Catalog No.
YHE04601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln29-Gly147
Predicted molecular weight
16.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P34096
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RNS4, Ribonuclease 4, RNase 4, RNASE4
RNASE4 promotes malignant progression and chemoresistance in hypoxic glioblastoma via activation of AXL/AKT and NF-κB/cIAPs signaling pathways., PMID:39417186
Ribonuclease 4 functions as an intestinal antimicrobial protein to maintain gut microbiota and metabolite homeostasis., PMID:38987259
Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection., PMID:36652479
Senescent cells limit p53 activity via multiple mechanisms to remain viable., PMID:35764649
Ribonuclease 4 is associated with aggressiveness and progression of prostate cancer., PMID:35752711
Construction of miRNA-mRNA-TF Regulatory Network for Diagnosis of Gastric Cancer., PMID:34840985
Expression and function of human ribonuclease 4 in the kidney and urinary tract., PMID:33818125
Genome-wide association study for age at puberty in young Nelore bulls., PMID:31515857
Urinary defense begins in the kidney., PMID:31445577
Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study., PMID:31368019
Genetic associations of the vitamin D and antiviral pathways with natural resistance to HIV-1 infection are influenced by interpopulation variability., PMID:31103723
Weighted correlation network and differential expression analyses identify candidate genes associated with BRAF gene in melanoma., PMID:30925905
A molecular dynamics based investigation reveals the role of rare Ribonuclease 4 variants in amyotrophic lateral sclerosis susceptibility., PMID:30544007
Identification of differentially expressed genes and regulatory relationships in Huntington's disease by bioinformatics analysis., PMID:29328442
Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis., PMID:29279004
Abundance of RNase4 and RNase5 mRNA and protein in host defence related tissues and secretions in cattle., PMID:28955965
Cell-specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct., PMID:28468965
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology., PMID:27956139
Bovine milk RNases modulate pro-inflammatory responses induced by nucleic acids in cultured immune and epithelial cells., PMID:27871831
Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop., PMID:24659782
The expansion and functional diversification of the mammalian ribonuclease a superfamily epitomizes the efficiency of multigene families at generating biological novelty., PMID:24162010
Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress., PMID:23143660
The mammalian secreted RNases: mechanisms of action in host defence., PMID:22627784
Host-defence-related proteins in cows' milk., PMID:22436220
In vitro biological activity of bovine milk ribonuclease-4., PMID:21472211
The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression., PMID:15722482
Toward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor., PMID:10441122
The angiogenins., PMID:9760990
For research use only. Not for human or drug use.
