Catalog No.
YHD65301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln396-Thr703
Predicted molecular weight
32.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25067
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endothelial collagen, Collagen alpha-2(VIII) chain, COL8A2
Genotyping methods for Fuchs corneal endothelial dystrophy., PMID:40186897
Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation., PMID:40110574
Anti-fibrotic effects of thrombin inhibition in systemic sclerosis-associated interstitial lung disease: Proof of concept., PMID:40013233
COL8A2 activation enhances function of corneal endothelial cells through HIPPO signaling/mitochondria pathway., PMID:39395654
Integrated transcriptomics and metabolomics study of embryonic breast muscle of Jiaji ducks., PMID:38824564
COL8A1 is a potential prognostic biomarker associated with migration, proliferation, and tumor microenvironment in glioma., PMID:38719174
Characterization of a Novel Mouse Model for Fuchs Endothelial Corneal Dystrophy., PMID:38587441
[Mutational Signatures Analysis of Micropapillary Components and Exploration of ZNF469 Gene in Early-stage Lung Adenocarcinoma with Ground-glass Opacities]., PMID:38151328
Gene expression profiles to analyze the anticancer and carcinogenic effects of arsenic in bladder cancer., PMID:37969188
Identification and analysis of RNA-5-methylcytosine-related key genes in osteoarthritis., PMID:37700248
Identification of the circRNA-miRNA-mRNA regulatory network in osteoarthritis using bioinformatics analysis., PMID:36186471
Fuchs endothelial corneal dystrophy: current perspectives on diagnostic pathology and genetics-Bowman Club Lecture., PMID:36161831
Comprehensive analysis of endoplasmic reticulum-related and secretome gene expression profiles in the progression of non-alcoholic fatty liver disease., PMID:36034446
Update on the genetics of corneal endothelial dystrophies., PMID:35791103
Methodological study of directed differentiation of pluripotent stem cells into corneal endothelial cells., PMID:35571395
Human platelet lysate as a replacement for fetal bovine serum in human corneal stromal keratocyte and fibroblast culture., PMID:34486211
Extracellular matrix remodeling precedes atrial fibrillation: Results of the PREDICT-AF trial., PMID:34332113
Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy., PMID:34130750
Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy., PMID:34100716
Collagen type VIII alpha 2 chain (COL8A2), an important component of the basement membrane of the corneal endothelium, facilitates the malignant development of glioblastoma cells via inducing EMT., PMID:33405048
New findings in the roles of Cyclin-dependent Kinase inhibitors 2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 G/C and rs4977574 A/G variants on the risk to coronary heart disease., PMID:33054494
COL8A2 Regulates the Fate of Corneal Endothelial Cells., PMID:32931574
Transcript Profiles of Stria Vascularis in Models of Waardenburg Syndrome., PMID:32802035
Molecular Mechanisms of Fuchs and Congenital Hereditary Endothelial Corneal Dystrophies., PMID:32789790
Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry., PMID:32687633
Successful culture of human transition zone cells., PMID:32249477
Defective cell adhesion function of solute transporter, SLC4A11, in endothelial corneal dystrophies., PMID:31691803
Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma., PMID:31285765
TCF4 and COL8A2 Gene Polymorphism Screening in a Greek Population of Late-onset Fuchs Endothelial Corneal Dystrophy., PMID:31028223
Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy., PMID:30973406
Injury induces endothelial to mesenchymal transition in the mouse corneal endothelium in vivo via FGF2., PMID:30804659
Transcription factor TFAP2B up-regulates human corneal endothelial cell-specific genes during corneal development and maintenance., PMID:30552118
Biomechanical changes to Descemet's membrane precede endothelial cell loss in an early-onset murine model of Fuchs endothelial corneal dystrophy., PMID:30471280
Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis., PMID:30217450
Functional relevance for central cornea thickness-associated genetic variants by using integrative analyses., PMID:30127857
TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts., PMID:30118525
Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells., PMID:29685994
Identification of genes associated with primary open-angle glaucoma by bioinformatics approach., PMID:28894971
Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model., PMID:28726551
Genetic factors influencing the reduction of central corneal thickness in disorders affecting the eye., PMID:28453375
Upregulation of distinct collagen transcripts in post-surgery scar tissue: a study of conjunctival fibrosis., PMID:28331057
Altered Anterior Segment Biometric Parameters in Mice Deficient in SPARC., PMID:28122087
Analysis of SLC4A11, ZEB1, LOXHD1, COL8A2 and TCF4 gene sequences in a multi-generational family with late-onset Fuchs corneal dystrophy., PMID:27121161
Fuchs Endothelial Corneal Dystrophy: A Systematic Immunofluorescence Study of Collagen Type VIII Suggests Heterogeneous Pathophysiology., PMID:27078008
Distinct Clinical Phenotype of Corneal Dystrophy Predicts the p.(Leu450Trp) Substitution in COL8A2., PMID:26989952
Mutational spectrum of Korean patients with corneal dystrophy., PMID:26748743
Efficient Generation of Human Embryonic Stem Cell-Derived Corneal Endothelial Cells by Directed Differentiation., PMID:26689688
Association of ZEB1 and TCF4 rs613872 changes with late onset Fuchs endothelial corneal dystrophy in patients from northern India., PMID:26622166
[TGC Repeats in Intron 2 of the TCF4 Gene have a Good Predictive Power Regarding to Fuchs Endothelial Corneal Dystrophy]., PMID:26280645
Loss of ion transporters and increased unfolded protein response in Fuchs' dystrophy., PMID:25548511
For research use only. Not for human or drug use.
