Catalog No.
EHE01901
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln39-Pro193
Predicted molecular weight
44.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>85% as determined by SDS-PAGE.
Accession
P32970
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD27 ligand, CD70, TNFSF7, CD27LG, CD27L, CD70 antigen, Tumor necrosis factor ligand superfamily member 7, CD27-L
Hepatic transcriptome profiling unveils candidate genes in cattle with liver abscesses under the influence of beef genetics in dairy cattle., PMID:40489480
CD70 CAR-T cells empowered by TS-2021 through ex vivo transduction show potent antitumor efficacy against glioblastoma., PMID:40474210
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study., PMID:40404633
CD70-Targeted [18F]RCCB6 Immuno-PET/CT Imaging in Patients with Nasopharyngeal Carcinoma: A Proof-of-Concept Study., PMID:40306966
Regulation mechanism of chemokine CXCL3 in nasopharyngeal carcinoma., PMID:40239601
CD70 recruitment to the immunological synapse is dependent on CD20 in B cells., PMID:40232798
Cadmium disrupted homeostasis of proximal renal tubular cells via targeting ATF4-CHOP complex into the nucleus., PMID:40220672
Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer., PMID:40205178
Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling., PMID:40165944
Soluble CD27 differentially predicts resistance to anti-PD1 alone but not with anti-CTLA-4 in melanoma., PMID:40148586
Comprehensive pan-cancer analysis reveals CD70 as a promising therapeutic target and biomarker in clear cell renal cell carcinoma., PMID:40113005
Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4-related ophthalmic disease., PMID:40078987
CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity., PMID:40046047
The DHH-DHHA1 domain phosphodiesterase of Mycoplasma bovis employs multiple strategies to modulate macrophage cellular processes., PMID:40023422
Development and Preclinical Evaluation of [64Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics., PMID:40015924
A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells., PMID:39906740
Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes., PMID:39867912
CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells., PMID:39793572
Direct Inhibitory Effect of HTLV-1-Infected T Cells on the Production of Anti-Ro/SS-A Antibody by B Cells from Patients with Sjögren's Syndrome., PMID:39775490
A mechanistic, functional, and clinical perspective on targeting CD70 in cancer., PMID:39725151
Diagnostic and predictive values of m5C‑associated genes in idiopathic pulmonary fibrosis., PMID:39704195
Safety and activity of CTX130, a CD70-targeted allogeneic CRISPR-Cas9-engineered CAR T-cell therapy, in patients with relapsed or refractory T-cell malignancies (COBALT-LYM): a single-arm, open-label, phase 1, dose-escalation study., PMID:39617017
CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual-targeting antibody overcome antigen heterogeneity in AML., PMID:39571145
CD70: An Emerging Anticancer Target in Renal Cell Carcinoma and Beyond., PMID:39570653
IL-21/IL-21R signaling renders acute myeloid leukemia stem cells more susceptible to cytarabine treatment and CAR T cell therapy., PMID:39536753
CD70-Targeted Immuno-PET/CT Imaging of Clear Cell Renal Cell Carcinoma: A Translational Study., PMID:39510586
The future of cellular therapy for the treatment of renal cell carcinoma., PMID:39485013
Significance of CD70, VEGF, and CD90 Immunohistochemical Expression in Colorectal Cancer., PMID:39471037
CD70 is a potential prognostic marker and significantly regulates cellular function in diffuse large B-cell lymphoma., PMID:39446784
Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset., PMID:39432735
Mechanism of ginsenoside Rb3 against OGD/R damage based on metabonomic and PCR array analyses., PMID:39420925
Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC., PMID:39411143
Integrated multi-omics profiling reveals the ZZZ3/CD70 axis is a super-enhancer-driven regulator of diffuse large B-cell lymphoma cell-natural killer cell interactions., PMID:39376717
Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia., PMID:39285441
Pediatric Plasmablastic Lymphoma in the Setting of CD70 Deficiency., PMID:39262383
The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma., PMID:39227950
Development of bioassay platforms for biopharmaceuticals using Jurkat-CAR cells by AICD., PMID:39197208
Cadmium causes cerebral mitochondrial dysfunction through regulating mitochondrial HSF1., PMID:39127336
'Living drugs' target CD70 in advanced renal tumors., PMID:39079777
Noninvasive prediction of CCL2 expression level in high-grade glioma patients., PMID:39030882
CD70 identifies alloreactive T cells and represents a potential target for prevention and treatment of acute GVHD., PMID:39028952
CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis., PMID:38900051
Knocking Out CD70 Rescues CD70-Specific NanoCAR T Cells from Antigen-Induced Exhaustion., PMID:38874582
Re: CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma., PMID:38735819
Expression of Potential Antibody-Drug Conjugate Targets in Cervical Cancer., PMID:38730739
The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells., PMID:38683145
The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment., PMID:38637886
Single-cell sequencing analysis and multiple machine-learning models revealed the cellular crosstalk of dendritic cells and identified FABP5 and KLRB1 as novel biomarkers for psoriasis., PMID:38596682
CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma., PMID:38583184
CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy., PMID:38564778
For research use only. Not for human or drug use.
