Catalog No.
YHD76001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser24-Gln300
Predicted molecular weight
33.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28039
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
AOAH, Acyloxyacyl hydrolase
A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide., PMID:40271687
Histone H3 lysine 9 tri-methylation is associated with pterygium., PMID:40033254
Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk., PMID:38904010
Abscisic acid for acute respiratory distress syndrome therapy by suppressing alveolar macrophage pyroptosis via upregulating acyloxyacyl hydrolase expression., PMID:38849041
The LPS-inactivating enzyme acyloxyacyl hydrolase protects the brain from experimental stroke., PMID:38522823
Immune activity score to assess the prognosis, immunotherapy and chemotherapy response in gastric cancer and experimental validation., PMID:38025711
Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance., PMID:37498977
Exploring the molecular targets and mechanism of S. miltiorrhiza-C. aromatica in treating polycystic ovary syndrome based on network pharmacology., PMID:36846000
PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity., PMID:36588164
Identification of Genomic Regions and Candidate Genes Associated with Body Weight and Body Conformation Traits in Karachai Goats., PMID:36292658
Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice., PMID:36112153
Phospholipase activity of acyloxyacyl hydrolase induces IL-22-producing CD1a-autoreactive T cells in individuals with psoriasis., PMID:34913478
Proteomic analysis exploring the mechanism of bladder fibrosis induced by ketamine using a rat model., PMID:34532254
Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report., PMID:33766120
How Phagocytic Cells Kill Different Bacteria: a Quantitative Analysis Using Dictyostelium discoideum., PMID:33593980
Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery., PMID:33454018
Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Non-invasive Early Biomarkers of Alzheimer's Disease in 5XFAD Mouse Model., PMID:33250918
Physical Exercise Exacerbates Acute Kidney Injury Induced by LPS via Toll-Like Receptor 4., PMID:32765291
HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression., PMID:32332915
Acyloxyacyl hydrolase regulates voiding activity., PMID:32003596
Analysis of the basal colonic innate immune response of pigs divergent in feed efficiency and following an ex vivo lipopolysaccharide challenge., PMID:31322475
Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor., PMID:31017816
Crystal structure of the mammalian lipopolysaccharide detoxifier., PMID:29343645
Acyloxyacyl hydrolase modulates pelvic pain severity., PMID:29118019
Western-diet consumption induces alteration of barrier function mechanisms in the ileum that correlates with metabolic endotoxemia in rats., PMID:28400412
Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling., PMID:27554816
CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis., PMID:27293313
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease., PMID:26619808
Sequencing of candidate genes in Dominican families implicates both rare exonic and common non-exonic variants for carotid intima-media thickness at bifurcation., PMID:26319989
Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs., PMID:26138468
Somatic amplifications and deletions in genome of papillary thyroid carcinomas., PMID:25863487
Microarray analysis of inflammatory response-related gene expression in the uteri of dogs with pyometra., PMID:25620174
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity., PMID:24344308
Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study., PMID:22723975
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles., PMID:22446964
Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes., PMID:22441700
Contribution of different placental cells to the expression and stimulation of antimicrobial proteins (AMPs)., PMID:21899884
Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin., PMID:21674560
Genetics of rhinosinusitis., PMID:21499907
Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo., PMID:19860560
Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection., PMID:18779055
Host defense genes in asthma and sepsis and the role of the environment., PMID:17989521
Gene amplifications at chromosome 7 of the human gastric cancer genome., PMID:17611641
A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen., PMID:17322564
Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase., PMID:17227775
Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes., PMID:16815140
Use of human cDNA microarrays for identification of differentially expressed genes in Atlantic salmon liver during Aeromonas salmonicida infection., PMID:14508654
Deacylation of purified lipopolysaccharides by cellular and extracellular components of a sterile rabbit peritoneal inflammatory exudate., PMID:10377115
Neutrophil activation associated with increased neutrophil acyloxyacyl hydrolase activity during inflammation in cattle., PMID:1381878
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides., PMID:1883828
For research use only. Not for human or drug use.
