Catalog No.
RHG52103
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Ikaros family zinc finger protein 1, LYF1, ZNFN1A1, DNA-binding protein Ikaros, IKAROS, Lymphoid transcription factor LyF-1, IKZF1, IK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13422
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S46
Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab., PMID:40369607
Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging., PMID:40366697
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Rare genetic variants provide a mechanistic basis for immune imbalance in IgG4-related disease., PMID:39145453
Targeting Ikaros and Aiolos: reviewing novel protein degraders for the treatment of multiple myeloma, with a focus on iberdomide and mezigdomide., PMID:39054911
LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway., PMID:39025844
Activation of Wnt/β-catenin signaling promotes immune evasion via the β-catenin/IKZF1/CCL5 axis in hepatocellular carcinoma., PMID:38941667
How to Manage Philadelphia-Positive Acute Lymphoblastic Leukemia in Resource-Constrained Settings., PMID:38136329
Long-Term Results of the Dasatinib-Blinatumomab Protocol for Adult Philadelphia-Positive ALL., PMID:38127722
Genetic alterations and MRD refine risk assessment for KMT2A-rearranged B-cell precursor ALL in adults: a GRAALL study., PMID:37595275
Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions., PMID:35650277
Drug resistance and minimal residual disease in multiple myeloma., PMID:35582527
An autologous culture model of nodal B-cell lymphoma identifies ex vivo determinants of response to bispecific antibodies., PMID:34587238
Pyrotinib combined with thalidomide in advanced non-small-cell lung cancer patients harboring HER2 exon 20 insertions (PRIDE): protocol of an open-label, single-arm phase II trial., PMID:34530760
Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance., PMID:34505882
Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia., PMID:34501239
There is no gene for CVID - novel monogenetic causes for primary antibody deficiency., PMID:34153571
Establishment and validation of immune microenvironmental gene signatures for predicting prognosis in patients with head and neck squamous cell carcinoma., PMID:34091115
Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia., PMID:34062932
Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus., PMID:33727237
A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice., PMID:33658297
IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK., PMID:33623139
The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages., PMID:33563611
Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children-a novel health disparity., PMID:33531655
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis., PMID:33531346
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia., PMID:33400146
Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4., PMID:33357426
Cutaneous IgA vasculitis-presenting manifestation of a novel mutation in the IKZF1 gene., PMID:33097959
Dasatinib-Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults., PMID:33085860
IKAROS Family Zinc Finger 1-Associated Diseases in Primary Immunodeficiency Patients., PMID:32654692
Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide., PMID:32591583
Management of Chronic Immune Thrombocytopenia and Presumed Autoimmune Hepatitis in a Child with IKAROS Haploinsufficiency., PMID:32319000
Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases., PMID:32128391
Rapid and deep-scale ubiquitylation profiling for biology and translational research., PMID:31953384
Characterization of novel, recurrent genomic rearrangements as sensitive MRD targets in childhood B-cell precursor ALL., PMID:31784504
Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7., PMID:31358854
Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia., PMID:31299112
Immunomodulatory drugs in the treatment of multiple myeloma., PMID:31187860
Defining the genetic control of human blood plasma N-glycome using genome-wide association study., PMID:31163085
Polymorphisms in MAPK9 (rs4147385) and CSF1R (rs17725712) are associated with the development of inhibitors in patients with haemophilia A in North China., PMID:31149782
IKZF1 Loss-of-Function Variant Causes Autoimmunity and Severe Familial Antiphospholipid Syndrome., PMID:31089937
Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency., PMID:31057532
Multiple myeloma immunoglobulin lambda translocations portend poor prognosis., PMID:31015454
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos., PMID:30228232
Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease., PMID:29991969
IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy., PMID:29960886
Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus., PMID:29945920
[New and traditional directions in the biology and management of childhood acute lymphoblastic leukemia]., PMID:29754509
A kindred with mutant IKAROS and autoimmunity., PMID:29705243
Myeloma Cells Are Activated in Bone Marrow Microenvironment by the CD180/MD-1 Complex, Which Senses Lipopolysaccharide., PMID:29363546
For research use only. Not for human or drug use.
