Catalog No.
YHE17801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val86-Pro331
Predicted molecular weight
29.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36507
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAP kinase kinase 2, MAPK/ERK kinase 2, ERK activator kinase 2, MAPKK 2, PRKMK2, MAP2K2, MEK 2, MEK2, MKK2, Dual specificity mitogen-activated protein kinase kinase 2
MAP2K2 Knockdown Suppresses Phenotypic Transformation of Vascular Smooth Muscle Cells in Aortic Dissection by Inactivating the JAK/STAT Signaling Pathway., PMID:40437968
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease., PMID:40367191
Precision proteogenomics reveals pan-cancer impact of germline variants., PMID:40233739
A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC)., PMID:40211189
Sperm tRNA-derived fragments expression is potentially linked to abstinence-related improvement of sperm quality., PMID:40101124
Antiviral Activity of the MEK1/2 Inhibitor Trametinib Against Lymphocytic Choriomeningitis Virus., PMID:40008425
Influenza H5Nx viruses are susceptible to MEK1/2 inhibition by zapnometinib., PMID:39976482
Expanding the clinical spectrum of 19p13.3 microduplication syndrome: a case report highlighting nephrotic syndrome and literature review., PMID:39875952
The positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma., PMID:39781472
Integrin α1 upregulation by TF:FVIIa complex promotes cervical cancer migration through PAR2-dependent MEK1/2 activation., PMID:39657349
Adolescent exposure to organophosphate insecticide malathion induces spermatogenesis dysfunction in mice by activating the HIF-1/MAPK/PI3K pathway., PMID:39476999
Low PD-L1 expression, MAP2K2 alterations, and enriched HPV gene signatures characterize brain metastases in head and neck squamous cell carcinoma., PMID:39438862
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB., PMID:39438476
Imaging the Raf-MEK-ERK Signaling Cascade in Living Cells., PMID:39408915
MEK1/2 promote ROS production and deubiquitinate NLRP3 independent of ERK1/2 during NLRP3 inflammasome activation., PMID:39396647
Combined MEK1/2 and ATR inhibition promotes myeloma cell death through a STAT3-dependent mechanism in vitro and in vivo., PMID:39379134
VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17., PMID:39354506
Distinct FLT3 Pathways Gene Expression Profiles in Pediatric De Novo Acute Lymphoblastic and Myeloid Leukemia with FLT3 Mutations: Implications for Targeted Therapy., PMID:39273530
EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis., PMID:39102432
[Mechanism of electroacupuncture for vascular dementia based on proteomics]., PMID:38986595
Investigating druggable kinases for targeted therapy in retinoblastoma., PMID:38956221
MEK1/2- and ERK1/2-Mediated Lung Endothelial Injury and Altered Hemostasis Promote Diffuse Alveolar Hemorrhage in Murine Lupus., PMID:38923837
Human Genetics of Atrial Septal Defect., PMID:38884726
MicroRNA-2285f regulates milk fat metabolism by targeting MAP2K2 in bovine mammary epithelial cells., PMID:38798178
Effects of MEK1/2 inhibitor U0126 on FGF10-enhanced buffalo oocyte maturation in vitro., PMID:38643607
Proteome-based molecular subtyping and therapeutic target prediction in gastric cancer., PMID:38627210
Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy., PMID:38613141
Yak IGFBP3 promotes hepatocyte proliferation through PI3K-Akt signaling pathway., PMID:38604506
Modeling Molecular Mechanisms of Pirfenidone Interaction with Kinases., PMID:38585747
Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab., PMID:38557266
Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A., PMID:38445655
Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis., PMID:38259097
MEK1/2-PKM2 Pathway Modulates the Immunometabolic Reprogramming of Proinflammatory Allograft-infiltrating Macrophages During Heart Transplant Rejection., PMID:38238904
DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved., PMID:38139431
Exploring potential genes and mechanisms linking erectile dysfunction and depression., PMID:38111702
Characterization of the genomic alterations in poorly differentiated thyroid cancer., PMID:37932340
Functional enrichment analysis of mutated genes in children with hyperthyroidism., PMID:37876543
Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation., PMID:37708276
Post-transcriptional modification of m6A methylase METTL3 regulates ERK-induced androgen-deprived treatment resistance prostate cancer., PMID:37095108
Copper metabolism in cell death and autophagy., PMID:37055935
ERK2 Mutations Affect Interactions, Localization, and Dimerization., PMID:37021821
[Phosphoproteomic analysis of human umbilical venous endothelial cells with DENV-2 infection]., PMID:36856207
Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus., PMID:36736734
Lnc_000048 Promotes Histone H3K4 Methylation of MAP2K2 to Reduce Plaque Stability by Recruiting KDM1A in Carotid Atherosclerosis., PMID:36689133
Analysis of Long Noncoding RNAs-Related Regulatory Mechanisms in Duchenne Muscular Dystrophy Using a Disease-Related lncRNA-mRNA Pathway Network., PMID:36619896
Activation of MAP2K signaling by genetic engineering or HF-rTMS promotes corticospinal axon sprouting and functional regeneration., PMID:36599003
Infantile epileptic spasms syndrome in children with cardiofaciocutanous syndrome: Clinical presentation and associations with genotype., PMID:36448195
Case report: The cardio-facio-cutaneous syndrome due to a novel germline mutation in MAP2K1: A multifaceted disease with immunodeficiency and short stature., PMID:36313893
Mediation by DNA methylation on the association of BMI and serum uric acid in Chinese monozygotic twins., PMID:36243213
For research use only. Not for human or drug use.
