Catalog No.
YHD52701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala361-Ala587
Predicted molecular weight
27.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22557
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
5-aminolevulinate synthase, erythroid-specific, mitochondrial, ALAS2, ASB, ALAS-E, ALASE, Delta-ALA synthase 2, Delta-aminolevulinate synthase 2, 5-aminolevulinic acid synthase 2
Molecular basis identification and hypnotic drug interactions for cognitive impairment related to sleep deprivation., PMID:40229714
The role of genetic testing in accurate diagnosis of X-linked sideroblastic anemia: novel ALAS2 mutations and the impact of X-chromosome inactivation., PMID:40195342
Integrated Bioinformatics Analysis Revealing that the NSDHL Gene Might Be Associated with the Progression of Western HFD/SW-Induced Hepatocellular Carcinoma., PMID:40033501
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study., PMID:40017630
Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the ALAS2 gene leading to X-linked sideroblastic anemia-a family study., PMID:39995829
X-linked sideroblastic anemia in females., PMID:39912603
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing., PMID:39700288
SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains., PMID:39468120
Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system., PMID:39462081
Comparison between standard hematological parameters and blood doping biomarkers in dried blood spots within the athlete population of Swiss Sport Integrity., PMID:39364095
[Pathophysiology of sideroblastic anemia]., PMID:39358290
ANK1 inhibits malignant progression of osteosarcoma by promoting ferroptosis., PMID:39217322
Key Genes FECH and ALAS2 under Acute High-Altitude Exposure: A Gene Expression and Network Analysis Based on Expression Profile Data., PMID:39202434
Non-syndromic congenital sideroblastic anaemia; phenotype, and genotype of 15 Indian patients., PMID:39196378
Rapid detection of blood using a novel application of RT-RPA integrated with CRISPR-Cas: ALAS2 detection as a model., PMID:39089060
Murine models of erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine., PMID:38900972
Elucidating the Role of Human ALAS2 C-terminal Mutations Resulting in Loss of Function and Disease., PMID:38888931
Update on heme biosynthesis, tissue-specific regulation, heme transport, relation to iron metabolism and cellular energy., PMID:38888238
GPS2 promotes erythroid differentiation in K562 erythroleukemia cells primarily via NCOR1., PMID:38814500
ALAS2 overexpression alleviates oxidative stress-induced ferroptosis in aortic aneurysms via GATA1 activation., PMID:38738239
mRNA biomarkers sensitive and specific to micro-dose erythropoietin treatment at sea level and altitude., PMID:38382494
Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting., PMID:38360212
Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1., PMID:38269509
Luspatercept for the treatment of congenital sideroblastic anemia: Two case reports., PMID:38244303
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease., PMID:38133636
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia., PMID:38053370
Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish., PMID:38040044
Harnessing large language models (LLMs) for candidate gene prioritization and selection., PMID:37845713
Single-cell RNA seq analysis of erythroid cells reveals a specific sub-population of stress erythroid progenitors., PMID:37791839
Diagnostic yield of targeted next-generation sequencing for pediatric hereditary hemolytic anemia., PMID:37697358
A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice., PMID:37491335
Dysregulation of Iron Metabolism-Linked Genes at Myocardial Tissue and Cell Levels in Dilated Cardiomyopathy., PMID:36769209
Novel insights into the immune cell landscape and gene signatures in autism spectrum disorder by bioinformatics and clinical analysis., PMID:36761165
Allogenic Hematopoietic Stem Cell Transplant in Iranian Patients With Congenital Sideroblastic Anemia: A Single-Center Experience., PMID:36757170
Case report: An infant boy with X-linked sideroblastic anaemia successfully treated by umbilical cord blood haematopoietic stem cell transplantation., PMID:36457748
A pilot study of oral iron therapy in erythropoietic protoporphyria and X-linked protoporphyria., PMID:36406817
The effects of iron injection on blood doping biomarkers in dried blood spots., PMID:36354188
METTL3-modified lncRNA-SNHG8 binds to PTBP1 to regulate ALAS2 expression to increase oxidative stress and promote myocardial infarction., PMID:36282350
Exposure to a mixture of per-and polyfluoroalkyl substances modulates pulmonary expression of ACE2 and circulating hormones and cytokines., PMID:36270329
Transcriptome and metabolome analyses reveal the interweaving of immune response and metabolic regulation in pelvic organ prolapse., PMID:36136109
ANTXR1 Regulates Erythroid Cell Proliferation and Differentiation through wnt/β-Catenin Signaling Pathway In Vitro and in Hematopoietic Stem Cell., PMID:36065334
Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome., PMID:36028755
A Bioinformatics Study of Ropivacaine plus Dexamethasone Prolonging the Duration of Nerve Block., PMID:35990127
The estimation of bloodstain age utilizing circRNAs and mRNAs biomarkers., PMID:35901585
Mitochondrial Respiration in Peripheral Blood Mononuclear Cells Negatively Correlates with Disease Severity in Pulmonary Arterial Hypertension., PMID:35887896
ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation., PMID:35714932
Integrated bioinformatics analysis reveals marker genes and immune infiltration for pulmonary arterial hypertension., PMID:35710932
Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis., PMID:35637209
Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study., PMID:35176998
Structural basis for dysregulation of aminolevulinic acid synthase in human disease., PMID:35093382
For research use only. Not for human or drug use.
