Catalog No.
YHD63901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala111-Leu427
Predicted molecular weight
35.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24752
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACAT, Acetoacetyl-CoA thiolase, MAT, Acetyl-CoA acetyltransferase, mitochondrial, ACAT1, T2
Comprehensive analysis of chronic hepatitis B concurrent with non-alcoholic fatty liver disease: a proteomics report based on clinical liver samples., PMID:40361009
Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer., PMID:40289129
Sesamin regulates breast cancer through reprogramming of lipid metabolism., PMID:40233124
ACAT1 regulates tertiary lymphoid structures: A target for enhancing immunotherapy in non-small cell lung cancer., PMID:40166937
ACAT1 regulates tertiary lymphoid structures and correlates with immunotherapy response in non-small cell lung cancer., PMID:40166933
Identification of Biomarkers for Meat Quality in Sichuan Goats Through 4D Label-Free Quantitative Proteomics., PMID:40150416
Genetic and metabolic insights into sexual dimorphism in the flexor carpi radialis of Asiatic toads (Bufo gargarizans) associated with amplexus behavior., PMID:39994541
Partial Regulation of Ketone Metabolism by Hypoxia in H9C2 Cardiomyocytes., PMID:39976748
ACAT1-Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production., PMID:39951294
Lipids Metabolism Inhibition Antiproliferative Synergy with 5-Fluorouracil in Human Colorectal Cancer Model., PMID:39940954
Construction and Validation of a Novel Butyrylation-Related Gene Signature Related to Prognosis, Clinical Implications, and Immune Microenvironment Characterization of Hepatocellular Carcinoma., PMID:39926543
Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation., PMID:39841826
Differential effects of β-hydroxybutyrate and α-ketoglutarate on HCT-116 colorectal cancer cell viability under normoxic and hypoxic low-glucose conditions: exploring the role of SRC, HIF1α, ACAT1, and SIRT2 genes., PMID:39833322
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains' Inflammatory Profiles., PMID:39769453
Cannabinoid receptor type 2 agonist GP1a attenuates macrophage activation induced by M. bovis-BCG by inhibiting NF-κB signaling., PMID:39538989
Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid., PMID:39525590
Panax notoginseng saponins improves lipid metabolism and prevents atherosclerosis in mice with steroid-resistant lupus nephritis via the SIRT1/PPARγ signaling pathway., PMID:39522615
ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism., PMID:39494339
Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles., PMID:39484620
ACAT1/SOAT1 maintains adipogenic ability in preadipocytes by regulating cholesterol homeostasis., PMID:39481851
Developmental and Molecular Effects of C-Type Natriuretic Peptide Supplementation in In Vitro Culture of Bovine Embryos., PMID:39456721
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1., PMID:39456234
Antioxidant Effect of Naringin Demonstrated Through a Bayes' Theorem Driven Multidisciplinary Approach Reveals its Prophylactic Potential as a Dietary Supplement for Ischemic Stroke., PMID:39352635
Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice., PMID:39273099
From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer., PMID:39247186
The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression., PMID:39125645
The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis., PMID:39080495
Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1., PMID:38994152
Anti-atherosclerotic effect of tetrahydroxy stilbene glucoside via dual-targeting of hepatic lipid metabolisms and aortic M2 macrophage polarization in ApoE-/- mice., PMID:38971092
Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study., PMID:38735387
JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines., PMID:38727296
[Clinical analysis and genetic diagnosis of three children with Isoleucine metabolic disorders due to variants of HSD17B10 and ACAT1 genes]., PMID:38684297
Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1., PMID:38673803
Dynamics of the Trypanosoma cruzi infection in adipose tissue: Assessing gene expression of PNPLA2, FASN, and ACAT1 under Benzonidazole treatment and indirect mononuclear immune cells interaction., PMID:38588892
Modulating Cholesterol Metabolism via ACAT1 Knockdown Enhances Anti-B-Cell Lymphoma Activities of CD19-Specific Chimeric Antigen Receptor T Cells by Improving the Cell Activation and Proliferation., PMID:38534399
The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts., PMID:38479452
Establishment and validation of a novel peroxisome-related gene prognostic risk model in kidney clear cell carcinoma., PMID:38297313
Silencing lncRNA-DARS-AS1 suppresses nonsmall cell lung cancer progression by stimulating miR-302a-3p to inhibit ACAT1 expression., PMID:38289172
The Role of Chorein Deficiency in Late Spermatogenesis., PMID:38275411
Evidence for hypoxia-induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues., PMID:38265294
Acyl-coenzyme A: cholesterol acyltransferase inhibitor avasimibe suppresses tumorigenesis and induces G1-phase cell-cycle arrest by activating PPARγ signaling pathway in bladder cancer., PMID:38169575
[Clinical phenotypic and genotypic analysis of 5 pediatric patients with β-ketothiolase deficiency]., PMID:38154980
LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis., PMID:38047403
The Identification of Functional Genes Affecting Fat-Related Meat Traits in Meat-Type Pigeons Using Double-Digest Restriction-Associated DNA Sequencing and Molecular Docking Analysis., PMID:37893980
Maturation of lipid metabolism in the fetal and newborn sheep heart., PMID:37867472
Analysis of metabolome and transcriptome of longissimus thoracis and subcutaneous adipose tissues reveals the regulatory mechanism of meat quality in MSTN mutant castrated male finishing pigs., PMID:37864922
Rose polyphenols exert antiobesity effect in high-fat-induced obese mice by regulating lipogenic gene expression., PMID:37757642
Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway., PMID:37582428
[AdipoRon Effect on Expression of Lipid Metabolism Genes in Cultured Human Primary Macrophages]., PMID:37528782
Target Discovery of Matrine against PRRSV in Marc-145 Cells via Activity-Based Protein Profiling., PMID:37511286
For research use only. Not for human or drug use.
