Catalog No.
YHD62701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro344-Asp497
Predicted molecular weight
20.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24462
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CYP3A7, CYPIIIA7, P450HLp2, Cytochrome P450 3A7, Cytochrome P450-HFLA
Maternal stress and fetoplacental cortisol regulation in small-for-gestational-age newborns., PMID:40344310
The distinctive P450 oxidoreductase (PORD) urinary steroid metabolome in the first week of life: Report of three cases with severe disorder., PMID:40222686
Pharmacogenomics-Based Detection of Variants Involved in Pain, Anti-inflammatory and Immunomodulating Agents Pathways by Whole Exome Sequencing and Deep in Silico Investigations Revealed Novel Chemical Carcinogenesis and Cancer Risks., PMID:40026294
Impact of sex and pregnancy on hepatic CYP3A4 expression and activity in a humanized mouse model., PMID:40023573
DNA Methylation in the CYP3A Distal Regulatory Region (DRR) Is Associated with the Expression of CYP3A5 and CYP3A7 in Human Liver Samples., PMID:39598796
Unveiling dynamic hepatocyte plasticity in HepaRG cells with a dual CYP reporter system., PMID:39527612
Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver., PMID:39284705
When less is more: The association between the expression of polymorphic CYPs and AFB1-induced HCC., PMID:39099542
Fentanyl dosage for preterm infants suggested by a pharmacokinetic, -dynamic, and -genetic model., PMID:39025933
Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling., PMID:38955794
Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5., PMID:38702193
Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function., PMID:38677401
RETRACTED: Exploring the tumor microenvironment: Chemokine-related genes and immunotherapy/chemotherapy response in clear-cell renal cell carcinoma., PMID:38488671
Use of Lentivirus-Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing., PMID:38483112
Research progress regarding CYP3A gene family in gastric cancer., PMID:38448381
[Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities]., PMID:38296497
HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation., PMID:38267095
Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study., PMID:38117080
Cyclic Stretching Enhances Angiocrine Signals at Liver Bud Stage from Human Pluripotent Stem Cells in Two-Dimensional Culture., PMID:38062736
Comparison of 1Beta- and 5Beta-hydroxylation of Deoxycholate and Glycodeoxycholate as In Vitro Index Reactions for Cytochrome P450 3A Activities., PMID:38050044
Stimulatory and Inhibitory Effects of Steroid Hormones and Human Cytochrome P450 (CYP) 3A Inhibitors on Cortisol 6β-Hydroxylation Catalyzed by CYP3A Subfamilies., PMID:37649294
Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam., PMID:37475714
Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate., PMID:37392852
Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates., PMID:36719788
Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement., PMID:36638633
Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5., PMID:36045613
In Vitro Differentiation of Human Amniotic Epithelial Cells into Hepatocyte-like Cells., PMID:35883581
Comparative Study of Binding Pockets in Human CYP1A2, CYP3A4, CYP3A5, and CYP3A7 with Aflatoxin B1, a Hepato-Carcinogen, by Molecular Dynamics Simulation & Principal Component Analysis., PMID:35850656
Cross-ancestry Genome-wide Association Studies of Sex Hormone Concentrations in Pre- and Postmenopausal Women., PMID:35192695
Decoding The Genetic Alterations In Cytochrome P450 Family 3 Genes And Its Association With HNSCC., PMID:35152193
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity., PMID:34989853
Altered Steroidome in Women with Gestational Diabetes Mellitus: Focus on Neuroactive and Immunomodulatory Steroids from the 24th Week of Pregnancy to Labor., PMID:34944390
Variation in Expression of Cytochrome P450 3A Isoforms and Toxicological Effects: Endo- and Exogenous Substances as Regulatory Factors and Substrates., PMID:34719640
Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations., PMID:34689350
CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation., PMID:34688813
Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening., PMID:34593846
Sex-Biased Expression of Pharmacogenes across Human Tissues., PMID:34439872
Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling., PMID:34407992
Mass spectrometry-based targeted proteomics method for the quantification of clinically relevant drug metabolizing enzymes in human specimens., PMID:34390906
OpenCYP: An open source database exploring human variability in activities and frequencies of polymophisms for major cytochrome P-450 isoforms across world populations., PMID:34352333
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density., PMID:34255042
Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population., PMID:34154994
Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evidence for Redifferentiation upon Prolonged Culturing., PMID:34135090
Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7., PMID:34072457
Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template., PMID:33866277
Investigating the Utility of Humanized Pregnane X Receptor-Constitutive Androstane Receptor-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction., PMID:33863817
Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates., PMID:33821626
Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies., PMID:33790108
Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students., PMID:33723203
Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients., PMID:33649515
For research use only. Not for human or drug use.
