Catalog No.
YHD62601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met26-His232
Predicted molecular weight
26.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24394
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-4RA, IL-4-binding protein, IL-4 receptor subunit alpha, Soluble IL-4R-alpha, IL4-BP, IL4R, IL-4R subunit alpha, IL-4R-alpha, CD124, Interleukin-4 receptor subunit alpha, IL4RA, Soluble IL-4 receptor subunit alpha, sIL4Ralpha/prot
Interleukin-4 and its receptor alpha in paediatric uncomplicated malaria patients from a Ghanaian case-control study., PMID:39482779
Dupilumab: Mechanism of action, clinical, and translational science., PMID:39080841
Long non-coding RNA LBX2-AS1 activates IL4R to promote glioblastoma metastasis and angiogenesis by binding to the transcription factor NFKB1., PMID:39045789
Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor., PMID:38935626
A novel inhalable nanobody targeting IL-4Rα for the treatment of asthma., PMID:38871183
IL-4Rα signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease., PMID:38704098
CD44v5 domain regulates crosstalk between TNBC cells and tumor-associated macrophages by enhancing the IL-4R/STAT3 axis., PMID:38700108
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps., PMID:38603825
Associations between interleukin-13, interleukin-4 and their receptor gene polymorphisms and susceptibility to atopic dermatitis in a Chinese Han population., PMID:38594991
Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans., PMID:38426866
Anti-cancer activity of microbubble conjugated with Sorafenib containing liposome and IL4R-targeting peptide in kidney cancer cells., PMID:38279420
Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling., PMID:38081297
Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle., PMID:37933466
Rademikibart (CBP-201), a next-generation monoclonal antibody targeting human IL-4Rα: Two phase I randomized trials, in healthy individuals and patients with atopic dermatitis., PMID:37849431
Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis., PMID:37565285
Association of IL4RA polymorphism in predicting susceptibility toward chronic obstructive pulmonary disease., PMID:37551548
Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer., PMID:37117331
Dupilumab but not cyclosporine treatment shifts the microbiome toward a healthy skin flora in patients with moderate-to-severe atopic dermatitis., PMID:37032440
IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases., PMID:36445014
Interleukin-3 stabilizes CD124/IL-4α surface expression in mast cells via Tyk2 and STAT6., PMID:36440951
Atopic Dermatitis Mediates the Association Between an IL4RA Variant and Food Allergy in School-Aged Children., PMID:35589010
CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer., PMID:34922544
M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages., PMID:34560422
Interleukin 4 and Interleukin 4 receptor alpha gene variants and risk of atopy - A case control study based assessment., PMID:34129931
Associations of interleukin-4 and interleukin-4 receptor loci with esophageal squamous cell carcinoma susceptibility., PMID:33895482
RNA-Seq Identifies Marked Th17 Cell Activation and Altered CFTR Expression in Different Atopic Dermatitis Subtypes in Chinese Han Populations., PMID:33868246
GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals., PMID:33864772
Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma., PMID:33863808
Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children., PMID:33861987
Therapeutic targeting with DABIL-4 depletes myeloid suppressor cells in 4T1 triple-negative breast cancer model., PMID:33682324
Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis., PMID:33610558
In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump., PMID:33581123
Molecular mechanism of asthma and its novel molecular target therapeutic agent., PMID:33549541
Human marginal zone B cell development from early T2 progenitors., PMID:33538776
IL4RA gene expression in relation to I50V, Q551R and C-3223T polymorphisms., PMID:33529503
Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade., PMID:33483337
Expression of IL4Rα and IL13Rα1 are associated with poor prognosis of soft-tissue sarcoma of the extremities, superficial trunk, and retroperitoneum., PMID:33419470
Detection of association of IL1β, IL4R, and IL6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetra-primer ARMS-PCR method., PMID:33187912
Biologics for Atopic Dermatitis., PMID:33012322
Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis., PMID:33012318
Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population., PMID:32902809
Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor., PMID:32881535
Anti-VCAM-1 and Anti-IL4Rα Aptamer-Conjugated Super Paramagnetic Iron Oxide Nanoparticles for Enhanced Breast Cancer Diagnosis and Therapy., PMID:32751068
Genetic variants in IL4RA, IL6, and IL12B genes and susceptibility to hepatitis B and C virus infections among Iraqi patients., PMID:32652594
Immunohistochemical Characterization of the IL-13:IL-4 Receptor α Axis in the Skin of Adult Patients with Moderate to Severe Atopic Dermatitis and Healthy Controls., PMID:32598926
Assessing the risk of dupilumab use for atopic dermatitis during the COVID-19 pandemic., PMID:32534081
Onset of Schamberg Disease and Resolution of Alopecia Areata During Treatment of Atopic Dermatitis With Dupilumab., PMID:32490817
Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells., PMID:32315671
IL-4R is expressed on alpha and beta cells of human pancreata., PMID:32224156
Further insights into the evolution of starch assembly during retrogradation using SAXS., PMID:32194108
For research use only. Not for human or drug use.
