Catalog No.
YHE07001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln5-Phe140
Predicted molecular weight
16.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35080
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PFN2, Profilin-2, Profilin II
The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma., PMID:40442707
Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2., PMID:40078324
HnRNPA2B1 promotes cardiac ferroptosis via m6A-dependent stabilization of PFN2 mRNA in myocardial ischemia-reperfusion injury., PMID:40010516
VAMP8 as a biomarker and potential therapeutic target for endothelial cell dysfunction in atherosclerosis., PMID:39800194
Cytoskeleton dysfunction of motor neuron in spinal muscular atrophy., PMID:39666039
Autophagy modulates male fertility in Arabidopsis., PMID:39663590
FHOD-1 and profilin protect sarcomeres against contraction-induced deformation> in C. elegans., PMID:39259762
The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells., PMID:39256760
Sequential window acquisition of all theoretical mass spectra (SWATH-MS) as an emerging proteomics approach for the discovery of dark-cutting beef biomarkers., PMID:39096797
FHOD-1/profilin-mediated actin assembly protects sarcomeres against contraction-induced deformation in C. elegans., PMID:38559004
Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis., PMID:38539084
Disruption of OVOL2 Distal Regulatory Elements as a Possible Mechanism Implicated in Corneal Endothelial Dystrophy., PMID:40225920
Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial-mesenchymal transition via PFN2 delivery., PMID:37953354
Hsa_circ_0020134 promotes liver metastasis of colorectal cancer through the miR-183-5p-PFN2-TGF-β/Smad axis., PMID:37925795
ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation., PMID:37676718
Hypoxia-based classification and prognostic signature for clinical management of hepatocellular carcinoma., PMID:37481543
Genetic dissection of behavioral traits related to successful training of drug detection dogs., PMID:37147374
A novel Alzheimer's disease prognostic signature: identification and analysis of glutamine metabolism genes in immunogenicity and immunotherapy efficacy., PMID:37106067
Exploration and validation of the prognostic value of RNA-binding proteins in hepatocellular carcinoma., PMID:36524514
Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation., PMID:36245269
Knockdown of circ-ADAM9 inhibits malignant phenotype and enhances radiosensitivity in breast cancer cells via acting as a sponge for miR-383-5p., PMID:36205752
Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism., PMID:36028507
Identification of Antitumor miR-30e-5p Controlled Genes; Diagnostic and Prognostic Biomarkers for Head and Neck Squamous Cell Carcinoma., PMID:35886008
[Biocompatibility evaluation of electrospun PLCL/fibrinogen nanofibers in anterior cruciate ligament reconstruction]., PMID:35788524
Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm., PMID:35693827
MiR-200b-3p is upregulated in the placental tissues from patients with preeclampsia and promotes the development of preeclampsia via targeting profilin 2., PMID:35613309
Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p., PMID:35445786
OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer., PMID:35413990
[Profilin 2 is highly expressed in gastric cancer and promotes tumor cell proliferation and migration]., PMID:35365445
Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis., PMID:35239064
MicroRNA-151 regulates the growth, drug sensitivity and epithelial mesenchymal transition of human glioma cells by targeting profilin 2., PMID:35232010
Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure., PMID:34571959
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy., PMID:34238215
The exploration of a new environment leads to the modulation of gene expression for prolonged times in the rat., PMID:33821468
Profilin 3 genetic architecture in glioma formalin fixed paraffin embedded (FFPE) archive., PMID:33775850
High-speed atomic force microscopy to study pore-forming proteins., PMID:33712187
Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension., PMID:33316641
miRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma., PMID:33279650
Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes., PMID:33234737
Functional characterization and gene expression profile of perforin-2 in starry flounder (Platichthys stellatus)., PMID:33217563
Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells., PMID:33047272
PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin., PMID:32978259
MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis., PMID:32788350
In utero exposure to low doses of genistein and di-(2-ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes., PMID:32533902
Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p., PMID:32522014
Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity., PMID:32064340
Analysis of FUS, PFN2, TDP-43, and PLS3 as potential disease severity modifiers in spinal muscular atrophy., PMID:32042914
Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal., PMID:31965003
Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics., PMID:31908005
Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways., PMID:31901866
For research use only. Not for human or drug use.
