Catalog No.
YHD40901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala426-Glu558
Predicted molecular weight
16.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20700
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LMN2, Lamin-B1, LMNB, LMNB1
LMNB1 regulates breast cancer cell senescence and migration through PPAR signaling pathway., PMID:40515805
Autophagic degradation of SQSTM1 enables fibroblast activation to accelerate wound healing., PMID:40400126
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway., PMID:40315640
Phase separation of MRG15 delays cellular senescence., PMID:40312521
Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD., PMID:40304287
An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancer., PMID:40289088
A high throughput, high content screen for non-toxic small molecules that reduce levels of the nuclear lamina protein, Lamin B1., PMID:40025114
The synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML., PMID:40020188
Development of Reliable and High-Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options., PMID:39960283
An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants., PMID:39910058
Mangiferin protects mesenchymal stem cells against DNA damage and cellular aging via SIRT1 activation., PMID:39874993
Role of lamins in cellular physiology and cancer., PMID:39843134
Identification of biomarkers associated with ferroptosis in macrophages infected with Mycobacterium abscessus using bioinformatic tools., PMID:39792889
Impact of Nuclear Peripheral Chromatin Lamin LMNB1 Gene in the Proliferation and Migration of Glioma Cells., PMID:39636549
Increased inflammation in older high-pressure glaucoma mice., PMID:39481321
Construction and validation of a histone-related gene signature for the diagnosis of endometriosis., PMID:39411815
Microarray analysis points to LMNB1 and JUN as potential target genes for predicting metastasis promotion by etoposide in colorectal cancer., PMID:39390002
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma., PMID:39367409
Mechanism of LMNB1 activating GPR84 through JAK-STAT pathway to mediate M2 macrophage polarization in lung cancer., PMID:39357468
Combined treatment with Aronia berry extract and oligomeric proanthocyanidins exhibit a synergistic anticancer efficacy through LMNB1-AKT signaling pathways in colorectal cancer., PMID:39282961
Proteomic analysis of peripheral blood mononuclear cells from OSCC patients reveals potential immune checkpoints to enable personalized treatment., PMID:39177064
Integrative Proteomics-Metabolomics of In Vitro Degeneration of Cardiovascular Cell Lines., PMID:39110328
Unveiling the role of protein kinase A (PKA) activity in bovine oviductal epithelial cells: implications on apoptotic signaling pathways during the estrous cycle., PMID:39105776
PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation., PMID:39103492
Structural Variants at the LMNB1 Locus: Deciphering Pathomechanisms in Autosomal Dominant Adult-Onset Demyelinating Leukodystrophy., PMID:39078102
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer., PMID:38964523
Comparative proteomic analyses to investigate premature browning in high‑oxygen modified atmosphere packaged beef patties., PMID:38876067
SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction., PMID:38870534
Mechanism and role of nuclear laminin B1 in cell senescence and malignant tumors., PMID:38824174
LMNB1/CDKN1A Signaling Regulates the Cell Cycle and Promotes Hepatocellular Carcinoma Progression., PMID:38778606
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways., PMID:38517565
Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity., PMID:38485766
Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease., PMID:38360694
UBC9-mediated SUMOylation of Lamin B1 enhances DNA-damage-induced nuclear DNA leakage and autophagy after spinal cord injury., PMID:38308641
ENPP1 inhibits the transcription activity of the hepatitis B virus pregenomic promoter by upregulating the acetylation of LMNB1., PMID:38265511
Lamin B1: a novel biomarker in adult and pediatric adrenocortical carcinoma., PMID:38224097
Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population., PMID:38166557
Disclosing Potential Therapeutic Targets Associated With Osimertinib Resistance in the Non-small Cell Lung Cancer Cell Line H1975., PMID:38030186
Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles., PMID:37974331
Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids., PMID:37902188
PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions., PMID:37864298
METTL3-mediated N6-methyladenosine modification stimulates mitochondrial damage and ferroptosis of kidney tubular epithelial cells following acute kidney injury by modulating the stabilization of MDM2-p53-LMNB1 axis., PMID:37542992
Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models., PMID:37450245
The mitotic spindle-related seven-gene predicts the prognosis and immune microenvironment of lung adenocarcinoma., PMID:37266661
Unraveling the potential of senescence-related genes in guiding clinical therapy of lung adenocarcinoma patients., PMID:37246190
[Lamin B1 regulates the growth of hepatocellular carcinoma cells by influencing telomerase activity]., PMID:37154326
Lamin B1 overexpression alters chromatin organization and gene expression., PMID:37071033
Intertwined Dysregulation of Ribosomal Proteins and Immune Response Delineates SARS-CoV-2 Vaccination Breakthroughs., PMID:37022180
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway., PMID:37003558
A three-marker signature identifies senescence in human breast cancer exposed to neoadjuvant chemotherapy., PMID:36964435
For research use only. Not for human or drug use.
