Catalog No.
YHD41001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn809-His1066
Predicted molecular weight
31.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20701
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance., PMID:40512837
MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases., PMID:40312574
Elevated PD-L1 Expression on Circulating Classical Monocytes Upon Checkpoint Inhibitor Therapy Is Associated With Increased Plasma Interleukin 5 in Patients With Lung Cancer., PMID:40295054
Multifaceted, unique role of CD11c in leukocyte biology., PMID:40103815
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming., PMID:40069143
Phenotypes of porcine blood CD8β T cells and their capacity for IFN gamma production in the context of PRV vaccination., PMID:39988100
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580
Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation., PMID:39867459
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806
Sensing of SARS-CoV-2-infected cells by plasmacytoid dendritic cells is modulated via an interplay between CD54/ICAM-1 and CD11a/LFA-1 αL integrin., PMID:39804090
TOX Does Not Drive Sepsis-Induced T-Cell Exhaustion., PMID:39676393
Differential tumor protein expression at follicular lymphoma diagnosis reveals dysregulation of key molecular pathways associated with histological transformation., PMID:39622932
Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases., PMID:39603636
Integrin β2 regulates titanium particle‑induced inflammation in macrophages: In vitro aseptic loosening model., PMID:39540364
Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality., PMID:39181199
IRG1/ACOD1 promotes neutrophil reverse migration and alleviates local inflammation., PMID:38713770
Runx3 Regulates CD8+ T Cell Local Expansion and CD43 Glycosylation in Mice by H1N1 Influenza A Virus Infection., PMID:38673806
Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB., PMID:38614129
Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11., PMID:38609887
Differentiation marker-negative CD4+ T cells persist after yellow fever virus vaccination and contribute to durable memory., PMID:38559113
1,8-Cineol Attenuates Checkpoint Molecule PDL-1 and Adhesion Molecule CX3CR1 in Circulating Monocytes in Otitis Media Patients., PMID:38541021
Eosinophils exhibit a unique transcriptional signature and increased sensitivity to IL-3-induced activation in response to colorectal cancer cells., PMID:38478700
Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells., PMID:38393325
Anti-Inflammatory Effect of Synaptamide in Ischemic Acute Kidney Injury and the Role of G-Protein-Coupled Receptor 110., PMID:38338779
Integrins in Health and Disease-Suitable Targets for Treatment?, PMID:38334604
LFA-1 nanoclusters integrate TCR stimulation strength to tune T-cell cytotoxic activity., PMID:38195629
Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets., PMID:38172514
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders., PMID:38091952
Clinical manifestations and expression of CD18 to guide the diagnosis of leukocyte adhesion deficiency type 1: Mexico experience., PMID:37937501
CD28/PD1 co-expression: dual impact on CD8+ T cells in peripheral blood and tumor tissue, and its significance in NSCLC patients' survival and ICB response., PMID:37898752
OMIP-099: 31-color spectral flow cytometry panel to investigate the steady-state phenotype of human T cells., PMID:37814476
CD11a regulates hematopoietic stem and progenitor cells., PMID:37781399
Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis., PMID:37752582
Islet beta-cells and intercellular adhesion molecule-1 (ICAM-1): Integrating immune responses that influence autoimmunity and graft rejection., PMID:37619906
Analysis of Novel Immunological Biomarkers Related to Rheumatoid Arthritis Disease Severity., PMID:37569732
Clinical and immunological characteristics of 69 leukocyte adhesion deficiency-I patients., PMID:37492921
Circulating antigen-primed cytotoxic T-cells in patients with renal tumors treated with surgery., PMID:37414595
Tobacco exposure primes the secretion of CCL21 positively associated with tertiary lymphoid structure and response to immunotherapy., PMID:37369391
Jieduquyuziyin prescription enhances CD11a and CD70 DNA methylation of CD4+ T cells via miR-29b-sp1/DNMT1 pathway in MRL/lpr mice., PMID:37343653
Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations., PMID:37310029
Upregulation of CD226 on subsets of T cells and NK cells is associated with upregulated adhesion molecules and cytotoxic factors in patients with tuberculosis., PMID:37244120
Tff3-/- Knock-Out Mice with Altered Lipid Metabolism Exhibit a Lower Level of Inflammation following the Dietary Intake of Sodium Chloride for One Week., PMID:37108475
Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses., PMID:37054891
The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells-Lessons Learned from Different Transgenic Mouse Models., PMID:37047302
Trail Formation Alleviates Excessive Adhesion and Maintains Efficient Neutrophil Migration., PMID:36976830
Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15., PMID:36944397
Allosteric targeting resolves limitations of earlier LFA-1 directed modalities., PMID:36921634
Plasma Leptin Levels, Obstructive Sleep Apnea Syndrome, and Diabetes Are Associated with Obesity-Related Alterations of Peripheral Blood Monocyte Subsets., PMID:36921085
Cutting Edge: Influenza-Induced CD11alo Airway CD103+ Tissue Resident Memory T Cells Exhibit Compromised IFN-γ Production after In Vivo TCR Stimulation., PMID:36912465
Phenotyping and Genotyping of HNA: Prevalence, Risk of Alloimmunization, and HNA Incompatibilities in Indians., PMID:36818775
For research use only. Not for human or drug use.
