Catalog No.
YHD74601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro575-Pro743
Predicted molecular weight
20.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P27658
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
COL8A1, Endothelial collagen, C3orf7, Collagen alpha-1(VIII) chain
Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in Glioblastoma., PMID:40496929
In Silico Analysis of Novel circRNA-miRNA-mRNA Axis in BRAFV600E Melanoma: Implications for Primary to Metastasis Transformation and TIME Modulation., PMID:40436810
A spatially resolved transcriptome landscape during thyroid cancer progression., PMID:40157360
LPAR3 and COL8A1, as matrix stiffness-related biomarkers, promote nasopharyngeal carcinoma metastasis by triggering EMT and angiogenesis., PMID:40049264
SPP1hi macrophages, NKG7 T cells, CCL5hi fibroblasts, and IgM plasma cells are dominant features of necrobiosis., PMID:39989459
THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer., PMID:39732719
Identification of fibrosis-associated biomarkers in heart failure and human cancers., PMID:39563337
Integrative transcriptome analysis reveals Serpine2 promotes glomerular mesangial cell proliferation and extracellular matrix accumulation via activating ERK1/2 signalling pathway in diabetic nephropathy., PMID:39557806
High expression of COL8A1 predicts poor prognosis and promotes EMT in papillary thyroid cancer., PMID:39377348
Targeting CD13/Aminopeptidase N as a Novel Therapeutic Approach for Scleroderma Fibrosis., PMID:39175116
Collagen VIII in vascular diseases., PMID:39154854
Diagnostic biomarkers in knee osteoarthritis: Based on bioinformatics and experimental verification in vivo and in vitro., PMID:39110784
Exudative Age-Related Macular Degeneration: Association between Treatment Efficacy and Single-Nucleotide Variants in RAD51B, TRIB1, COL8A1, COL10A1, IL-9, IL-10, and VEGFA Genes., PMID:38999967
Identification of LRRC46 as a novel candidate gene for high myopia., PMID:38874710
KDM3A knockdown regulates COMP, LOX, COL8A1 and ACOT1 genes in myocardial fibrosis., PMID:38854759
A murine model of hypertensive heart disease in older women., PMID:38799057
COL8A1 is a potential prognostic biomarker associated with migration, proliferation, and tumor microenvironment in glioma., PMID:38719174
Two patients with Knobloch syndrome due to mutation in COL8A1 gene: case report and review of the literature., PMID:38575892
COL8A1 Regulates Esophageal Squamous Carcinoma Proliferation and Invasion Through PI3K/AKT Pathway., PMID:38429534
Impact of culture media on primary human corneal endothelial cells derived from old donors., PMID:38316204
Molecular prognostic of nine parthanatos death-related genes in glioma, particularly in COL8A1 identification., PMID:38225203
The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer-associated fibroblast subtypes., PMID:37728068
DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database., PMID:37716425
Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis., PMID:37471168
Identification and validation of an ECM organization-related gene signature as a prognostic biomarker and therapeutic target for glioma patients., PMID:37301776
MicroRNA-210-3p Regulates Endometriotic Lesion Development by Targeting IGFBP3 in Baboons and Women with Endometriosis., PMID:37188982
The Associations of Single Nucleotide Polymorphisms of the COL3A1, COL6A5, and COL8A1 Genes with Atopic Dermatitis., PMID:37109047
Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells., PMID:36949528
COL8A1 enhances the invasion/metastasis in MDA-MB-231 cells via the induction of IL1B and MMP1 expression., PMID:36577251
Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action., PMID:36552714
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma., PMID:36375776
[Construction of zebrafish models for screening intracranial hemorrhage associated genes]., PMID:36058688
Clinical Value Screening, Prognostic Significance, and Key Gene Identification of TrkB in Laryngeal Carcinoma., PMID:36033826
Identification and Verification of Potential Biomarkers in Gastric Cancer By Integrated Bioinformatic Analysis., PMID:35910202
Transcriptomic Profile of Genes Regulating the Structural Organization of Porcine Atrial Cardiomyocytes during Primary In Vitro Culture., PMID:35885988
COL8A1 Predicts the Clinical Prognosis of Gastric Cancer and Is Related to Epithelial-Mesenchymal Transition., PMID:35774273
Integrated Bioinformatics Analysis for Identifying the Significant Genes as Poor Prognostic Markers in Gastric Adenocarcinoma., PMID:35726219
COL8A1 facilitates the growth of triple-negative breast cancer via FAK/Src activation., PMID:35624176
Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy)., PMID:35581286
Methodological study of directed differentiation of pluripotent stem cells into corneal endothelial cells., PMID:35571395
Recognition of a Novel Gene Signature for Human Glioblastoma., PMID:35456975
Clinical and laboratory characterization of patients with localized scleroderma and response to UVA-1 phototherapy: In vivo and in vitro skin models., PMID:35324032
COL8A1 Promotes NSCLC Progression Through IFIT1/IFIT3-Mediated EGFR Activation., PMID:35280763
Novel Insights into the Stemness and Immune Privilege of Mesenchymal Stem Cells from Human Wharton Jelly by Single-Cell RNA Sequencing., PMID:35153292
Genetic and environmental risk factors for reticular pseudodrusen in the EUGENDA study., PMID:35136347
The clinical significance of transcription factor WD repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma and its potential molecular mechanism., PMID:34999279
Prognostic marker identification based on weighted gene co-expression network analysis and associated in vitro confirmation in gastric cancer., PMID:34338150
A Multi-center Genome-wide Association Study of Cervical Dystonia., PMID:34320236
Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration., PMID:34060991
The effect of normal, metaplastic, and neoplastic esophageal extracellular matrix upon macrophage activation., PMID:34027260
For research use only. Not for human or drug use.
