Catalog No.
YHD62901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg165
Predicted molecular weight
20.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24522
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA damage-inducible transcript 1 protein, GADD45, DDIT1, GADD45A, Growth arrest and DNA damage-inducible protein GADD45 alpha, DDIT-1
Marine natural product Methyl mycophenolate inhibits gastric cancer growth through regulating p53 and the downstream pathways., PMID:40484944
Investigating the Genotoxic Potential of Pioglitazone in Hyperglycemic Conditions Using Chromosome Aberration and GADD45α Markers in TK6 Cells., PMID:40465473
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells., PMID:40409732
Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models., PMID:40360172
PTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway., PMID:40305474
GADD45A suppression contributes to cardiac remodeling by promoting inflammation, fibrosis and hypertrophy., PMID:40301189
Machine learning-based transcriptmics analysis reveals BMX, GRB10, and GADD45A as crucial biomarkers and therapeutic targets in sepsis., PMID:40230692
Identification of potential crucial genes and biomarkers from neutrophils in sepsis using bioinformatics analysis., PMID:40184094
Role of SIRT3 in the regulation of Gadd45α expression and DNA repair in β-cells., PMID:40147772
Targeting the TGF-β-p21 axis: a critical regulator of bleomycin-induced cell cycle arrest and apoptosis in vitro-implication for progressive cervical cancer therapy., PMID:40019671
HDAC inhibitors modulate Hippo pathway signaling in hormone positive breast cancer., PMID:40012020
Integrative machine learning model of RNA modifications predict prognosis and treatment response in patients with breast cancer., PMID:39948551
Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc-/GPX4 pathway., PMID:39944356
GADD45α is a direct target of TFEB and contributes to tacrolimus-induced chronic nephrotoxicity., PMID:39913188
Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A., PMID:39908745
Identification of DNA damage repair-related genes in sepsis using bioinformatics and machine learning: An observational study., PMID:39889168
Induction of DNA damage and growth arrest by citalopram in breast cancer cells mediated via activation of Gadd45a and apoptotic genes., PMID:39825580
CircDNA2-Educated YTHDF2 Phase Separation Promotes PM2.5-Induced Malignant Transformation Through the Blunting of GADD45A Expression., PMID:39823477
MicroRNA Screening Reveals Upregulation of FoxO-Signaling in Relapsed Acute Myeloid Leukemia Patients., PMID:39766892
Integration of multi-omics and benchmark dose modeling to support adverse outcome pathways., PMID:39746153
Identification and validation of apoptosis-related genes in acute myocardial infarction based on integrated bioinformatics methods., PMID:39650552
PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A., PMID:39568000
Reversing Zearalenone Toxicity: The Role of Hydroxytyrosol in Zebrafish., PMID:39530315
Nifuratel Induces Triple-Negative Breast Cancer Cell G2/M Phase Block and Apoptosis by Regulating GADD45A., PMID:39458909
NPS-1034 Exerts Therapeutic Efficacy in Renal Cell Carcinoma Through Multiple Targets of MET, AXL, and TNFRSF1A Signaling in a Metastatic Model., PMID:39451232
Investigating the Mechanisms of Anti-tumoral Effect of Combination Therapy of Calcitriol and Sodium Pentaborate Pentahydrate on HepG2 Hepatocellular Carcinoma Cells., PMID:39441231
Citreoviridin induces apoptosis through oxidative damage and inflammatory response in PC-12 cells., PMID:39437026
Comprehensive metabolomics and transcriptomics analyses investigating the regulatory effects of different sources of dietary astaxanthin on the antioxidant and immune functions of commercial-sized rainbow trout., PMID:39391321
Bioinformatics-based Analysis and Verification of Chromatin Regulators and the Mechanism of Immune Infiltration Associated with Myocardial Infarction., PMID:39354722
On the dose-response association of fine and ultrafine particles in an urban atmosphere: toxicological outcomes on bronchial cells at realistic doses of exposure at the Air Liquid Interface., PMID:39349072
Identification of BBC3 as a novel indicator for predicting prostate cancer development and olaparib resistance., PMID:39331229
Aristolochic acids-hijacked p53 promotes liver cancer cell growth by inhibiting ferroptosis., PMID:39090392
Functional evaluation of germline TP53 variants identified in Brazilian families at-risk for Li-Fraumeni syndrome., PMID:39060302
Semaglutide ameliorated autism-like behaviors and DNA repair efficiency in male BTBR mice by recovering DNA repair gene expression., PMID:39032854
Gadd45A-mediated autophagy regulation and its impact on Alzheimer's disease pathogenesis: Deciphering the molecular Nexus., PMID:39004381
Targeting HTR2B suppresses nonfunctioning pituitary adenoma growth and sensitizes cabergoline treatment via inhibiting Gαq/PLC/PKCγ/STAT3 axis., PMID:38989697
GADD45A: a key tumor suppressor in AML subtypes., PMID:38963670
Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway., PMID:38924867
AGEs induce MMP-9 promoter demethylation through the GADD45α-mediated BER pathway to promote breast cancer metastasis in patients with diabetes., PMID:38904412
Silencing of the DNA damage repair regulator PPP1R15A sensitizes acute myeloid leukemia cells to chemotherapy., PMID:38842564
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis., PMID:38834884
METTL1-mediated tRNA m7G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade., PMID:38822363
Neuroinflammation signatures in dorsal root ganglia following chronic constriction injury., PMID:38813203
Evolution of a novel adrenal cell type that promotes parental care., PMID:38750354
Exploring CDKN1A Upregulation Mechanisms: Insights into Cell Cycle Arrest Induced by NC2603 Curcumin Analog in MCF-7 Breast Cancer Cells., PMID:38732206
Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A., PMID:38682208
Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models., PMID:38681131
Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML., PMID:38579286
In vitro suppression of porcine epidemic diarrhea virus by Panax notoginseng saponins: assessing antiviral potential., PMID:38565720
Analysis and experimental validation of IL-17 pathway and key genes as central roles associated with inflammation in hepatic ischemia-reperfusion injury., PMID:38494504
For research use only. Not for human or drug use.
