Catalog No.
YHD59101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr432
Predicted molecular weight
50.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23526
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAHH, AHCY, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, Adenosylhomocysteinase
IRBITs, signaling molecules of great functional diversity., PMID:40445299
Renal Dysfunction Induced by Sodium p-Perfluorous Nonenoxybenzenesulfonate in Mice: Insights from the Intrinsic Mechanisms of Proteinuria., PMID:40444664
Methionine cycle inhibition disrupts antioxidant metabolism and reduces glioblastoma cell survival., PMID:40015640
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT., PMID:39985648
Transcriptional changes impact hepatic proteome in autophagy-impaired liver., PMID:39284785
The role of S-adenosylhomocysteine hydrolase-like 1 in cancer., PMID:39154900
Protein Thermal Stability Changes Induced by the Global Methylation Inhibitor 3-Deazaneplanocin A (DZNep)., PMID:39062531
Network pharmacology and molecular docking technology for exploring the effect and mechanism of high-dose vitamin c on ferroptosis of tumor cells: A review., PMID:38758839
Differential responses of selectively bred mussels (Perna canaliculus) to heat stress-survival, immunology, gene expression and microbiome diversity., PMID:38425477
Profiling the genome and proteome of metabolic dysfunction-associated steatotic liver disease identifies potential therapeutic targets., PMID:38076879
Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells., PMID:38064408
SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model., PMID:38052822
Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways., PMID:38052817
Adenosylhomocysteinase plays multiple roles in maintaining the identity and pluripotency of mouse embryonic stem cells†., PMID:38035769
Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells., PMID:38003292
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1., PMID:37951201
Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution., PMID:37824452
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target., PMID:37580540
Study on the Mechanism of MC5R Participating in Energy Metabolism of Goose Liver., PMID:37239994
Exosomal circ-AHCY promotes glioblastoma cell growth via Wnt/β-catenin signaling pathway., PMID:37150844
Chromatin access regulates the formation of Müller glia-derived progenitor cells in the retina., PMID:36971459
Identification of novel immune subtypes and potential hub genes of patients with psoriasis., PMID:36890558
Discovery of AHCY as an Off-Target of Doxorubicin by Integrative Analysis of Photoaffinity Labeling Chemoproteomics and Untargeted Metabolomics., PMID:36445716
3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice., PMID:36438588
MGL S3 Chimeric Enzyme Drives Apoptotic Death of EGFR-Dependent Cancer Cells through ERK Downregulation., PMID:36361596
Evidence from transcriptome analysis unravelled the roles of eyestalk in salinity adaptation in Pacific white shrimp (Litopenaeus vannamei)., PMID:36055397
Wumei Pill Ameliorates AOM/DSS-Induced Colitis-Associated Colon Cancer through Inhibition of Inflammation and Oxidative Stress by Regulating S-Adenosylhomocysteine Hydrolase- (AHCY-) Mediated Hedgehog Signaling in Mice., PMID:35927991
Bioinformatics role of the WGCNA analysis and co-expression network identifies of prognostic marker in lung cancer., PMID:35844396
Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases., PMID:35833542
A heterotypic assembly mechanism regulates CHIP E3 ligase activity., PMID:35762422
RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1., PMID:35562179
Identification and Characterization of a Glucometabolic Prognostic Gene Signature in Neuroblastoma based on N6-methyladenosine Eraser ALKBH5., PMID:35517412
NF-κB-Related Metabolic Gene Signature Predicts the Prognosis and Immunotherapy Response in Gastric Cancer., PMID:35036435
Screening and cellular validation of prognostic genes regulated by super enhancers in oral squamous cell carcinoma., PMID:34709988
Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation., PMID:34348140
Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach., PMID:34326469
In silico-driven analysis of the Glossina morsitans morsitans antennae transcriptome in response to repellent or attractant compounds., PMID:34249514
AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner., PMID:33993848
Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening., PMID:33915303
Interaction analysis of gene variants related to one-carbon metabolism with chronic hepatitis B infection in Chinese patients., PMID:33894044
Coordinated expression of Jumonji and AHCY under OCT transcription factor control to regulate gene methylation in wood frogs during anoxia., PMID:33887369
Functional and Pathological Roles of AHCY., PMID:33869213
Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer., PMID:33753854
Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2., PMID:33727633
A comprehensive association analysis between homocysteine metabolic pathway gene methylation and ischemic stroke in a Chinese hypertensive population., PMID:33382484
S-adenosyl-l-homocysteine Hydrolase: A Structural Perspective on the Enzyme with Two Rossmann-Fold Domains., PMID:33339190
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling., PMID:33328229
The values of AHCY and CBS promoter methylation on the diagnosis of cerebral infarction in Chinese Han population., PMID:33138824
3-Deazaadenosine, an S-adenosylhomocysteine hydrolase inhibitor, attenuates lipopolysaccharide-induced inflammatory responses via inhibition of AP-1 and NF-κB signaling., PMID:33035507
ITRAQ Proteomic Analysis of Yellow and Black Skin in Jinbian Carp (Cyprinus carpio)., PMID:33007994
For research use only. Not for human or drug use.
