicking the bone marrow niche., PMID:40270202
Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder., PMID:40144023
Cripto-1 acts as a molecular bridge linking nodal to ALK4 via distinct structural domains., PMID:39840816
Reduced myotube diameter induced by combined inhibition of transforming growth factor-β type I receptors Acvr1b and Tgfbr1 is associated with enhanced β1-syntrophin expression., PMID:39164996
Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions From Acinar and Ductal Cells of Origin., PMID:39111635
Neutrophil-derived Activin-A moderates their pro-NETotic activity and attenuates collateral tissue damage caused by Influenza A virus infection., PMID:38476229
Transcriptomic evaluation of skin tape-strips in children with allergic asthma uncovers epidermal barrier dysfunction and asthma-associated biomarkers abnormalities., PMID:38375886
Validation of new immune and inflammation-related diagnostic biomarkers for RA., PMID:38285375
Potential Roles of Activin in Head and Neck Squamous Cell Carcinoma Progression and Mortality., PMID:38030164
Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial., PMID:37963137
Dual scaffold delivery of miR-210 mimic and miR-16 inhibitor enhances angiogenesis and osteogenesis to accelerate bone healing., PMID:37797708
The effect of ACVR1B/TGFBR1/ACVR1C signaling inhibition on oocyte and granulosa cell development during in vitro growth culture., PMID:37722883
Expression Levels of the Tnni3k Gene in the Heart Are Highly Associated with Cardiac and Glucose Metabolism-Related Phenotypes and Functional Pathways., PMID:37628941
Bioinformatics Analysis of the Genetic and Epigenetic Alterations of Bone Morphogenetic Protein Receptors in Metastatic Breast Cancer., PMID:37486509
Aberrant expression of bone morphogenetic proteins in the disease progression and metastasis of breast cancer., PMID:37333824
Proteomic profiling of protein expression changes after 3 months-exercise in ESRD patients on hemodialysis., PMID:37085769
Abundance of ACVR1B transcript is elevated during septic conditions: Perspectives obtained from a hands-on reductionist investigation., PMID:37020544
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway., PMID:36950748
Activin A Modulates Betaglycan Shedding via the ALK4-SMAD3-Dependent Pathway in Endometriotic Cells., PMID:36551177
Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors., PMID:36403856
Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development., PMID:36273119
Comparing the potential for maternal-fetal signalling in oviparous and viviparous lizards., PMID:36252210
Genetic polymorphisms of muscular fitness in young healthy men., PMID:36166425
Regulation of Nodal signaling propagation by receptor interactions and positive feedback., PMID:36149406
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization., PMID:35730718
Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration., PMID:35323108
Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population., PMID:34666056
SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways., PMID:34576190
Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors., PMID:34440938
Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer., PMID:34356885
Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction., PMID:34237300
Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction., PMID:34214050
Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation., PMID:34003511
Functions and mechanisms of circular RNAs in regulating stem cell differentiation., PMID:33896374
Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features., PMID:33880365
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders., PMID:33586684
Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma., PMID:33457096
The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation., PMID:33421362
Discovery and Validation of Serum Autoantibodies Against Tumor-Associated Antigens as Biomarkers in Gastric Adenocarcinoma Based on the Focused Protein Arrays., PMID:33346593
Activin A improves the neurological outcome after ischemic stroke in mice by promoting oligodendroglial ACVR1B-mediated white matter remyelination., PMID:33345977
[Involvement of Notch1 and ALK4/5 Signaling Pathways in Renal Tubular Cell Death: Their Application to Clarification of Cadmium Toxicity]., PMID:33342936
The Association of Multiple Gene Variants with Ageing Skeletal Muscle Phenotypes in Elderly Women., PMID:33291384
Activin A increases human trophoblast invasion by upregulating integrin β1 through ALK4., PMID:33230889
CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress., PMID:33187540
Computational modeling of transforming growth factor β and activin a receptor complex formation in the context of promiscuous signaling regulation., PMID:32597324
The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling., PMID:32554499
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop., PMID:32515349
miR-185 inhibits prostate cancer angiogenesis induced by the nodal/ALK4 pathway., PMID:32366240
Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts., PMID:32295230
Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity., PMID:32215602
For research use only. Not for human or drug use.
