Catalog No.
YHD62401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr25-Leu322
Predicted molecular weight
35.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24387
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CRH-BP, CRFBP, CRHBP, Corticotropin-releasing hormone-binding protein, CRF-binding protein, CRF-BP, Corticotropin-releasing factor-binding protein
Predator odor stress produces sex- and subpopulation-specific increases in alcohol drinking, anxiety-like behavior, and lateral hypothalamic Crh expression., PMID:40374160
Increased CRF-R1 transmission in the nucleus accumbens shell facilitates maternal neglect in lactating rats and mediates anxiety-like behaviour in a sex-specific manner., PMID:39647775
CRHBP, a novel multiple cancer biomarker connected with better prognosis and anti-tumorigenicity., PMID:39614295
Therapeutic targets for gastrointestinal diseases: proteome-wide Mendelian randomization and colocalization analyses., PMID:39400547
A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease., PMID:39303715
Epigenetic molecular underpinnings of brain structural-functional connectivity decoupling in patients with major depressive disorder., PMID:39029702
A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells., PMID:38879647
Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma., PMID:38608145
CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats., PMID:38601362
Response of CRH system in brain and gill of marine medaka to seawater acidification., PMID:38512395
A pan-cancer analysis uncovering the function of CRHBP in tumor immunity, prognosis and drug response: especially its function in LIHC., PMID:38326407
Temperature- and genotype-dependent stress response and activation of the hypothalamus-pituitary-interrenal axis during temperature-induced sex reversal in pejerrey Odontesthes bonariensis, a species with genotypic and environmental sex determination., PMID:38008372
Crucial role of corticotropin-releasing hormone, corticotropin-releasing hormone -binding protein, mir-200c, and mir-181a in preterm delivery: A case-control study., PMID:37969569
Downregulation of CRHBP is associated with trophoblast invasion inhibition in recurrent pregnancy loss., PMID:37947291
A whole exome sequencing study to identify rare variants in multiplex families with alcohol use disorder., PMID:37915799
The exploration of neuroinflammatory mechanism by which CRHR2 deficiency induced anxiety disorder., PMID:37640149
Early life stage exposure to cadmium and zinc within hour affected GH/IGF axis, Nrf2 signaling and HPI axis in unexposed offspring of marine medaka Oryzias melastigma., PMID:37451186
DNA Methylation of Genes Involved in the HPA Axis in Presence of Suicide Behavior: A Systematic Review., PMID:37190549
CpG Methylation Levels in HPA Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure., PMID:36906051
Discovering new peripheral plasma biomarkers to identify cognitive decline in type 2 diabetes., PMID:36506101
Characterization of CRH-Binding Protein (CRHBP) in Chickens: Molecular Cloning, Tissue Distribution and Investigation of Its Role as a Negative Feedback Regulator within the Hypothalamus-Pituitary-Adrenal Axis., PMID:36292565
Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease., PMID:36280595
Organization of the corticotropin-releasing hormone and corticotropin-releasing hormone-binding protein systems in the central nervous system of the sea lamprey Petromyzon marinus., PMID:36150899
The Effect of CRHBP rs10062367 Polymorphism and Parenting Styles on Internalizing Problems in Preschoolers: The Moderating Effect of Sensory Processing Sensitivity., PMID:36114994
The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata)., PMID:35872527
Adrenal insufficiency in pregnancy: Physiology, diagnosis, management and areas for future research., PMID:35816262
Potential Biomarkers and Drugs for Nanoparticle-Induced Cytotoxicity in the Retina: Based on Regulation of Inflammatory and Apoptotic Genes., PMID:35565057
CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex., PMID:35082401
Single-cell RNA-sequencing analysis of the ciliary epithelium and contiguous tissues in the mouse eye., PMID:34717927
Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report., PMID:34229186
DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake., PMID:33784941
Distress Regulates Different Pathways in the Brain of Common Carp: A Preliminary Study., PMID:33672436
[Analysis of Correlation between Gene Polymorphisms of CRHBP in Yunnan Han Population and Schizophrenia and Aggressive Behavior]., PMID:33295169
Polymorphisms in Stress-Related Genes Are Associated with Reduced Cocaine Abuse and Longer Retention in Methadone Maintenance Treatment for Opioid Use Disorder., PMID:33242852
Influence and interaction of genetic, cognitive, neuroendocrine and personalistic markers to antidepressant response in Chinese patients with major depression., PMID:32702381
The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for Robbery Behavior Among the Han Chinese., PMID:32551975
Cancer-Specific Loss of Urocortin 3 in Human Renal Cancer., PMID:31721113
Integrative analysis reveals CRHBP inhibits renal cell carcinoma progression by regulating inflammation and apoptosis., PMID:31570754
Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma., PMID:31277598
Environmental Cycles, Melatonin, and Circadian Control of Stress Response in Fish., PMID:31244768
Association of childhood trauma and genetic variability of CRH-BP and FKBP5 genes with suicidal behavior in bipolar patients., PMID:31195252
Aroclor 1254 inhibits vasotocinergic pathways related to osmoregulatory and stress functions in the gilthead sea bream (Sparus aurata, Linnaeus 1758)., PMID:31082703
Arginine Vasotocin and Cortisol Co-regulate Vasotocinergic, Isotocinergic, Stress, and Thyroid Pathways in the Gilthead Sea Bream (Sparus aurata)., PMID:30949066
Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction., PMID:30844877
Genetic Variants and the Cortisol Response in Children: An Exploratory Study., PMID:30700110
Constitutive Serotonin Transporter Reduction Resembles Maternal Separation with Regard to Stress-Related Gene Expression., PMID:30614673
Polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis and antidepressant response - Systematic review., PMID:30465786
HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females., PMID:30319260
Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma., PMID:30127978
Association between stress pathway gene (CRHR1⧹CRHBP) polymorphisms and heroin dependence., PMID:29853227
For research use only. Not for human or drug use.
