Catalog No.
YHD57901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro32-Phe286
Predicted molecular weight
32.06 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23458
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
JAK1B, JAK1, Janus kinase 1, Tyrosine-protein kinase JAK1, JAK1A, JAK-1
Recombinant protein TprK promotes M1 macrophage polarization and phagocytosis by inducing Indoleamine 2,3-dioxygenase protein production., PMID:40513619
Expression of PIM1/ASK1 Molecular Pathway Related Genes in Ischemic Cardiomyopathy., PMID:40511800
Phytochemical Characterization, Antioxidant Activity, and Anti-Melanoma Mechanism of Flower Buds of Magnolia biondii Pamp., PMID:40508400
Mouse Th2 cell extracellular vesicles promote eosinophil survival through the surface cytokine cargo IL-3., PMID:40505836
Crosstalk Between Th17 Cells and Renal Tubular Epithelial Cells Promotes Fibrotic Progression in IgA Nephropathy., PMID:40498423
Upadacitinib for refractory Behçet's disease with myelodysplastic syndrome and trisomy 8/9: a case report and mechanistic insights., PMID:40496858
Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1-STAT3 signaling., PMID:40496853
Thyroid hormones contribute to JAK/STAT pathway abnormal activation promoting T-cell lymphoma dissemination., PMID:40489893
Involvement of IL-6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate., PMID:40488252
The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing IL20RB., PMID:40460193
Dabrafenib stimulates autophagy in thyroid carcinoma cells via HMGB-1., PMID:40451856
Pharmacophore Modeling of Janus Kinase Inhibitors: Tools for Drug Discovery and Exposition Prediction., PMID:40430355
CD44 Marks Dormant Tumor Cells After HER2 Inhibition in Breast Cancer Cells., PMID:40430044
Baricitinib and Lonafarnib Synergistically Target Progerin and Inflammation, Improving Lifespan and Health in Progeria Mice., PMID:40429989
The Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of Orally Dosed QY201, a Novel JAK1/TYK2 Inhibitor, in Chinese Healthy Subjects., PMID:40424417
Efficacy of JAK1/2 inhibition in murine myeloproliferative neoplasms is not mediated by targeting oncogenic signaling., PMID:40413183
Glucocorticoid reduces mortality in LPS-induced sepsis mouse model by inhibiting JAK1/STAT3-mediated inflammatory response and restoring tricarboxylic acid cycle., PMID:40408938
Momelotinib - a tale of trials, tribulations, transfusion independence, and triumph., PMID:40405506
Trimetazidine improves dexamethasone-induced insulin resistance and associated hepatic abnormalities in rats., PMID:40404121
JAK1/2 Inhibitors Alleviate the Damage of Intercellular Adhesion by Reducing Endoplasmic Reticulum Stress-Induced Apoptosis in Pemphigus Vulgaris., PMID:40392073
Selective JAK-1 inhibitor Upadacitinib and peptide PD29 modulate the JAK and TGF-β/Smad signaling pathways reducing experimental dermal fibrosis., PMID:40381666
Pentagalloyl glucose targets the JAK1/JAK3-STAT3 pathway to inhibit cancer stem cells and epithelial-mesenchymal transition in 5-fluorouracil-resistant colorectal cancer., PMID:40378534
Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer., PMID:40374882
IFN-γ-mediated suppression of ANGPT2-Tie2 in endothelial cells facilitates tumor vascular normalization during immunotherapy., PMID:40370455
OASL activates MAPK to drive psoriatic pathogenesis: Astilbin targeting this axis improves metabolic-inflammation crosstalk., PMID:40360089
Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells., PMID:40351125
Exosomes derived from African swine fever virus-infected pigs mediate immune responses through NF-κB and JAK-STAT signaling pathways., PMID:40347599
Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes., PMID:40346694
High-Frequency Mutations in TP53, AXIN1, CTNNB1, and KRAS, and Polymorphisms in JAK1 Genes Among Mongolian HCC Patients., PMID:40344393
The JAK1/STAT3 pathway mediates the effects of SERPINH1 on glioma EMT., PMID:40334628
Genetic Variants in the NOD-like Receptor Signaling Pathway Are Associated with HIV-1/AIDS in a Northern Chinese Population., PMID:40331958
Is Upadacitinib Cardioprotective in Chronic Inflammatory Diseases? A Review of Major Adverse Cardiovascular Events and Venous Thromboembolism in Atopic Dermatitis., PMID:40327575
Luteolin: A potential therapeutic agent for respiratory diseases., PMID:40324574
Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism., PMID:40320905
Atopic dermatitis relapse after treatment discontinuation and predictive factors for relapse: JAK1 inhibitors versus dupilumab., PMID:40317605
Xin Sheng Hua Granule ameliorate chemotherapy-induced blood deficiency syndrome through ihibiting JAK1/STAT1 pathway activation., PMID:40316148
Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway., PMID:40312752
Tofacitinib as a promising treatment for refractory erythroderma-like Hailey-Hailey disease., PMID:40298163
Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancer., PMID:40298145
Molecular characterization, expression, evolutionary analysis and molecular docking of the Janus activated kinase family members of largemouth bass (Micropterus salmoides)., PMID:40288622
Ruxolitinib Ameliorates Neuronal Pyroptosis in the Acute Phase of Intracerebral Hemorrhage through Inhibiting the Activation of Caspase-8., PMID:40286335
The blood transcriptome of musk deer under heat stress condition reveals the regulatory mechanism of genes to maintain homeostasis metabolism., PMID:40275126
L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway., PMID:40267722
Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration., PMID:40266594
LDHA-lactate axis modulates mitophagy inhibiting CSFV replication., PMID:40265937
Retraction Note: Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in hepatitis C virus replicon., PMID:40253341
Loss of lims1 causes aberrant cardiac remodeling and heart failure via activating gp130/Jak1/Stat3 pathway in zebrafish., PMID:40252966
Polycythaemia vera., PMID:40246933
IL-17 enhanced the susceptibility to fluoxetine resistance in depression via the JAK1-STAT6 signaling pathway., PMID:40233450
IFN-γ-Induced intestinal epithelial cell-type-specific programmed cell death: PANoptosis and its modulation in Crohn's disease., PMID:40230837
For research use only. Not for human or drug use.
