Catalog No.
YHD39301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp136-Asn215
Predicted molecular weight
11.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20339
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ras-related protein Rab-5A, RAB5A, RAB5
CTRP7 as a molecular biomarker associating with responsiveness to pulmonary vasodilators: insights from human and animal studies in pulmonary arterial hypertension., PMID:40504501
CMTM7 inhibits TLR4 signaling pathway via promoting Rab5 activation and alleviates acute liver injury., PMID:40490565
Hyperactivation of RAB5 disrupts the endosomal Rab cascade leading to endolysosomal dysregulation in Down syndrome: A necessary role for increased APP gene dose., PMID:40339170
Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome., PMID:40339155
Rab5if is a potential therapeutic target of NSCLC., PMID:40318299
Retroviral foamy virus gag induces parkin-dependent mitophagy., PMID:40317036
The involvement of Rab5 in regulating haematopoiesis in the Chinese mitten crab Eriocheir sinensis., PMID:40268073
APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ., PMID:40266681
Caspase-7 and Vitamin D Receptor Gene as Key Genes of Hypertension Caused by Pyroptosis in Human., PMID:40259750
RAB5 is a host dependency factor for the generation of SARS-CoV-2 replication organelles., PMID:40167317
AMPK Activation Downregulates TXNIP, Rab5, and Rab7 Within Minutes, Thereby Inhibiting the Endocytosis-Mediated Entry of Human Pathogenic Viruses., PMID:40072063
Subversion of the host endocytic pathway by Legionella pneumophila-mediated ubiquitination of Rab5., PMID:40035702
A novel, rapidly progressive ataxia due to a spontaneous Myo5a mutation in mice impairs transport proteins and alters mitochondria., PMID:40022605
Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis., PMID:39994216
Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes., PMID:39976236
Cooperation of R and Rab5 regulates crayfish anti-disease immune response by triggering apoptosis., PMID:39971040
ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a-Mediated Signals in Ageing Skeletal Muscle., PMID:39961359
Coordination between ESCRT function and Rab conversion during endosome maturation., PMID:39910226
Deltacoronavirus HKU11, HKU13, PDCoV (HKU15) and HKU17 spike pseudoviruses enter avian DF-1 cells via clathrin-mediated endocytosis in a Rab5-, Rab7- and pH-dependent manner., PMID:39825424
S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism., PMID:39779666
Endocytosis of Wnt ligands from surrounding epithelial cells positions microtubule nucleation sites at dendrite branch points., PMID:39761321
The potential role of vesicle transport-related small GTPases rabs in abiotic stress responses., PMID:39729968
Interplay between elevated RAB5B gene expression and insulin resistance among women with PCOS-insights from a case-control study., PMID:39725769
Motor Function of the Two-Component EEA1-Rab5 Revealed by dcFCCS., PMID:39704939
Discovery of a Small Molecule with an Inhibitory Role for RAB11., PMID:39684933
Microtubule-Rab5 mutual-influential system screening based on gene-regulatory networks map in Rab5 RNAi eye-degeneration model., PMID:39631617
A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance., PMID:39630893
Movement of the endoplasmic reticulum is driven by multiple classes of vesicles marked by Rab-GTPases., PMID:39630612
Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation., PMID:39576689
GNG5 is a novel regulator of Aβ42 production in Alzheimer's disease., PMID:39528445
PTP1B Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5-PDGFRβ-Mediated Endocytosis Disruption and Apoptosis., PMID:39517122
Endocytosis restricts dendrite branching via removing ectopically localized branching ligands., PMID:39511227
Endosomal Trafficking Bypassed by the RAB5B-CD109 Interplay Promotes Axonogenesis in KRAS-Mutant Pancreatic Cancer., PMID:39488792
Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development., PMID:39466792
Effect of CFTR Modulators on Oxidative Stress and Autophagy in Non-CFTR-Expressing Cells., PMID:39408688
Changes in early endosomes in rat hippocampal CA1 neurons after transient global cerebral ischaemia., PMID:39329500
Integrin α6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151., PMID:39329462
Silencing GDI2 inhibits proliferation, migration and invasion of colorectal cancer through activation of p53 signaling pathway., PMID:39323841
Unraveling molecular and clinical aspects of ALKBH5 as dual role in colorectal cancer., PMID:39321327
Downregulation of the m6A reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members., PMID:39303913
Toxoplasma FER1 is a versatile and dynamic mediator of differential microneme trafficking and microneme exocytosis., PMID:39294204
The Molecular Mechanism by which LINC00461 Regulates Carfilzomib Resistance in Multiple Myeloma., PMID:39231730
Absence of ATG9A and synaptophysin demixing on Rab5 mutation-induced giant endosomes., PMID:39223639
CD2AP is Co-Expressed with Tropomyosin-Related Kinase A and Ras-Related Protein Rab-5A in Cholinergic Neurons of the Murine Basal Forebrain., PMID:39211110
ELD607 specifically traffics Orai1 to the lysosome leading to inhibition of store operated calcium entry., PMID:39191091
CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A., PMID:39048814
The modulation of the hexosamine biosynthetic pathway impacts the localization of CD36 in macrophages., PMID:39041003
A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes., PMID:39024394
Requirement of Rab5 GTPase during heat stress-induced endocytosis in yeast., PMID:39002672
Increasing the Survival of a Neuronal Model of Alzheimer's Disease Using Docosahexaenoic Acid, Restoring Endolysosomal Functioning by Modifying the Interactions between the Membrane Proteins C99 and Rab5., PMID:38999927
For research use only. Not for human or drug use.
