Catalog No.
YHD47401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala22-Asp143
Predicted molecular weight
15.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21741
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Amphiregulin-associated protein, Midgestation and kidney protein, NEGF2, MDK, ARAP, MK1, Neurite outgrowth-promoting factor 2, MK, Midkine, Neurite outgrowth-promoting protein
Brain Region-specific Accumulation of Amyloidosis-associated Proteins in Postmortem Brain Tissues of Alzheimer's Disease Patients., PMID:40502767
Dissecting the endothelial cell landscape in meningioma: single-cell insights into PLVAP+ subpopulations and their role in tumor angiogenesis., PMID:40496867
Targeting the MDK/c-Myc complex to overcome temozolomide resistance in glioma., PMID:40468625
Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing., PMID:40441854
Significance of Midkine Signaling in Women's Cancers: Novel Biomarker and Therapeutic Target., PMID:40429950
Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway's role in shaping the immunosuppressive environment of lung adenocarcinoma., PMID:40396179
A novel pH-sensitive nanoparticles encapsulating anti-PD-1 antibody and MDK-siRNA overcome immune checkpoint blockade resistance in HCC via reshaping immunosuppressive TME., PMID:40380202
Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study., PMID:40374689
Single-Cell Transcriptomic Analysis of the Potential Mechanisms of Follicular Development in Stra8-Deficient Mice., PMID:40332359
The combination of midkine inhibitor with Lenvatinib amplifies the suppression of hepatocellular carcinoma., PMID:40321061
Emerging regulators of gastric cancer angiogenesis: Synergistic effects of regulator of G protein signaling 4 and midkine., PMID:40260064
Current Advancements in Serum Protein Biomarkers for Hepatitis B Virus-Associated Hepatocyte Remodeling and Hepatocellular Carcinoma., PMID:40192058
Phenotypic spectrum and theoretical prime editing analysis of WDR19-mediated retinal degeneration., PMID:40183892
Midkine Attenuates Aβ Fibril Assembly and Amyloid Plaque Formation., PMID:40166321
Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade., PMID:40155713
Replacing Animal Meat with Plant-Based Meat Alternatives: The Impact of Protein Quality on Protein Adequacy in the Dutch Diet., PMID:40125476
A comprehensive analysis of scRNA-Seq and RNA-Seq unveils B cell immune suppression in the AAV-loaded brain., PMID:40044925
Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer., PMID:39955556
Midkine-a interacts with Ptprz1b to regulate neural plate convergence and midline formation in the developing zebrafish hindbrain., PMID:39924070
Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma., PMID:39908652
Whole-genome sequencing identified ALK as a novel susceptible gene of Hirschsprung disease., PMID:39765391
Hemophilia B Leyden: characteristics and natural history in the International Pediatric Network of Hemophilia Management Registry., PMID:39742973
TMEM101 expression and its impact on immune cell infiltration and prognosis in hepatocellular carcinoma., PMID:39738479
Midkine promotes thyroid cancer cell migration and invasion by activating the phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin pathway., PMID:39737135
The significance of MDK growth factor in the antler development of sika deer (Cervus nippon): An in-depth analysis., PMID:39733918
Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccines (the PSERENADE project): a global surveillance analysis., PMID:39706205
Global impact of ten-valent and 13-valent pneumococcal conjugate vaccines on invasive pneumococcal disease in all ages (the PSERENADE project): a global surveillance analysis., PMID:39706204
Ceftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections., PMID:39614972
Midkine at the Crossroads of Aging and Cancer., PMID:39570794
Aged hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment., PMID:39540334
An oriented self-assembly biosensor with built-in error-checking for precise midkine detection in cancer diagnosis and prognosis evaluation., PMID:39504885
Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma., PMID:39473957
Bioinformatics study of bortezomib resistance-related proteins and signaling pathways in mantle cell lymphoma., PMID:39430832
Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB., PMID:39408697
Heparin-enriched plasma proteome is significantly altered in Alzheimer's disease., PMID:39380021
Midkine as a driver of age-related changes and increase in mammary tumorigenesis., PMID:39366375
Midkine is upregulated in the hippocampus following both spatial and olfactory reward association learning and enhances memory., PMID:39361112
Diagnostic value of Midkine and AFP in the detection of hepatocellular carcinoma: A systematic review and meta-analysis., PMID:39359432
The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer., PMID:39349474
Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus., PMID:39334352
BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma., PMID:39300217
Midkine: A Cancer Biomarker Candidate and Innovative Therapeutic Approaches., PMID:39257008
Resorbable Microspheres versus Trisacryl Gelatin Microspheres for Uterine Artery Embolization: A Randomized Controlled Trial., PMID:39254451
Machine learning approach to predict blood-secretory proteins and potential biomarkers for liver cancer using omics data., PMID:39216516
Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer., PMID:39191496
Angelica sinensis polysaccharide facilitates chondrogenic differentiation of adipose-derived stem cells via MDK-PI3K/AKT signaling cascade., PMID:39191028
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease., PMID:39127040
The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response., PMID:39123229
Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC., PMID:39116206
Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn., PMID:39115062
For research use only. Not for human or drug use.
