Catalog No.
YHD96301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala181-Ser252
Predicted molecular weight
35.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P31645
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
5HT transporter, 5HTT, SERT, Sodium-dependent serotonin transporter, Solute carrier family 6 member 4, HTT, SLC6A4
A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing., PMID:40500269
Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development., PMID:40485115
Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding., PMID:40467568
Prenatal serotonin depletion persistently disrupts social behavior and modulates ΔFosB and SERT expression in mice., PMID:40451488
Molecular Effect of Variants in Serotonin Transporter Gene in Women with Alcohol Use Disorder., PMID:40422201
The influence of genetic factors on the severity of anxiety and depressive symptoms and the choice of coping strategies in reproductive tract cancer-a preliminary study., PMID:40416692
Integrating click chemistry into protein expression for efficient preparation of immobilized protein bio-surface with enhanced stability and reproducibility in affinity chromatography., PMID:40409903
Athlete burnout and biomarkers: An exploratory, longitudinal N-of-1 study., PMID:40374022
Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats., PMID:40372776
Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population., PMID:40369544
Dynamic Model of Serotonin Presynapse and Its Application to Suicide Attempt in Patients with Bipolar Disorder., PMID:40362322
The interplay between SLC6A4 and HTR1A genetic variants that may lead to antidepressant failure., PMID:40335484
The serotonin gene 5-HTTLPR and brain food-reward responses during sadness: a mood-induction neuroimaging study., PMID:40334849
Analysis of Serotonin Transporter Gene 5-HTTLPR Polymorphism and Its Impact on Personality Traits in a Sample Without Neuropsychiatric or Substance Use Disorders., PMID:40332353
Serotonin innervation of the subthalamic nucleus in parkinsonian monkeys., PMID:40320179
Exploring the association between serotonin transporter promoter region methylation levels and depressive symptoms: a systematic review and multi-level meta-analysis., PMID:40319044
Immobilizing the Endogenous 5-Hydroxytryptamine Transporter by Ligand-Directed and Proximity-Catalyzed Acyl Imidazole Chemistry for Affinity Chromatographic Analysis., PMID:40317770
Serotonin Transporter Gene Polymorphisms Predict Adherence to Weight Loss Programs Independently of Obesity-Related Genes., PMID:40292541
A comparative exploration of monoamine neurotransmitter transport disorders: mechanisms, clinical manifestations, and therapeutic approaches., PMID:40291937
Stress sensitization to psychological adjustment following childhood adversity: Moderation by serotonergic multilocus genetic variation., PMID:40274118
Careful Examination of a Novel Azobenzene Paroxetine Derivative and Its Interactions With Biogenic Amine Transporters., PMID:40270279
Investigating the mechanism of action of the Mongolian Medicine Areca Thirteen Pill (GY-13) in treating major depressive disorder based on integrated pharmacology., PMID:40258735
Cigarette smoking is associated with levels of the serotonin transporter in the brain: a [11C]DASB PET Study., PMID:40258113
Control of Conformational Transitions by the Conserved GX9P Motif in the Fifth Transmembrane Domain of Neurotransmitter Sodium Symporters., PMID:40243663
Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion., PMID:40221064
Disruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio)., PMID:40216344
[Pharmacology of novel, fast-acting, non-monoaminergic antidepressants]., PMID:40173429
Unveiling the potential abuse liability of α-D2PV: A novel α-carbon phenyl-substituted synthetic cathinone., PMID:40118207
Summer and SERT: Effect of daily sunshine hours on SLC6A4 promoter methylation in seasonal affective disorder., PMID:40114401
Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation., PMID:40077671
Epigenetics in persons living with HIV: trauma, coping, and FKBP5 and SLC6A4 methylation., PMID:40069093
Molecular basis for the effects of SSRIs in non-target aquatic invertebrates: A case study with Mytilus galloprovincialis early larvae., PMID:40068373
Genetic determinants of longitudinal behavioural trajectories in rare conditions: The case of fragile X syndrome., PMID:40054504
Serotonergic dysfunction in patients with impulse control disorders in Parkinson's disease., PMID:40042882
Serotonin regulates in a cell-type specific manner light-evoked response and synaptic activity in mouse retinal ganglion cells., PMID:40033464
[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation., PMID:40025148
The effect of Psilocybe cubensis alkaloids on depressive-like behavior in mice exposed to maternal separation with respect to hippocampal gene expression and DNA methylation of Slc6a4 and Nr3c1., PMID:39969076
Phytoconstituents of Hericium erinaceus Exert Benefits for ADHD Conditions by Targeting SLC6A4: Extraction, Spectroscopic Characterization, Phytochemical Screening, In Vitro, and Computational Perspectives., PMID:39959106
D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants., PMID:39952098
Machine Learning Tool for New Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitors., PMID:39942741
Quantifying multilabeled brain cells in the whole prefrontal cortex reveals reduced inhibitory and a subtype of excitatory neuronal marker expression in serotonin transporter knockout rats., PMID:39932853
More and Less Fear in Serotonin Transporter Knockout Mice., PMID:39917838
Efficient and modular synthesis of ibogaine and related alkaloids., PMID:39915657
Adolescent Depression and Cognition Risk for Suicide: An Investigation of Risk Factors and Gene Environment Interactions., PMID:39910899
Mice lacking the serotonin transporter do not respond to the behavioural effects of psilocybin., PMID:39864573
SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors., PMID:39862090
Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis., PMID:39839219
Inhibitory effects of Valeriana fauriei root extract on serotonin uptake in vitro caused by the interaction among its active ingredients including a new compound., PMID:39832628
Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression., PMID:39809809
The Relationship Between Impulsivity Traits and In Vivo Cerebral Serotonin Transporter and Serotonin 2A Receptor Binding in Healthy Individuals: A Double-Tracer PET Study with C-11 DASB and C-11 MDL100907., PMID:39796107
For research use only. Not for human or drug use.
