Catalog No.
YHD84101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn120-Asp297
Predicted molecular weight
22.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P29466
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL1BC, Interleukin-1 beta-converting enzyme, p45, Caspase-1, IL-1BC, IL-1 beta-converting enzyme, CASP1, IL1BCE, ICE, CASP-1, Interleukin-1 beta convertase
The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein., PMID:40512405
MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection., PMID:40510795
The Prognostic Significance of TMSB4X in Glioma Patients., PMID:40502330
Ultraviolet radiation induces caspase cleavage and nuclear translocation of heme oxygenase 1 (HO-1) to activate autophagy in skin keratinocytes., PMID:40488590
Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates., PMID:40486518
Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANoptosis Inhibition., PMID:40463856
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis., PMID:40462493
Macrophage histone lactylation in atherosclerosis progression: mechanisms, predictive models, and therapeutic potential of Ruan Jian Qing Mai formula., PMID:40449878
Polysaccharide of Atractylodes macrocephala Koidz alleviated fructose-induced salt-sensitive hypertension and renal injury via suppressing SIRT1/Nlrp3/caspase-1 pathway in mice., PMID:40446979
Identifying potential co-expressed genes and molecular mechanisms linking post-COVID-19 and Guillain-Barre syndrome through neutrophil extracellular trap-related genes., PMID:40433617
Transcriptomic and Immunopathological Profiles of Inflammasomes in Different Clinical Forms of American Cutaneous Leishmaniasis., PMID:40431153
Activation of the NALP3-CASP1-IL-1 β Inflammatory Pathway by Pesticide Exposure in Human Umbilical Vein Endothelial Cells., PMID:40430087
BAM15 inhibits endothelial pyroptosis via the NLRP3/ASC/caspase-1 pathway to alleviate atherosclerosis., PMID:40393254
Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation., PMID:40375539
Disruption of the caspase-1/IL-1β axis alleviates myocardial Ischemia/Reperfusion injury via improvement of mitochondrial homeostasis and reduction of Pyroptosis., PMID:40373207
miR-126-5p protects from URSA via inhibiting Caspase-1-dependent pyroptosis of trophoblast cells., PMID:40372489
Qilian Jiechang Ning Alleviates TNBS-Induced Ulcerative Colitis in Mice and Segatella copri Outer Membrane Vesicle-Triggered Inflammation in Colon Epithelial Cells via the Caspase-1/11-GSDMD Pathways., PMID:40367931
Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia., PMID:40359428
Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats., PMID:40332346
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways., PMID:40331897
Bee venom ameliorates gentamicin-induced kidney injury by restoring renal aquaporins and enhancing antioxidant and anti-inflammatory activities in rats., PMID:40313618
Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis., PMID:40308566
Adiponectin alleviates inflammatory response in metabolic dysfunction-associated steatohepatitis by inhibiting NLRP3 inflammasome-mediated hepatocyte pyroptosis., PMID:40307114
Prediction of the neurotoxic mechanisms of the pesticide phorate using network toxicology, molecular docking, and molecular dynamics simulation., PMID:40293390
Pathways regulating the levels of tissue factor-positive extracellular vesicles and activation of coagulation in endotoxemic mice., PMID:40286911
Roles of PANoptosis and related genes in acute liver failure: neoteric insight from bioinformatics analysis and animal experiment verification., PMID:40274384
Keto Acids Attenuate Skeletal Muscle Atrophy in Chronic Kidney Disease via Inhibiting Pyroptosis and Upregulating Irisin Precursor FNDC5 Expression., PMID:40272551
Study on the mechanism of action of the active ingredient of Calculus Bovis in the treatment of sepsis by integrating single-cell sequencing and machine learning., PMID:40258762
Fasudil mitigates diabetes-associated cognitive decline and enhances neuroprotection by suppressing NLRP3/Caspase-1/GSDMD signaling in a stroke mouse model., PMID:40250699
Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches., PMID:40247811
Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway., PMID:40228672
Effect of the MIAT/microRNA 130a-3p/Pdgfra axis on retinal microglia activation in mice with chronic retinal hypoperfusion injury., PMID:40216630
Identification and validation of pyroptosis patterns in AML via comprehensive bioinformatics analysis., PMID:40208371
Nd:YAG1064nm laser functions against Sporothrix globosa by inducing PANoptosis via the regulation of ZBP1-induced PANoptosome activation., PMID:40207151
TPL2 kinase activity is required for Il1b transcription during LPS priming but dispensable for NLRP3 inflammasome activation., PMID:40170849
Photobiomodulation regulates inflammation and autophagy in spinal cord injury through NLRP3/Caspase-1/IL-1β pathway by targeting TLR2., PMID:40157277
Analysis of the molecular mechanisms of ulcerative colitis and atherosclerosis by microarray data., PMID:40155679
Aspartame increases the risk of liver cancer through CASP1 protein: A comprehensive network analysis insights., PMID:40139029
A tightly regulated auxin signaling landscape is required for spatial accommodation of lateral roots in Arabidopsis., PMID:40133999
HDAC1 Promotes Hippocampal Neuronal Pyroptosis in Epileptic Mice Through the miR-15a-5p/Caspase-1 Axis., PMID:40131574
Caspase-1 is critical for mice in the defense against Streptococcus equi subsp. zooepidemicus infection by promoting macrophage phagocytosis., PMID:40122410
Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection., PMID:40092991
CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR-494-3p/CASP1/GSDMD-N/IL-1β pathway., PMID:40090540
Screening necroptosis genes influencing osteoarthritis development based on machine learning., PMID:40089565
Physicochemical and colon cancer HT-29 cell inhibitory property of homogeneous polysaccharide from Stropharia rugosoannulata., PMID:40081691
Impact of sodium butyrate on stroke-related intestinal injury in diabetic mice: Interference with Caspase-1/GSDMD pyroptosis pathway and preservation of intestinal barrier., PMID:40057153
Gegen Qinlian Decoction improves Alzheimer's disease through TLR4/NF-κB/NLRP3 pathway., PMID:40056656
[The HMGB1, caspase-1 and gasdermin D-mediated pyroptosis in high-altitude retinopathy: an experimental study]., PMID:40050105
Microbial Butyrate Modified by Melatonin Alleviates Colon Inflammation by Inhibiting GPR109A/Caspase-1-Dependent Macrophage M1 Polarization., PMID:40042189
Inhibition of NLRP3 alleviates calcium oxalate crystal-induced renal fibrosis and crystal adhesion., PMID:40035889
For research use only. Not for human or drug use.
