Catalog No.
YHD42001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln32-Arg178
Predicted molecular weight
19.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20800
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Preproendothelin-2, PPET2, Endothelin-2, EDN2, ET-2
APOE mediates the coupling of myogenesis and lipid metabolism in skeletal muscle: decoding intercellular crosstalk via a cell co-culture model., PMID:40409627
Granulosa cell expression of Fos is critical for regulating ovulatory gene expressions in the mouse ovary., PMID:39945297
Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study., PMID:39586851
Acute Amelioration of Inflammatory Activity Caused by Endothelin-2 Deficiency during Acute Lung Injury., PMID:37941117
Application of spatial transcriptomics analysis using the Visium system for the mouse nasal cavity after intranasal vaccination., PMID:37545501
RNA-Seq Analysis Reveals an Essential Role of the cGMP-PKG-MAPK Pathways in Retinal Degeneration Caused by Cep250 Deficiency., PMID:37240188
Endothelin receptor B enhances liver injury and pro-inflammatory responses by increasing G-protein-coupled receptor kinase-2 expression in primary biliary cholangitis., PMID:36396948
A novel missense variant in endothelin-2 (EDN2) causes a growth and respiratory lethal syndrome in bovine., PMID:35912509
Spatiotemporal MicroRNA-Gene Expression Network Related to Orofacial Clefts., PMID:35774010
Endothelin 2: a key player in ovulation and fertility., PMID:35167488
Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina., PMID:34664634
Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women., PMID:34360981
PLXNC1: A Novel Potential Immune-Related Target for Stomach Adenocarcinoma., PMID:34277610
High-fat diet induces an ovulatory defect associated with dysregulated endothelin-2 in mice., PMID:33428588
Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications†., PMID:33112382
The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population., PMID:32881967
A putative silencer variant in a spontaneous canine model of retinitis pigmentosa., PMID:32150541
Cd9 Protects Photoreceptors from Injury and Potentiates Edn2 Expression., PMID:32150249
Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor., PMID:31979254
MicroRNA-124 Enhances Dopamine Receptor Expression and Neuronal Proliferation in Mouse Models of Parkinson's Disease via the Hedgehog Signaling Pathway by Targeting EDN2., PMID:31454817
Hypoxia Limits the Growth of Bovine Follicles in Vitro by Inhibiting Estrogen Receptor α., PMID:31412668
Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: Functional analysis and tissue distribution., PMID:31351053
Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc., PMID:30150762
Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability., PMID:30084832
Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival., PMID:29682330
Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility., PMID:29554271
miR-210 and GPD1L regulate EDN2 in primary and immortalized human granulosa-lutein cells., PMID:29301980
Endothelin-2 Injures the Blood-Retinal Barrier and Macroglial Müller Cells: Interactions with Angiotensin II, Aldosterone, and NADPH Oxidase., PMID:29248456
Acute stimulation of a smooth muscle constrictor by oestradiol-17β via GPER1 in bovine oviducts., PMID:29134695
Current status of the role of endothelins in regulating ovarian follicular function: A review., PMID:28967452
Granulosa cell endothelin-2 expression is fundamental for ovulatory follicle rupture., PMID:28400616
Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation., PMID:28216513
Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways., PMID:28041965
Biomarkers for Diabetic Retinopathy - Could Endothelin 2 Be Part of the Answer?, PMID:27482904
Core Binding Factor-β Knockdown Alters Ovarian Gene Expression and Function in the Mouse., PMID:27176614
Roles of EDNs in regulating oviductal NO synthesis and smooth muscle motility in cows., PMID:26980806
Altered gene expression profile in ovarian follicle in rats treated with indomethacin and RU486., PMID:25972201
Generation and characterization of an endothelin-2 iCre mouse., PMID:25604013
Endothelin2 Induces Expression of Genes Associated with Reactive Gliosis in Retinal Müller Cells., PMID:25546127
HIF1A-dependent increase in endothelin 2 levels in granulosa cells: role of hypoxia, LH/cAMP, and reactive oxygen species., PMID:25433027
Endothelin as a local regulating factor in the bovine oviduct., PMID:25370848
Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy., PMID:25203536
Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma., PMID:25132557
Endothelin and vascular remodelling in colitis pathogenesis--appendicitis and appendectomy limit colitis by suppressing endothelin pathways., PMID:25085204
Loss of function of endothelin-2 leads to reduced ovulation and CL formation., PMID:24763822
Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer., PMID:24325916
Genetic variance in nitric oxide synthase and endothelin genes among children with and without endothelial dysfunction., PMID:24063765
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis., PMID:24043815
Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea., PMID:24010499
Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells., PMID:23836924
For research use only. Not for human or drug use.
